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Dr. Magali Garcia
Laboratoire Inflammation, Tissus Epithéliaux et Cytokines, LITEC EA 4331, Université de Poitiers, Poitiers, France

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0 antimicrobial peptides
0 emerging viruses
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inflammatory response
antimicrobial peptides

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Journal article
Published: 24 July 2021 in Pharmaceuticals
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Hg-CATH and Pb-CATH4 are cathelicidins from Heterocephalus glaber and Python bivittatus that have been previously identified as potent antibacterial peptides. However, their antiviral properties were not previously investigated. In this study, their activity against the herpes simplex virus (HSV)-1 was evaluated during primary human keratinocyte infection. Both of them significantly reduced HSV-1 DNA replication and production of infectious viral particles in keratinocytes at noncytotoxic concentrations, with the stronger activity of Pb-CATH4. These peptides did not show direct virucidal activity and did not exhibit significant immunomodulatory properties, except for Pb-CATH4, which exerted a moderate proinflammatory action. All in all, our results suggest that Hg-CATH and Pb-CATH4 could be potent candidates for the development of new therapies against HSV-1.

ACS Style

Alexia Damour; Magali Garcia; Hye-Sun Cho; Andy Larivière; Nicolas Lévêque; Chankyu Park; Charles Bodet. Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1. Pharmaceuticals 2021, 14, 715 .

AMA Style

Alexia Damour, Magali Garcia, Hye-Sun Cho, Andy Larivière, Nicolas Lévêque, Chankyu Park, Charles Bodet. Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1. Pharmaceuticals. 2021; 14 (8):715.

Chicago/Turabian Style

Alexia Damour; Magali Garcia; Hye-Sun Cho; Andy Larivière; Nicolas Lévêque; Chankyu Park; Charles Bodet. 2021. "Characterisation of Antiviral Activity of Cathelicidins from Naked Mole Rat and Python bivittatus on Human Herpes Simplex Virus 1." Pharmaceuticals 14, no. 8: 715.

Short communication
Published: 15 June 2021 in Current Research in Translational Medicine
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Herpetic encephalitis results from central nervous system invasion by herpes simplex virus. We report the case of a man who developed a cerebral abscess fifteen months after initial Herpetic encephalitis. Retrospectively, antiviral should not have been associated with antibiotics during abscess episode, as transcriptomic analysis reported no viral reactivation.

ACS Style

Mélanie Catroux; Magali Garcia; Nicolas Lévêque; Philippe Page; Gwenael Le Moal; David Boutolleau; France Roblot; Sonia Burrel. Post-herpetic encephalitis cerebral abscess: Viral reactivation or latency site within central nervous system? Current Research in Translational Medicine 2021, 69, 103297 .

AMA Style

Mélanie Catroux, Magali Garcia, Nicolas Lévêque, Philippe Page, Gwenael Le Moal, David Boutolleau, France Roblot, Sonia Burrel. Post-herpetic encephalitis cerebral abscess: Viral reactivation or latency site within central nervous system? Current Research in Translational Medicine. 2021; 69 (3):103297.

Chicago/Turabian Style

Mélanie Catroux; Magali Garcia; Nicolas Lévêque; Philippe Page; Gwenael Le Moal; David Boutolleau; France Roblot; Sonia Burrel. 2021. "Post-herpetic encephalitis cerebral abscess: Viral reactivation or latency site within central nervous system?" Current Research in Translational Medicine 69, no. 3: 103297.

Review
Published: 30 March 2021 in Viruses
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The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of translation and cell death. In addition to these physiological functions, recent studies have highlighted the role of PARPs in host defenses against viruses, either by direct antiviral activity, targeting certain steps of virus replication cycle, or indirect antiviral activity, via modulation of the innate immune response. This review focuses on the antiviral activity of PARPs, as well as strategies developed by viruses to escape their action.

ACS Style

Mathilde Malgras; Magali Garcia; Clément Jousselin; Charles Bodet; Nicolas Lévêque. The Antiviral Activities of Poly-ADP-Ribose Polymerases. Viruses 2021, 13, 582 .

AMA Style

Mathilde Malgras, Magali Garcia, Clément Jousselin, Charles Bodet, Nicolas Lévêque. The Antiviral Activities of Poly-ADP-Ribose Polymerases. Viruses. 2021; 13 (4):582.

