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Ms. Mihaiela Cornea-Cipcigan
University of Agricultural Sciences and Veterinary Medicine, 3-5 Mănăștur Street, 400372, Cluj-Napoca, Romania

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0 Palynology
0 Plant Breeding
0 pollen
0 Plant biotechnology
0 Plant Abiotic Stress Physiology

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Journal article
Published: 22 July 2021 in Molecules
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Bioactive molecules from the class of polyphenols are secondary metabolites from plants. They are present in honey from nectar and pollen of flowers from where honeybees collect the “raw material” to produce honey. Robinia pseudoacacia and Helianthus annuus are important sources of nectar for production of two monofloral honeys with specific characteristics and important biological activity. A high-performance liquid chromatography–electro spray ionization–mass spectrometry (HPLC–ESI–MS) separation method was used to determine polyphenolic profile from the two types of Romanian unifloral honeys. Robinia and Helianthus honey showed a common flavonoid profile, where pinobanksin (1.61 and 1.94 mg/kg), pinocembrin (0.97 and 1.78 mg/kg) and chrysin (0.96 and 1.08 mg/kg) were identified in both honey types; a characteristic flavonoid profile in which acacetin (1.20 mg/kg), specific only for Robinia honey, was shown; and quercetin (1.85 mg/kg), luteolin (21.03 mg/kg), kaempferol (0.96 mg/kg) and galangin (1.89 mg/kg), specific for Helianthus honey, were shown. In addition, different phenolic acids were found in Robinia and Helianthus honey, while abscisic acid was found only in Robinia honey. Abscisic acid was correlated with geographical location; the samples collected from the south part of Romania had higher amounts, due to climatic conditions. Acacetin was proposed as a biochemical marker for Romanian Robinia honey and quercetin for Helianthus honey.

ACS Style

Otilia Bobiş; Victoriţa Bonta; Mihaiela Cornea-Cipcigan; Gulzar Nayik; Daniel Dezmirean. Bioactive Molecules for Discriminating Robinia and Helianthus Honey: High-Performance Liquid Chromatography–Electron Spray Ionization–Mass Spectrometry Polyphenolic Profile and Physicochemical Determinations. Molecules 2021, 26, 4433 .

AMA Style

Otilia Bobiş, Victoriţa Bonta, Mihaiela Cornea-Cipcigan, Gulzar Nayik, Daniel Dezmirean. Bioactive Molecules for Discriminating Robinia and Helianthus Honey: High-Performance Liquid Chromatography–Electron Spray Ionization–Mass Spectrometry Polyphenolic Profile and Physicochemical Determinations. Molecules. 2021; 26 (15):4433.

Chicago/Turabian Style

Otilia Bobiş; Victoriţa Bonta; Mihaiela Cornea-Cipcigan; Gulzar Nayik; Daniel Dezmirean. 2021. "Bioactive Molecules for Discriminating Robinia and Helianthus Honey: High-Performance Liquid Chromatography–Electron Spray Ionization–Mass Spectrometry Polyphenolic Profile and Physicochemical Determinations." Molecules 26, no. 15: 4433.

