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Prof. Dr. Sandeep Chaudhary
National Institute of Pharmaceutical Education and Research, Raebareli, India
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Academic Career Length
21Years (2006-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications14 March 2019 in Scientific Reports
Journal Article
Dharmendra Kumar YadavSKSurendra Kumar
Surendra Kumar
Eun Ha ChoiSCSandeep Chaudhary
Sandeep ChaudharyMKMi-hyun Kim
Mi-hyun KimLipid peroxidation by reactive oxygen species (ROS) during oxidative stress is non-enzymatic damage that affects the integrity of biological membrane, and alters the fluidity and permeability. We conducted molecular dynamic simulation studies to evaluate the structural properties of the bilayer after lipid peroxidation and to measure the permeability of distinct ROS. The oxidized membrane contains free fatty acid, ceramide, cholesterol, and 5α-hydroperoxycholesterol (5α-CH). The result of unconstrained molecular dynamic simulations revealed that lipid peroxidation causes area-per-lipid of the bilayer to increase and bilayer thickness to decrease. The simulations also revealed that the oxidized group of 5α-CH (-OOH) moves towards the aqueous layer and its backbone tilts causing lateral expansion of the bilayer membrane. These changes are detrimental to structural and functional properties of the membrane. The measured free energy profile for different ROS (H2O2, HO2, HO, and O2) across the peroxidized lipid bilayer showed that the increase in lipid peroxidation resulted in breaching barrier decrease for all species, allowing easy traversal of the membrane. Thus, lipid peroxidation perturbs the membrane barrier and imposes oxidative stress resulting into apoptosis. The collective insights increase the understanding of oxidation stress at the atomic level.
19 March 2018 in Scientific Reports
Journal Article
Dharmendra Kumar YadavSKSurendra Kumar
Surendra KumarSASaloni
Saloni
SMSanjeev Misra
Sanjeev Misra
LYLalit Yadav
Lalit Yadav
MKMi-hyun Kim
Mi-hyun Kim +6
SIRT6 and COX-2 are oncogenes target that promote the expression of proinflammatory and pro-survival proteins through a signaling pathway, which leads to increased survival and proliferation of tumor cells. However, COX-2 also suppresses skin tumorigenesis and their relationship with SIRT6, making it an interesting target for the discovery of drugs with anti-inflammatory and anti-cancer properties. Herein, we studied the interaction of thieno[3,2-c]pyran analogs and RONS species with SIRT6 and COX-2 through the use of molecular docking and molecular dynamic simulations. Molecular docking studies revealed the importance of hydrophobic and hydrophilic amino acid residues for the stability. The molecular dynamics study examined conformational changes in the enzymes caused by the binding of the substrates and how those changes affected the stability of the protein-drug complex. The average RMSD values of the backbone atoms in compounds 6 and 10 were calculated from 1000 ps to 10000 ps and were found to be 0.13 nm for both compounds. Similarly, the radius of gyration values for compounds 6 and 10 were found to be 1.87 ± 0.03 nm and 1.86 ± 0.02 nm, respectively. The work presented here, will be of great help in lead identification and optimization for early drug discovery.
12 January 2020 in Medicinal Research Reviews
Journal Article
Mohit Kumar TiwariSCSandeep Chaudhary
Sandeep Chaudhary2 October 2015 in Organic Letters
Journal Article
SCSandeep Chaudhary
Sandeep ChaudharyVSVashundhra Sharma
Vashundhra Sharma
PJPradeep K. Jaiswal
Pradeep K. Jaiswal
AGAnil N. Gaikwad
Anil N. Gaikwad
SSSudhir K. Sinha
Sudhir K. SinhaVCVinita Chaturvedi
Vinita Chaturvedi +3
21 February 2013 in Chemistry – A European Journal
Journal Article
YKYuji Kawato
Yuji Kawato
SCSandeep Chaudhary
Sandeep ChaudharyNKNaoya Kumagai
Naoya KumagaiMSMasakatsu Shibasaki
Masakatsu Shibasaki15 May 2020 in Industrial & Engineering Chemistry Research
Journal Article
EREkta Roy
Ekta Roy
ANAchala Nagar
Achala Nagar
SCSandeep Chaudhary
Sandeep ChaudharySPSouvik Pal
Souvik PalAbout Me
Dr. Sandeep Chaudhary did his Ph.D in Organic and Medicinal Chemistry from CSIR-Central Drug Research Institute, Lucknow and Jawaharlal Nehru University, New Delhi from 2002-2007 with Prof. Dr. Chandan Singh. He then moved to the USA and worked as Research Staff (Postdoctoral fellow) at The City University of New York, New York, USA from 2008-2010 with Prof. Wayne W. Harding [Associate Professor, CUNY - Hunter College]. After that, he worked as "JSPS PostDoctoral fellow" at the Institute of Microbial Chemistry, Microbial Chemistry Research Foundation, Tokyo, Japan from 2010-2012 with Prof. Dr. Masakatsu Shibasaki.
Dr. Sandeep Chaudhary is currently serving as a Dean, NIPER-Raebareli since Feb. 2022. He is also currently working as HoD and Associate Professor in the Department of Medicinal Chemistry, NIPER-R, Lucknow since June, 2021. Earlier, he worked as an Assistant Professor, Department of Chemistry, MNIT Jaipur, from Oct. 2012 to June 2021. He has 10 years of total teaching experience and 15 years of total research experience overall.
Profile Summary: Completed projects: 13; Ongoing project: 1; Projects as Host Mentor: 4 (Completed); Organized 1 International Conference and 2 CDP; 75 International Publications and 2 Patents; 68 Int. Conference Proceedings; 10 Workshops; 56 Invited lectures/Plenary/keynote lectures; Ph.D Supervised: 6 (Completed) and 4 (Ongoing); Postdocs Supervised: 4; M.Sc/M.S. (Pharma) Dissertation: 30 (Completed) and 11 (Ongoing)