Chicago/Turabian Style

Mathilde Malgras; Magali Garcia; Clément Jousselin; Charles Bodet; Nicolas Lévêque. 2021. "The Antiviral Activities of Poly-ADP-Ribose Polymerases." Viruses 13, no. 4: 582.

Journal article
Published: 31 August 2020 in Journal of Clinical Medicine
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This study aims to determine the gastric distribution, density, and diversity of Helicobacter pylori infection. Subtotal resection of the stomachs of three H. pylori-infected and asymptomatic obese patients were collected after a sleeve gastrectomy. Distribution and density of H. pylori were determined using culture and RT-PCR on multiple gastric sites (88, 176, and 101 biopsies per patient). Diversity of H. pylori strains was studied using antibiotic susceptibility testing, random amplified polymorphism DNA (RAPD) typing and cagA gene detection on single-colony isolates (44, 96, and 49 isolates per patient). H. pylori was detected in nearly all analyzed sites (354/365 biopsies, 97%). Antral density was higher in one patient only. The three stomachs were almost exclusively infected by an antibiotic-susceptible strain. One clarithromycin-resistant isolate in one biopsy was detected in two stomachs (1/44 and 1/49 isolates), while in the third one, eight (8/96 isolates) metronidazole-resistant isolates were detected. DNA typing showed infection with cagA-negative strains for one patient, cagA-positive strains for a second patient and the third patient was infected with two different strains of distinct cagA genotypes. Infection with H. pylori is shown to spread to the whole surface of the stomach, but a possibility of minor sub-population of antibiotic-resistant clones, undetectable in routine practice.

ACS Style

Maxime Pichon; Cong Tri Tran; Gaëtan Motillon; Charlotte Debiais; Sylvain Gautier; Marie Aballea; Julie Cremniter; Philippe Vasseur; David Tougeron; Magali Garcia; Martine Garnier; Charles Bodet; Jean Pierre Faure; Christophe Burucoa. Where to Biopsy to Detect Helicobacter pylori and How Many Biopsies Are Needed to Detect Antibiotic Resistance in a Human Stomach. Journal of Clinical Medicine 2020, 9, 2812 .

AMA Style

Maxime Pichon, Cong Tri Tran, Gaëtan Motillon, Charlotte Debiais, Sylvain Gautier, Marie Aballea, Julie Cremniter, Philippe Vasseur, David Tougeron, Magali Garcia, Martine Garnier, Charles Bodet, Jean Pierre Faure, Christophe Burucoa. Where to Biopsy to Detect Helicobacter pylori and How Many Biopsies Are Needed to Detect Antibiotic Resistance in a Human Stomach. Journal of Clinical Medicine. 2020; 9 (9):2812.

Chicago/Turabian Style

Maxime Pichon; Cong Tri Tran; Gaëtan Motillon; Charlotte Debiais; Sylvain Gautier; Marie Aballea; Julie Cremniter; Philippe Vasseur; David Tougeron; Magali Garcia; Martine Garnier; Charles Bodet; Jean Pierre Faure; Christophe Burucoa. 2020. "Where to Biopsy to Detect Helicobacter pylori and How Many Biopsies Are Needed to Detect Antibiotic Resistance in a Human Stomach." Journal of Clinical Medicine 9, no. 9: 2812.

Research paper
Published: 02 August 2018 in Virulence
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Pseudomonas aeruginosa, an opportunistic pathogen involved in skin and lung diseases, possesses numerous virulence factors, including type 2 and 3 secretion systems (T2SS and T3SS) and its flagellum, whose functions remain poorly known during cutaneous infection. Using isogenic mutants deleted from genes encoding each or all of these three virulence factors, we investigated their role in induction of inflammatory response and in tissue invasiveness in human primary keratinocytes and reconstructed epidermis. Our results showed that flagellum, but not T2SS and T3SS, is involved in induction of a large panel of cytokine, chemokine, and antimicrobial peptide (AMP) mRNA in the infected keratinocytes. Chemokine secretion and AMP tissular production were also dependent on the presence of the bacterial flagellum. This pro-inflammatory effect was significantly reduced in keratinocytes infected in presence of anti-toll-like receptor 5 (TLR5) neutralizing antibody. Bacterial invasion of human epidermis and persistence in a mouse model of sub-cutaneous infection were dependent on the P. aeruginosa flagellum. We demonstrated that flagellum constitutes the main virulence factor of P. aeruginosa involved not only in early induction of the epidermis inflammatory response but also in bacterial invasion and cutaneous persistence. P. aeruginosa is mainly sensed by TLR5 during the early innate immune response of human primary keratinocytes.