Review
Published: 25 June 2021 in Antioxidants
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Background: vegetative diversity is based on different climate and geographical origins. In terms of beekeeping, herbal diversity is strongly correlated to the production of a wide variety of honey. Therefore, based on the existing plant diversity in each country, multiple honey varieties are produced with different health characteristics. While beekeeping potential and consumption preferences are reflected in products’ variety, this leads to an increase in the region’s economy and extensive export. In the last years, monofloral honey has gained interest from consumers and especially in the medicinal field due to the presence of phytochemicals which are directly linked to health benefits, wound healing, antioxidant, anticancer and anti-inflammatory activities. Scope and approach: this review aims to highlight the physicochemical properties, mineral profiles and antioxidant activities of selected monofloral honeys based on their botanical and geographical origin. Moreover, this review focuses on the intercorrelation between monofloral honey’s antioxidant compounds and in vitro and in vivo activities, focusing on the apoptosis and cell proliferation inhibition in various cell lines, with a final usage of honey as a potential therapeutic product in the fight towards reducing tumor growth. Key findings and conclusions: multiple studies have demonstrated that monofloral honeys have different physicochemical structures and bioactive compounds. Useful chemical markers to distinguish between monofloral honeys were evidenced, such as: 2-methoxybenzoic acid and trimethoxybenzoic acid are distinctive to Manuka honey while 4-methoxyphenylacetic acid is characteristic to Kanuka honey. Furthermore, resveratrol, epigallocatechin and pinostrobin are markers distinct to Sage honey, whereas carvacrol and thymol are found in Ziziphus honey. Due to their polyphenolic profile, monofloral honeys have significant antioxidant activity, as well as antidiabetic, antimicrobial and anticancer activities. It was demonstrated that Pine honey decreased the MDA and TBARS levels in liver, kidney, heart and brain tissues, whereas Malicia honey reduced the low-density lipoprotein level. Consumption of Clover, Acacia and Gelam honeys reduced the weight and adiposity, as well as trygliceride levels. Furthermore, the antiproliferative effect of chrysin, a natural flavone in Acacia honey, was demonstrated in human (A375) and murine (B16-F1) melanoma cell lines, whereas caffeic acid, a phenolic compound found in Kelulut honey, proves to be significant candidate in the chemoprevention of colon cancer. Based on these features, the use of hiney in the medicinal field (apitherapy), and the widespread usage of natural product consumption, is gaining interest by each year.

ACS Style

Rodica Mărgăoan; Erkan Topal; Ralitsa Balkanska; Banu Yücel; Titanilla Oravecz; Mihaiela Cornea-Cipcigan; Dan Vodnar. Monofloral Honeys as a Potential Source of Natural Antioxidants, Minerals and Medicine. Antioxidants 2021, 10, 1023 .

AMA Style

Rodica Mărgăoan, Erkan Topal, Ralitsa Balkanska, Banu Yücel, Titanilla Oravecz, Mihaiela Cornea-Cipcigan, Dan Vodnar. Monofloral Honeys as a Potential Source of Natural Antioxidants, Minerals and Medicine. Antioxidants. 2021; 10 (7):1023.

Chicago/Turabian Style

Rodica Mărgăoan; Erkan Topal; Ralitsa Balkanska; Banu Yücel; Titanilla Oravecz; Mihaiela Cornea-Cipcigan; Dan Vodnar. 2021. "Monofloral Honeys as a Potential Source of Natural Antioxidants, Minerals and Medicine." Antioxidants 10, no. 7: 1023.

Journal article
Published: 15 June 2021 in LWT
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The aim of this study was to determine the botanical origin, phenolics, flavonoids and fatty acids content, antioxidant and antimicrobial properties, of 18 bee collected pollen (BP) samples from Turkey and Romania. Five plant families with predominant pollens (>45%) were found in the Turkish samples, and only three in the Romanian samples. The phenolic content, varied between 16.40 and 41.17 mg GAE/g and the flavonoids content varied between 2.39 and 7.17 mg QE/g. The highest value of DPPH was 2.93 mmol Trolox/g and 9.64 mmol Trolox/g for the TEAC, whereas the IC50 value of α-Amylase inhibition was 8.10 mg/mL. We also verified that the presence of the methanolic extract of BP differentially affected the growth of Gram-positive and Gram-negative bacteria under study, strongly depending on the microorganism and the botanical origin of the BP samples used. The fatty acids contents were closely correlated with the above-mentioned parameters especially with the botanical origin and antibacterial activity. Our findings suggest that BP is a rich source of unsaturated fatty acids and bioactive compounds, which can be considered a value-added product. Furthermore, the differences in Turkish and Romanian BP chemical composition is also shown based on their antimicrobial and α-amylase inhibitory activities.

ACS Style

Rodica Mărgăoan; Aslı Özkök; Şaban Keskin; Nazlı Mayda; Adriana Cristina Urcan; Mihaiela Cornea-Cipcigan. Bee collected pollen as a value-added product rich in bioactive compounds and unsaturated fatty acids: A comparative study from Turkey and Romania. LWT 2021, 149, 111925 .

