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A full chain simulation of the acoustic hadrontherapy monitoring for brain tumours is presented in this work. For the study, a proton beam of 100 MeV is considered. In the first stage, Geant4 is used to simulate the energy deposition and to study the behaviour of the Bragg peak. The energy deposition in the medium produces local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal has been subsequently obtained by solving the thermoacoustic equation. The acoustic propagation has been simulated by FEM methods in the brain and the skull, where a set of piezoelectric sensors are placed. Last, the final received signals in the sensors have been processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadrontherapy.
Jorge Otero; Ivan Felis; Alicia Herrero; José Antonio Diaz Merchan; Miguel Ardid. Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment. Sensors 2020, 20, 2987 .
AMA StyleJorge Otero, Ivan Felis, Alicia Herrero, José Antonio Diaz Merchan, Miguel Ardid. Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment. Sensors. 2020; 20 (10):2987.
Chicago/Turabian StyleJorge Otero; Ivan Felis; Alicia Herrero; José Antonio Diaz Merchan; Miguel Ardid. 2020. "Bragg Peak Localization with Piezoelectric Sensors for Proton Therapy Treatment." Sensors 20, no. 10: 2987.
A full chain simulation of the acoustic hadron therapy monitoring for brain tumors is presented in this work. For the study, a proton beam of 100 MeV was considered. In the first stage, Geant4 was used to simulate the energy deposition and to study the behavior of the Bragg peak. The energy deposition in the medium produced local heating that can be considered instantaneous with respect to the hydrodynamic time scale producing a sound pressure wave. The resulting thermoacoustic signal was subsequently obtained by solving the thermoacoustic equation. The acoustic propagation was simulated by the Finite Element Method (FEM) in the brain and the skull, where a set of piezoelectric sensors were placed. Lastly, the final received signals in the sensors were processed in order to reconstruct the position of the thermal source and, thus, to determine the feasibility and accuracy of acoustic beam monitoring in hadron therapy.
Jorge Otero; Ivan Felis; Miguel Ardid; Alicia Herrero; José A. Merchán. Acoustic Bragg Peak Localization in Proton Therapy Treatment: Simulation Studies. Proceedings 2019, 42, 71 .
AMA StyleJorge Otero, Ivan Felis, Miguel Ardid, Alicia Herrero, José A. Merchán. Acoustic Bragg Peak Localization in Proton Therapy Treatment: Simulation Studies. Proceedings. 2019; 42 (1):71.
Chicago/Turabian StyleJorge Otero; Ivan Felis; Miguel Ardid; Alicia Herrero; José A. Merchán. 2019. "Acoustic Bragg Peak Localization in Proton Therapy Treatment: Simulation Studies." Proceedings 42, no. 1: 71.
We developed an experimental set-up by using a continuous emission X-ray (Pantak DXT-3000) and three types of Pb aprons, with thicknesses of 0.25, 0.5, and 0.75mm, coated with Mylar fiber on their surface. Aprons were placed at a distance of 2.5m from the focus. Aluminum filtration was performed at the beam output to reproduce the qualities of narrow beams, N40 (E =33keV), N80 (E =65keV), and N100 (E =83keV), according to the ISO standard 4037 (1-3). Each apron was fixed with 10 thermoluminescent dosimeters (TLDs) over its surface, five dosimeters before and five dosimeters after irradiation with X-rays. Dosimeter readings were noted, and the attenuation coefficients for each effective energy were calculated. To confirm the method of effective energy of ISO-4037 and evaluate the effectiveness of aprons according to the energy range required for different medical practices, a Monte Carlo simulation using GEANT4 code was performed. Thus, the fluence and the absorbed dose in each of the dosimeters were determined, and then the coefficients of linear attenuation were calculated and compared with the experimental data and with those reported by the National Institute of Standards and Technology. Results were consistent between theoretical calculations and experimental measures. This work will serve to make assessments for other personalized radiation protectors made of Pb.
Hernan Olaya Davila; José Antonio Diaz Merchan; Hector Rene Vega-Carrillo; S.A. Martínez Ovalle. Assessment of the effectiveness of attenuation of Pb aprons by using TLD dosimetry and Monte Carlo calculations. Applied Radiation and Isotopes 2018, 138, 56 -59.
AMA StyleHernan Olaya Davila, José Antonio Diaz Merchan, Hector Rene Vega-Carrillo, S.A. Martínez Ovalle. Assessment of the effectiveness of attenuation of Pb aprons by using TLD dosimetry and Monte Carlo calculations. Applied Radiation and Isotopes. 2018; 138 ():56-59.
Chicago/Turabian StyleHernan Olaya Davila; José Antonio Diaz Merchan; Hector Rene Vega-Carrillo; S.A. Martínez Ovalle. 2018. "Assessment of the effectiveness of attenuation of Pb aprons by using TLD dosimetry and Monte Carlo calculations." Applied Radiation and Isotopes 138, no. : 56-59.
We simulated the neuronal electrical activity using the Hodgkin-Huxleymodel (HH) and a superconductor circuit, containing Josephson junctions. These HH model make possible simulate the main neuronal dynamics characteristics such as action potentials, firing thres hold and refractory period.The purpose of the manuscript is show a method to syncronize a RCL-shunted Josephson junction to a neuronal dynamics represented by the HH model. Thus the RCLSJ circuit is able to mimics the behavior of the HH neuron. We controlated the RCLSJ circuit, using and improved adaptative track scheme, that with the improved Lyapunov functions and thetwo controllable gain coefficients allowing synchronization of two neuronal models. Results will provide the path to follow forward the understanding neuronal networks synchronization about, generating the intrinsic brain behavior.
Jose A. Díaz M.; Oscar Téquita; Fernando Naranjo; Universidad Pedagógica Y Tecnológica De Colombia; Oscar Fabian Tequita Vargas. Neuronal Synchronization of Electrical Activity, Using the Hodgkin-Huxley Model and RCLSJ Circuit. Ingeniería y Ciencia 2016, 12, 93 -106.
AMA StyleJose A. Díaz M., Oscar Téquita, Fernando Naranjo, Universidad Pedagógica Y Tecnológica De Colombia, Oscar Fabian Tequita Vargas. Neuronal Synchronization of Electrical Activity, Using the Hodgkin-Huxley Model and RCLSJ Circuit. Ingeniería y Ciencia. 2016; 12 (23):93-106.
Chicago/Turabian StyleJose A. Díaz M.; Oscar Téquita; Fernando Naranjo; Universidad Pedagógica Y Tecnológica De Colombia; Oscar Fabian Tequita Vargas. 2016. "Neuronal Synchronization of Electrical Activity, Using the Hodgkin-Huxley Model and RCLSJ Circuit." Ingeniería y Ciencia 12, no. 23: 93-106.