ACS Style

Magali Garcia; Eric Morello; Julien Garnier; Christine Barrault; Martine Garnier; Christophe Burucoa; Jean-Claude Lecron; Mustapha Si-Tahar; François-Xavier Bernard; Charles Bodet. Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis. Virulence 2018, 9, 1163 -1175.

AMA Style

Magali Garcia, Eric Morello, Julien Garnier, Christine Barrault, Martine Garnier, Christophe Burucoa, Jean-Claude Lecron, Mustapha Si-Tahar, François-Xavier Bernard, Charles Bodet. Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis. Virulence. 2018; 9 (1):1163-1175.

Chicago/Turabian Style

Magali Garcia; Eric Morello; Julien Garnier; Christine Barrault; Martine Garnier; Christophe Burucoa; Jean-Claude Lecron; Mustapha Si-Tahar; François-Xavier Bernard; Charles Bodet. 2018. "Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis." Virulence 9, no. 1: 1163-1175.

Case reports
Published: 16 February 2018 in Journal of Asthma
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ACS Style

Magali Garcia; Gwénaël Le Moal; Jacques Cadranel; France Roblot; Cendrine Godet. Efficacy of nebulized liposomal amphotericin B in the treatment of ABPA in an HIV/HBV co-infected man: Case report and literature review. Journal of Asthma 2018, 56, 84 -86.

AMA Style

Magali Garcia, Gwénaël Le Moal, Jacques Cadranel, France Roblot, Cendrine Godet. Efficacy of nebulized liposomal amphotericin B in the treatment of ABPA in an HIV/HBV co-infected man: Case report and literature review. Journal of Asthma. 2018; 56 (1):84-86.

Chicago/Turabian Style

Magali Garcia; Gwénaël Le Moal; Jacques Cadranel; France Roblot; Cendrine Godet. 2018. "Efficacy of nebulized liposomal amphotericin B in the treatment of ABPA in an HIV/HBV co-infected man: Case report and literature review." Journal of Asthma 56, no. 1: 84-86.

Article
Published: 01 October 2017 in Reviews in Medical Microbiology
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Zika virus (ZIKV) can be transmitted by the mosquito bite, through blood transfusion, organ transplantation and potentially urine or saliva. From its inoculation site, the virus will spread to various organs such as the central nervous system leading to neurological complications, particularly Guillain–Barré syndrome, or the fetus causing microcephaly. During the infection, ZIKV will have to cross multiple barriers according to the route of transmission and the infection site such as the skin, male and female genital mucosa or blood–brain and placental barriers. At these sites, ZIKV will establish an infection that the innate immune response will try to block before systemic spread occurs to the target organs. The aim of this review is to summarize the knowledge on the mechanisms of anti-ZIKV innate immunity, its characteristics at the different barriers encountered and tissues infected during the infection, and on the escape mechanisms developed by the virus to deal with it.

ACS Style

Vincent Lerat; Magali Garcia; Michel Wehbe; Agnès Beby-Defaux; Charles Bodet; Nicolas Lévêque. Innate immunity against Zika virus. Reviews in Medical Microbiology 2017, 28, 167 -174.

AMA Style

Vincent Lerat, Magali Garcia, Michel Wehbe, Agnès Beby-Defaux, Charles Bodet, Nicolas Lévêque. Innate immunity against Zika virus. Reviews in Medical Microbiology. 2017; 28 (4):167-174.

Chicago/Turabian Style

Vincent Lerat; Magali Garcia; Michel Wehbe; Agnès Beby-Defaux; Charles Bodet; Nicolas Lévêque. 2017. "Innate immunity against Zika virus." Reviews in Medical Microbiology 28, no. 4: 167-174.

Journal article
Published: 01 June 2017 in European Cytokine Network
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ACS Style

Magali Garcia; Michel Wehbe; Nicolas Lévêque; Charles Bodet. Skin innate immune response to flaviviral infection. European Cytokine Network 2017, 28, 41 -51.

AMA Style

Magali Garcia, Michel Wehbe, Nicolas Lévêque, Charles Bodet. Skin innate immune response to flaviviral infection. European Cytokine Network. 2017; 28 (2):41-51.