AMA Style

Rodica Mărgăoan, Aslı Özkök, Şaban Keskin, Nazlı Mayda, Adriana Cristina Urcan, Mihaiela Cornea-Cipcigan. Bee collected pollen as a value-added product rich in bioactive compounds and unsaturated fatty acids: A comparative study from Turkey and Romania. LWT. 2021; 149 ():111925.

Chicago/Turabian Style

Rodica Mărgăoan; Aslı Özkök; Şaban Keskin; Nazlı Mayda; Adriana Cristina Urcan; Mihaiela Cornea-Cipcigan. 2021. "Bee collected pollen as a value-added product rich in bioactive compounds and unsaturated fatty acids: A comparative study from Turkey and Romania." LWT 149, no. : 111925.

Journal article
Published: 09 February 2021 in LWT - Food Science and Technology
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Beebread (BB) is a fermented bee product made from plant pollen, honey and bee saliva. The nutritive and biological compounds of BB vary greatly depending on the diversity of flora and the season of pollen collection by bees. In order to evaluate this valuable bee product potential, thirteen BB samples were analyzed on the nutritive proprieties and biologically active compounds, correlated with their botanical origin. The obtained results shows that BB comes with a high content of proteins with values ranging between 18.96 and 23.11 g/100 g, lipids ranging between 4.89 and 14.74 g/100 g, and free sugars, fructose being present in the highest amount (17.27 g/100 g). Analyzed samples contain all the essential amino acids, methionine being the most abundant, 86.93–12.38 mg/100 g, mono- and polyunsaturated fatty acids, ω-6/ω-3 ratio varying between 0.02 – 1.07. BB samples have also high amount of natural antioxidants, from the class of polyphenols and flavonol glycoside derivative. These findings suggest that BB could be used as a source of potential value-added nutrients and bioactive compounds and contributes to the chemical knowledge of this natural product.

ACS Style

Adriana Cristina Urcan; Adriana Dalila Criste; Daniel Severus Dezmirean; Otilia Bobiș; Victorița Bonta; Francisc Vasile Dulf; Rodica Mărgăoan; Mihaiela Cornea-Cipcigan; Maria Graça Campos. Botanical origin approach for a better understanding of chemical and nutritional composition of beebread as an important value-added food supplement. LWT - Food Science and Technology 2021, 142, 111068 .

AMA Style

Adriana Cristina Urcan, Adriana Dalila Criste, Daniel Severus Dezmirean, Otilia Bobiș, Victorița Bonta, Francisc Vasile Dulf, Rodica Mărgăoan, Mihaiela Cornea-Cipcigan, Maria Graça Campos. Botanical origin approach for a better understanding of chemical and nutritional composition of beebread as an important value-added food supplement. LWT - Food Science and Technology. 2021; 142 ():111068.

Chicago/Turabian Style

Adriana Cristina Urcan; Adriana Dalila Criste; Daniel Severus Dezmirean; Otilia Bobiș; Victorița Bonta; Francisc Vasile Dulf; Rodica Mărgăoan; Mihaiela Cornea-Cipcigan; Maria Graça Campos. 2021. "Botanical origin approach for a better understanding of chemical and nutritional composition of beebread as an important value-added food supplement." LWT - Food Science and Technology 142, no. : 111068.

Review
Published: 01 September 2020 in Processes
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Recently, an increasing interest is paid to bee products obtained as a result of the fermentation process. Some of them can be consumed directly (bee-collected pollen, honey, bee bread etc.), while others are the result of lactic and/or acid fermentation (honey vinegar and honey wine). Bee bread is the result of pollens’ lactic fermentation, whereas mead is obtained by honeys’ lactic fermentation. Moreover, as a result of honey acetic acid fermentation, honey vinegar is obtained. Sensory characteristics and aroma composition have been scarcely studied, which may depend on the starter culture and fermentation process. Along with the medicinal properties they are a vital resource for future researches as they are of particular importance in the food market. In this review, we discuss the aroma-active compounds, taste, and sensorial characteristics of fermented bee products along with the approaches that can be developed for the flavor improvement based on existing technologies. Furthermore, the beneficial effects on human health are also described, with special attention that should be attributed to finding the use of probiotics in these fermented products as health-promoting effects.

