Josef Havel

Prof. Josef Havel


Research Focus & Metrics

Academic Career Length

45Years (1982-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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31 July 2013 in Journal of Applied Biomedicine
Verified
Journal Article
Closed access
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FAFilippo Amato
Filippo Amato
ALAlberto López
Alberto López
Eladia M Peña-MéndezEladia M Peña-Méndez
Eladia M Peña-Méndez
PVPetr Vanhara
Petr Vanhara
AHAleš Hampl
Aleš Hampl
JHJosef Havel
Josef Havel
An extensive amount of information is currently available to clinical specialists, ranging from details ofclinical symptoms to various types of biochemical data and outputs of imaging devices. Each type of dataprovides information that must be evaluated and assigned to a particular pathology during the diagnosticprocess. To streamline the diagnostic process in daily routine and avoid misdiagnosis, artificial intelligencemethods (especially computer aided diagnosis and artificial neural networks) can be employed. Theseadaptive learning algorithms can handle diverse types of medical data and integrate them into categorizedoutputs. In this paper, we briefly review and discuss the philosophy, capabilities, and limitations of artificialneural networks in medical diagnosis through selected examples

31 July 2008 in Journal of Applied Biomedicine
Verified
Journal Article
Open access
PDF file
NPNagender Reddy Panyala
Nagender Reddy Panyala
Eladia M Peña-MéndezEladia M Peña-Méndez
Eladia M Peña-Méndez
JHJosef Havel
Josef Havel
Nanotechnology is a rapidly growing science of producing and utilizing nano-sized particles that measure in nanometers. These nanomaterials are already having an impact on health care. Now-a-days we are using nanoproducts in various fields. Of...

31 July 2009 in Journal of Applied Biomedicine
Verified
Journal Article
Open access
PDF file
NPNagender Reddy Panyala
Nagender Reddy Panyala
Eladia M Peña-MéndezEladia M Peña-Méndez
Eladia M Peña-Méndez
JHJosef Havel
Josef Havel
Nano-technology has entered the field of medicine in recent decades and many of the nanomaterials developed have already had a high impact on health care. Among nanomaterials, gold nanoparticles (GNPs) and gold quantum dots (QDs) are receiving...

27 August 2009 in Rapid Communications in Mass Spectrometry
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Journal Article
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KSKateřina Sládková
Kateřina Sládková
JHJan Houška
Jan Houška
JHJosef Havel
Josef Havel

31 July 2010 in Journal of Applied Biomedicine
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Journal Article
Open access
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SCSadiqali Cheruthazhekatt
Sadiqali Cheruthazhekatt
MČMirko Černák
Mirko Černák
PSPavel Slavíček
Pavel Slavíček
JHJosef Havel
Josef Havel
The applications of gas plasma and plasma modified materials in the emerging fields of medicine such as dentistry, drug delivery, and tissue engineering are reviewed. Plasma sterilization of both living and non-living objects is safe, fast and...

22 December 2021 in Molecules
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Journal Article
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SMSebastiano Masuri
Sebastiano Masuri
PVPetr Vanhara
Petr Vanhara
MCMaria Grazia Cabiddu
Maria Grazia Cabiddu
LMLukáš Moráň
Lukáš Moráň
JHJosef Havel
Josef Havel
TPTiziana Pivetta
Tiziana Pivetta
Copper is an endogenous metal ion that has been studied to prepare a new antitumoral agent with less side-effects. Copper is involved as a cofactor in several enzymes, in ROS production, in the promotion of tumor progression, metastasis, and angiogenesis, and has been found at high levels in serum and tissues of several types of human cancers. Under these circumstances, two strategies are commonly followed in the development of novel anticancer Copper-based drugs: the sequestration of free Copper ions and the synthesis of Copper complexes that trigger cell death. The latter strategy has been followed in the last 40 years and many reviews have covered the anticancer properties of a broad spectrum of Copper complexes, showing that the activity of these compounds is often multi factored. In this work, we would like to focus on the anticancer properties of mixed Cu(II) complexes bearing substituted or unsubstituted 1,10-phenanthroline based ligands and different classes of inorganic and organic auxiliary ligands. For each metal complex, information regarding the tested cell lines and the mechanistic studies will be reported and discussed. The exerted action mechanisms were presented according to the auxiliary ligand/s, the metallic centers, and the increasing complexity of the compound structures.