Chicago/Turabian Style

Magali Garcia; Michel Wehbe; Nicolas Lévêque; Charles Bodet. 2017. "Skin innate immune response to flaviviral infection." European Cytokine Network 28, no. 2: 41-51.

Journal article
Published: 01 May 2017 in Journal of Ethnopharmacology
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Leaves of Crateva adansonii DC (Capparidaceae), a small bush found in Togo, are widely used in traditional medicine to cure infectious abscesses. Traditional healers of Lomé harvest only budding leaves early in the morning, in specific area in order to prepare their drugs.

ACS Style

Kplolali Ahama-Esseh; Charles Bodet; Akossiwa Quashie-Mensah-Attoh; Magali Garcia; Isabelle Théry-Koné; Joelle Dorat; Comlan De Souza; Cécile Enguehard-Gueiffier; Leslie Boudesocque-Delaye. Anti-inflammatory activity of Crateva adansonii DC on keratinocytes infected by Staphylococcus aureus : From traditional practice to scientific approach using HPTLC-densitometry. Journal of Ethnopharmacology 2017, 204, 26 -35.

AMA Style

Kplolali Ahama-Esseh, Charles Bodet, Akossiwa Quashie-Mensah-Attoh, Magali Garcia, Isabelle Théry-Koné, Joelle Dorat, Comlan De Souza, Cécile Enguehard-Gueiffier, Leslie Boudesocque-Delaye. Anti-inflammatory activity of Crateva adansonii DC on keratinocytes infected by Staphylococcus aureus : From traditional practice to scientific approach using HPTLC-densitometry. Journal of Ethnopharmacology. 2017; 204 ():26-35.

Chicago/Turabian Style

Kplolali Ahama-Esseh; Charles Bodet; Akossiwa Quashie-Mensah-Attoh; Magali Garcia; Isabelle Théry-Koné; Joelle Dorat; Comlan De Souza; Cécile Enguehard-Gueiffier; Leslie Boudesocque-Delaye. 2017. "Anti-inflammatory activity of Crateva adansonii DC on keratinocytes infected by Staphylococcus aureus : From traditional practice to scientific approach using HPTLC-densitometry." Journal of Ethnopharmacology 204, no. : 26-35.

Comparative study
Published: 29 January 2017 in Journal of Clinical Virology
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EMAG™ (bioMerieux) is a new nucleic acid extraction platform based on magnetic silica technology, like its predecessor, NucliSENS® easyMAG® (bioMerieux). Using the same reagents and disposables, eMAG™ adds further automation, allowing simultaneous extraction of 48 samples directly from primary tubes, and distribution of nucleic acid extracts on PCR strips or in tubes at the end of the extraction process. To compare the performance of eMAG™ and easyMAG® on various clinical specimens. Respiratory (n = 199), whole blood (n = 50), plasma (n = 25) and urine (n = 25) specimens were extracted in parallel on both platforms. Both qualitative (respiratory virus, cell control, CMV, EBV, HHV6 and BKV detection) and quantitative (respiratory virus and cell control cycle thresolds, and CMV, EBV, HHV6 and BKV viral loads) results were compared. Detection of qualitative targets showed good agreement, ranging from 84.6% for whole blood to 95.9% for respiratory specimens. Correlations between quantitative results were good, with R2 ranging from 0.802 to 0.995. Quantitative results showed average overall differences below 0.10 log10 copies/mL between eMAG™ and easyMAG®. The two platforms showed comparable performance on the types of clinical specimen tested. With higher automation and throughput than easyMAG®, the eMAG™ platform is likely to be advantageous for laboratories performing a large number of molecular analyses.

ACS Style

Magali Garcia; Céline Chessa; Anne Bourgoin; Geneviève Giraudeau; Chloé Plouzeau; Gérard Agius; Nicolas Lévêque; Agnès Beby-Defaux. Comparison of eMAG™ versus NucliSENS® EasyMAG® performance on clinical specimens. Journal of Clinical Virology 2017, 88, 52 -57.

AMA Style

Magali Garcia, Céline Chessa, Anne Bourgoin, Geneviève Giraudeau, Chloé Plouzeau, Gérard Agius, Nicolas Lévêque, Agnès Beby-Defaux. Comparison of eMAG™ versus NucliSENS® EasyMAG® performance on clinical specimens. Journal of Clinical Virology. 2017; 88 ():52-57.