ACS Style

Rodica Mărgăoan; Mihaiela Cornea-Cipcigan; Erkan Topal; Mustafa Kösoğlu. Impact of Fermentation Processes on the Bioactive Profile and Health-Promoting Properties of Bee Bread, Mead and Honey Vinegar. Processes 2020, 8, 1081 .

AMA Style

Rodica Mărgăoan, Mihaiela Cornea-Cipcigan, Erkan Topal, Mustafa Kösoğlu. Impact of Fermentation Processes on the Bioactive Profile and Health-Promoting Properties of Bee Bread, Mead and Honey Vinegar. Processes. 2020; 8 (9):1081.

Chicago/Turabian Style

Rodica Mărgăoan; Mihaiela Cornea-Cipcigan; Erkan Topal; Mustafa Kösoğlu. 2020. "Impact of Fermentation Processes on the Bioactive Profile and Health-Promoting Properties of Bee Bread, Mead and Honey Vinegar." Processes 8, no. 9: 1081.

Journal article
Published: 03 April 2020 in Agronomy
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Cyclamen species (swinebread spp.) are perennial herbaceous plants which belong to the Primulaceae family, widely used as medicinal or ornamental plants. Currently, gibberellic acid (GA3), an environmentally friendly bioregulator is widely used to enhance the productivity and phenotypic characteristics of multiple ornamental crops. A dual experiment was conducted to evaluate the influence of gibberellic acid (50, 100 or 150 mg/L), on germination earliness of seeds, along with growth and ornamental quality of selected Cyclamen species. Additionally, a greenhouse experiment with long and short sunlight photoperiod was conducted to evaluate its importance in the development of Cyclamen plants. Our results indicated that under short sunlight exposure, seeds germinated earlier than those kept in long sunlight photoperiod. Plants treated with foliar applications of GA3 exhibited higher plant height, leaf area, number of leaves, root length and tuber development. Significant differences were found in germination percentage (GP), mean germination time (MGT) and seedling vigor index (SVI), within different GA3 supplementation and greenhouse sunlight intensity (short and long days). In conclusion, our study suggests that seedling vigor and ornamental quality can be increased by GA3 application, an economic strategy for enhancing germination and growth of selected Cyclamen species.

ACS Style

Mihaiela Cornea-Cipcigan; Doru Pamfil; Cristian Radu Sisea; Rodica Mărgăoan. Gibberellic Acid Can Improve Seed Germination and Ornamental Quality of Selected Cyclamen Species Grown Under Short and Long Days. Agronomy 2020, 10, 516 .

AMA Style

Mihaiela Cornea-Cipcigan, Doru Pamfil, Cristian Radu Sisea, Rodica Mărgăoan. Gibberellic Acid Can Improve Seed Germination and Ornamental Quality of Selected Cyclamen Species Grown Under Short and Long Days. Agronomy. 2020; 10 (4):516.

Chicago/Turabian Style

Mihaiela Cornea-Cipcigan; Doru Pamfil; Cristian Radu Sisea; Rodica Mărgăoan. 2020. "Gibberellic Acid Can Improve Seed Germination and Ornamental Quality of Selected Cyclamen Species Grown Under Short and Long Days." Agronomy 10, no. 4: 516.

Review
Published: 29 December 2019 in Acta Poloniae Pharmaceutica - Drug Research
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ACS Style

Mihaiela Cornea-Cipcigan; Doru Pamfil; Cristian Sisea; Cornelia Gavriș; Maria Da Graça Ribeiro Campos; Rodica Mărgăoan. A REVIEW ON CYCLAMEN SPECIES: TRANSCRIPTION FACTORS VS. PHARMACOLOGICAL EFFECTS. Acta Poloniae Pharmaceutica - Drug Research 2019, 76, 919 -938.

AMA Style

Mihaiela Cornea-Cipcigan, Doru Pamfil, Cristian Sisea, Cornelia Gavriș, Maria Da Graça Ribeiro Campos, Rodica Mărgăoan. A REVIEW ON CYCLAMEN SPECIES: TRANSCRIPTION FACTORS VS. PHARMACOLOGICAL EFFECTS. Acta Poloniae Pharmaceutica - Drug Research. 2019; 76 (6):919-938.

Chicago/Turabian Style

Mihaiela Cornea-Cipcigan; Doru Pamfil; Cristian Sisea; Cornelia Gavriș; Maria Da Graça Ribeiro Campos; Rodica Mărgăoan. 2019. "A REVIEW ON CYCLAMEN SPECIES: TRANSCRIPTION FACTORS VS. PHARMACOLOGICAL EFFECTS." Acta Poloniae Pharmaceutica - Drug Research 76, no. 6: 919-938.

Review
Published: 20 November 2019 in Antioxidants
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Bee products were historically used as a therapheutic approach and in food consumption, while more recent data include important details that could validate them as food supplements due to their bioproperties, which support their future use as medicines. In this review data, data collected from bee pollen (BP) and bee bread (BB) essays will be discussed and detailed for their nutritional and health protective properties as functional foods. Dietary antioxidants intake derived from BP and BB have been associated with the prevention and clinical treatment of multiple diseases. The beneficial effects of BP and BB on health result from the presence of multiple polyphenols which possess anti-inflammatory properties, phytosterols and fatty acids, which play anticancerogenic roles, as well as polysaccharides, which stimulate immunological activity. From the main bioactivity studies with BP and BB, in vitro studies and animal experiments, the stimulation of apoptosis and the inhibition of cell proliferation in multiple cell lines could be one of the major therapeutic adjuvant effects to be explored in reducing tumor growth. Tables summarizing the main data available in this field and information about other bio-effects of BP and BB, which support the conclusions, are provided. Additionally, a discussion about the research gaps will be presented to help further experiments that complete the tree main World Health Organization (WHO) Directives of Efficiency, Safety and Quality Control for these products.

ACS Style

Rodica Mărgăoan; Mirela Stranț; Alina Varadi; Erkan Topal; Banu Yücel; Mihaiela Cornea-Cipcigan; Maria G. Campos; Dan C. Vodnar. Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits. Antioxidants 2019, 8, 568 .

AMA Style

Rodica Mărgăoan, Mirela Stranț, Alina Varadi, Erkan Topal, Banu Yücel, Mihaiela Cornea-Cipcigan, Maria G. Campos, Dan C. Vodnar. Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits. Antioxidants. 2019; 8 (12):568.

Chicago/Turabian Style

Rodica Mărgăoan; Mirela Stranț; Alina Varadi; Erkan Topal; Banu Yücel; Mihaiela Cornea-Cipcigan; Maria G. Campos; Dan C. Vodnar. 2019. "Bee Collected Pollen and Bee Bread: Bioactive Constituents and Health Benefits." Antioxidants 8, no. 12: 568.

Review
Published: 12 June 2019 in Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture
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Nowadays, the field of entirely artificial hybrids raises ethical problems in the animal world and to a lesser amount in plants. Throughout the years, yellow Cyclamen has been particularly important for both breeders and passionate growers as being a peculiar color for this species. The possibility to artificially induce hybrids between species that can never normally cross it’s now achievable. This paper describes the possibility of obtaining high ornamental yellow flowered cyclamen, through chromosome doubling. The pollen and seed sterility can be overcome by doubling the chromosomes. In this sense, there are two full sets from each parent, resulting in a fertile hybrid, by introducing the in vitro culture into colchicine supplemented medium.

ACS Style

Mihaiela Cornea-Cipcigan; Doru Pamfil. Expression Effects of CHI and CHS Genes and Colchicine Treatment in Yellow Flowered Cyclamen: a Review. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture 2019, 76, 1 -10.

AMA Style

Mihaiela Cornea-Cipcigan, Doru Pamfil. Expression Effects of CHI and CHS Genes and Colchicine Treatment in Yellow Flowered Cyclamen: a Review. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture. 2019; 76 (1):1-10.

Chicago/Turabian Style

Mihaiela Cornea-Cipcigan; Doru Pamfil. 2019. "Expression Effects of CHI and CHS Genes and Colchicine Treatment in Yellow Flowered Cyclamen: a Review." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Horticulture 76, no. 1: 1-10.