Chicago/Turabian Style

Magali Garcia; Céline Chessa; Anne Bourgoin; Geneviève Giraudeau; Chloé Plouzeau; Gérard Agius; Nicolas Lévêque; Agnès Beby-Defaux. 2017. "Comparison of eMAG™ versus NucliSENS® EasyMAG® performance on clinical specimens." Journal of Clinical Virology 88, no. : 52-57.

Research article
Published: 05 December 2016 in Innate Immunity
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Inflammatory signaling pathways induced by Helicobacter pylori remain unclear, having been studied mostly on cell-line models derived from gastric adenocarcinoma with potentially altered signaling pathways and nonfunctional receptors. Here, H. pylori-induced signaling pathways were investigated in primary human gastric epithelial cells. Inflammatory response was analyzed on chemokine mRNA expression and production after infection of gastric epithelial cells by H. pylori strains, B128 and B128Δ cagM, a cag type IV secretion system defective strain. Signaling pathway involvement was investigated using inhibitors of epidermal growth factor receptor (EGFR), MAPK, JAK and blocking Abs against TLR2 and TLR4. Inhibitors of EGFR, MAPK and JAK significantly reduced the chemokine mRNA expression and production induced by both H. pylori strains at 3 h and 24 h post-infection. JNK inhibitor reduced chemokine production at 24 h post-infection. Blocking Abs against TLR2 but not TLR4 showed significant reduction of chemokine secretion. Using primary culture of human gastric epithelial cells, our data suggest that H. pylori can be recognized by TLR2, leading to chemokine induction, and that EGFR, MAPK and the JAK/STAT signaling pathways play a key role in the H. pylori-induced CXCL1, CXCL5 and CXCL8 response in a cag pathogenicity island-independent manner.

ACS Style

Cong Tri Tran; Magali Garcia; Martine Garnier; Christophe Burucoa; Charles Bodet. Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells. Innate Immunity 2016, 23, 165 -174.

AMA Style

Cong Tri Tran, Magali Garcia, Martine Garnier, Christophe Burucoa, Charles Bodet. Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells. Innate Immunity. 2016; 23 (2):165-174.

Chicago/Turabian Style

Cong Tri Tran; Magali Garcia; Martine Garnier; Christophe Burucoa; Charles Bodet. 2016. "Inflammatory signaling pathways induced by Helicobacter pylori in primary human gastric epithelial cells." Innate Immunity 23, no. 2: 165-174.

Journal article
Published: 01 December 2016 in Annales de Dermatologie et de Vénéréologie
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ACS Style

Magali Garcia; Martine Garnier; Julien Garnier; Christine Barrault; Eric Morello; Mustapha Di-Tahar; Jean Claude Lecron; François Xavier Bernard; Charles Bodet. Rôle majeur du flagelle de Pseudomonas aeruginosa dans l’invasion et l’induction de l’inflammation cutanée. Annales de Dermatologie et de Vénéréologie 2016, 143, S425 -S426.

AMA Style

Magali Garcia, Martine Garnier, Julien Garnier, Christine Barrault, Eric Morello, Mustapha Di-Tahar, Jean Claude Lecron, François Xavier Bernard, Charles Bodet. Rôle majeur du flagelle de Pseudomonas aeruginosa dans l’invasion et l’induction de l’inflammation cutanée. Annales de Dermatologie et de Vénéréologie. 2016; 143 (12):S425-S426.

Chicago/Turabian Style

Magali Garcia; Martine Garnier; Julien Garnier; Christine Barrault; Eric Morello; Mustapha Di-Tahar; Jean Claude Lecron; François Xavier Bernard; Charles Bodet. 2016. "Rôle majeur du flagelle de Pseudomonas aeruginosa dans l’invasion et l’induction de l’inflammation cutanée." Annales de Dermatologie et de Vénéréologie 143, no. 12: S425-S426.

Journal article
Published: 01 December 2016 in Anaerobe
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Up until now, Bacteroides faecis, a Gram-negative, anaerobic, non-motile, nonsporeforming rod has been principally described as a commensal microbe isolated from the feces of healthy adults. We report the first case of human Bacteroides faecis sepsis after removal of suspected post-colonic ischemia colonized epicardic electrodes. Electrodes and blood cultures both grew Gram-negative anaerobic rods but usual phenotypic methods and 16S rARN gene sequencing failed to ensure its species identification. B. faecis was finally identified using hsp60 gene sequencing. Because this species is not well-known and is difficult to identify, it may have been overlooked or misidentified in previous studies.

ACS Style

M. Garcia; P. Bouvet; F. Petitpas; C. Jayle; C. Legeay; J. Sautereau; A. Michaud; C. Burucoa; C. Plouzeau. First case report of a human sepsis involving a recently identified anaerobic agent: Bacteroides faecis. Anaerobe 2016, 42, 74 -77.

AMA Style

M. Garcia, P. Bouvet, F. Petitpas, C. Jayle, C. Legeay, J. Sautereau, A. Michaud, C. Burucoa, C. Plouzeau. First case report of a human sepsis involving a recently identified anaerobic agent: Bacteroides faecis. Anaerobe. 2016; 42 ():74-77.

Chicago/Turabian Style

M. Garcia; P. Bouvet; F. Petitpas; C. Jayle; C. Legeay; J. Sautereau; A. Michaud; C. Burucoa; C. Plouzeau. 2016. "First case report of a human sepsis involving a recently identified anaerobic agent: Bacteroides faecis." Anaerobe 42, no. : 74-77.

Short communication
Published: 09 November 2016 in Current Research in Translational Medicine
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Selenium deficiency adversely affects the clinical outcome of measles in the tropics. In developed countries, serum selenium level has never been investigated during acute measles. The aim of this study was to determine serum selenium concentrations in French patients with acute measles and to seek correlations with clinical and virological findings. We studied serum selenium concentrations in 94 French patients with acute measles and in 99 healthy controls matched for age and sex. The mean of selenium concentration was significantly lower in the patients than in the controls (46.4 ± 14.1 μg/L versus 86.5 ± 13.9 μg/L, P < 0.0001). In the patients, selenium concentrations were not associated with age, sex, vaccination status, clinical signs or specific antibody responses. Selenium levels did not differ significantly between patients with uncomplicated measles (45.8 ± 14.2 μg/L) and patients with complications (52.7 ± 13.2 μg/L) (P = 0.15). Acute measles is associated with significant reduction of selenium level that did not seem to negatively affect the course of the disease suggesting compensating mechanisms in patients from developed countries against the disease.

ACS Style

Magali Garcia; A. Pineau; O. Guillard; S. Ragot; N. Lévêque; G. Agius. Low serum selenium concentrations in French patients with measles. Current Research in Translational Medicine 2016, 65, 89 -91.

AMA Style

Magali Garcia, A. Pineau, O. Guillard, S. Ragot, N. Lévêque, G. Agius. Low serum selenium concentrations in French patients with measles. Current Research in Translational Medicine. 2016; 65 (2):89-91.

Chicago/Turabian Style

Magali Garcia; A. Pineau; O. Guillard; S. Ragot; N. Lévêque; G. Agius. 2016. "Low serum selenium concentrations in French patients with measles." Current Research in Translational Medicine 65, no. 2: 89-91.

Short communication
Published: 11 October 2016 in Annales de Dermatologie et de Vénéréologie
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Les leishmanioses viscérales n’ont habituellement pas d’expression cutanée. Nous rapportons l’observation d’une patiente vivant avec le VIH qui a développé deux manifestations cutanées exceptionnelles au cours d’une leishmaniose viscérale. Une femme de 48 ans consultait initialement pour un purpura infiltré des quatre membres. La biopsie cutanée montrait une vascularite leucocytoclasique associée à la présence de corps de Leishman. Le bilan paraclinique objectivait une atteinte médullaire, splénique, gastrique et colique permettant d’établir le diagnostic de leishmaniose viscérale. Malgré un traitement prolongé, elle présentait deux ans plus tard un exanthème maculopapuleux, avec toujours la présence de corps de Leishman à l’examen histologique. Les deux éruptions cutanées observées successivement en association à la leishmaniose viscérale de la patiente font l’originalité de cette observation. Leurs mécanismes restent hypothétiques. La vascularite leucocytoclasique initiale pourrait être secondaire, soit à une hypergammaglobulinémie polyclonale, soit à des dépôts d’IgA, soit encore à une atteinte mécanique des vaisseaux par le parasite lui-même. L’exanthème maculopapuleux survenu à distance peut faire discuter une leishmaniose post-Kala-Azar consécutive à une dissémination hématogène du sujet anergique, ou bien un syndrome de restauration immunitaire. Visceral leishmaniasis is not normally expressed in skin. Herein, we describe the case of an HIV-positive patient who developed two unusual skin manifestations during an episode of visceral leishmaniasis. A 48-year-old female patient consulted initially for infiltrated purpura of all four limbs. Skin biopsy revealed leukocytoclastic vasculitis with Leishman-Donovan bodies. Laboratory tests showed medullary, splenic, gastric and colic involvement, suggesting systemic disease, and enabling visceral leishmaniasis to be diagnosed. Two years later, despite prolonged treatment, the patient presented maculopapular exanthema, and histology revealed persistent Leishman-Donovan bodies. We report herein an association of two rare skin manifestations in an HIV-positive patient with visceral leishmaniasis: infiltrated purpura and maculopapular exanthema. However, the underlying mechanisms remain hypothetical. The initial leukocytoclastic exanthema could be secondary to either polyclonal hypergammaglobulinaemia or to IgA deposits, or possibly to mechanical impairment of blood vessels by the actual parasite. The maculopapular exanthema occurring later raised the possibility of post-Kala-Azar leishmaniasis due to blood-borne dissemination in an anergic subject or perhaps even immune reconstitution inflammatory syndrome.

ACS Style

C. Cossart; G. Le Moal; M. Garcia; E. Frouin; E. Hainaut-Wierzbicka; France Roblot. Manifestations cutanées inhabituelles au cours d’une leishmaniose viscérale associée au VIH. Annales de Dermatologie et de Vénéréologie 2016, 143, 841 -845.

AMA Style

C. Cossart, G. Le Moal, M. Garcia, E. Frouin, E. Hainaut-Wierzbicka, France Roblot. Manifestations cutanées inhabituelles au cours d’une leishmaniose viscérale associée au VIH. Annales de Dermatologie et de Vénéréologie. 2016; 143 (12):841-845.

Chicago/Turabian Style

C. Cossart; G. Le Moal; M. Garcia; E. Frouin; E. Hainaut-Wierzbicka; France Roblot. 2016. "Manifestations cutanées inhabituelles au cours d’une leishmaniose viscérale associée au VIH." Annales de Dermatologie et de Vénéréologie 143, no. 12: 841-845.

Journal article
Published: 04 September 2016 in Helicobacter
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Human gastric mucosa shows continuous self-renewal via differentiation from stem cells that remain poorly characterized. We describe an original protocol for culture of gastric stem/progenitor cells from adult human stomach. The molecular characteristics of cells were studied using TaqMan low-density array and qRT-PCR analyses using the well-characterized H1 and H9 embryonic stem cells as reference. Epithelial progenitor cells were challenged with H. pylori to characterize their inflammatory response. Resident gastric stem cells expressed specific molecular markers of embryonic stem cells (SOX2, NANOG, and OCT4), as well as others specific to adult stem cells, particularly LGR5 and CD44. We show that gastric stem cells spontaneously differentiate into epithelial progenitor cells that can be challenged with H. pylori. The epithelial progenitor response to H. pylori showed a cag pathogenicity island-dependent induction of matrix metalloproteinases 1 and 3, chemokine (CXCL1, CXCL5, CXCL8, CCL20) and interleukine 33 expression. This study opens new outlooks for investigation of gastric stem cell biology and pathobiology as well as host–H. pylori interactions.

ACS Style

Magali Garcia; Jean Claude Chomel; Pascale Mustapha; Cong Tri Tran; Martine Garnier; Isabelle Paris; Nathalie Quellard; Julie Godet; Julie Cremniter; Annelise Bennaceur Griscelli; Jean-Claude Lecron; Ali Turhan; Christophe Burucoa; Charles Bodet. In vitro culture and phenotypic and molecular characterization of gastric stem cells from human stomach. Helicobacter 2016, 22, e12351 .

AMA Style

Magali Garcia, Jean Claude Chomel, Pascale Mustapha, Cong Tri Tran, Martine Garnier, Isabelle Paris, Nathalie Quellard, Julie Godet, Julie Cremniter, Annelise Bennaceur Griscelli, Jean-Claude Lecron, Ali Turhan, Christophe Burucoa, Charles Bodet. In vitro culture and phenotypic and molecular characterization of gastric stem cells from human stomach. Helicobacter. 2016; 22 (2):e12351.

Chicago/Turabian Style

Magali Garcia; Jean Claude Chomel; Pascale Mustapha; Cong Tri Tran; Martine Garnier; Isabelle Paris; Nathalie Quellard; Julie Godet; Julie Cremniter; Annelise Bennaceur Griscelli; Jean-Claude Lecron; Ali Turhan; Christophe Burucoa; Charles Bodet. 2016. "In vitro culture and phenotypic and molecular characterization of gastric stem cells from human stomach." Helicobacter 22, no. 2: e12351.

Case reports
Published: 01 June 2016 in AIDS
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ACS Style

Magali Garcia; Gwenaël Le Moal; Cendrine Godet; Guillaume Béraud; Carine Chagneau-Derrode; France Roblot. First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome. AIDS 2016, 30, 1487 -1488.

AMA Style

Magali Garcia, Gwenaël Le Moal, Cendrine Godet, Guillaume Béraud, Carine Chagneau-Derrode, France Roblot. First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome. AIDS. 2016; 30 (9):1487-1488.

Chicago/Turabian Style

Magali Garcia; Gwenaël Le Moal; Cendrine Godet; Guillaume Béraud; Carine Chagneau-Derrode; France Roblot. 2016. "First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome." AIDS 30, no. 9: 1487-1488.

Journal article
Published: 01 June 2016 in Médecine et Maladies Infectieuses
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C. Grignon; G. Le Moal; Nicolas Venisse; P. Lazaro; M. Garcia; France Roblot; A. Dupuis. BU-25 - Amoxicilline en perfusion continue : quelle stabilité physicochimique ? Médecine et Maladies Infectieuses 2016, 46, 37 -38.

AMA Style

C. Grignon, G. Le Moal, Nicolas Venisse, P. Lazaro, M. Garcia, France Roblot, A. Dupuis. BU-25 - Amoxicilline en perfusion continue : quelle stabilité physicochimique ? Médecine et Maladies Infectieuses. 2016; 46 (4):37-38.

Chicago/Turabian Style

C. Grignon; G. Le Moal; Nicolas Venisse; P. Lazaro; M. Garcia; France Roblot; A. Dupuis. 2016. "BU-25 - Amoxicilline en perfusion continue : quelle stabilité physicochimique ?" Médecine et Maladies Infectieuses 46, no. 4: 37-38.

Journal article
Published: 07 April 2016 in Transplant Infectious Disease
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Infectious diarrhea is a frequent complication after kidney transplantation (1). Following acute infection, long-term asymptomatic excretion, from several weeks to several months, of enteric pathogens as norovirus has been described in transplant recipients (2, 3). Nevertheless, risk factors of shedding remain still unknown. For this purpose, 56 stool samples from asymptomatic adult kidney transplant recipients were retrospectively tested with broad-spectrum molecular tests (xTAG GPP®, Luminex Molecular Diagnostics, Toronto, Canada) allowing the detection of the most common gastroenteritis-causing bacteria, parasites, and viruses (4).This article is protected by copyright. All rights reserved.

ACS Style

B. Schvartz; M. Garcia; A. Wolak‐Thierry; C. De Champs; Nicolas Leveque. Risk factors of asymptomatic shedding of enteric pathogens in renal transplant recipients. Transplant Infectious Disease 2016, 18, 480 -482.

AMA Style

B. Schvartz, M. Garcia, A. Wolak‐Thierry, C. De Champs, Nicolas Leveque. Risk factors of asymptomatic shedding of enteric pathogens in renal transplant recipients. Transplant Infectious Disease. 2016; 18 (3):480-482.

Chicago/Turabian Style

B. Schvartz; M. Garcia; A. Wolak‐Thierry; C. De Champs; Nicolas Leveque. 2016. "Risk factors of asymptomatic shedding of enteric pathogens in renal transplant recipients." Transplant Infectious Disease 18, no. 3: 480-482.

Journal article
Published: 07 March 2016 in Expert Review of Anti-infective Therapy
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Magali Garcia; Agnès Beby-Defaux; Nicolas Leveque. Respiratory viruses as a cause of sudden death. Expert Review of Anti-infective Therapy 2016, 14, 359 -363.

AMA Style

Magali Garcia, Agnès Beby-Defaux, Nicolas Leveque. Respiratory viruses as a cause of sudden death. Expert Review of Anti-infective Therapy. 2016; 14 (4):359-363.

Chicago/Turabian Style

Magali Garcia; Agnès Beby-Defaux; Nicolas Leveque. 2016. "Respiratory viruses as a cause of sudden death." Expert Review of Anti-infective Therapy 14, no. 4: 359-363.