Dr. Annamaria Altomare

Campus Bio-Medico University of Rome

Dr. Annamaria Altomare

Campus Bio-Medico University of Rome

Co-authors

Following

Followers

Research Focus & Metrics

Explore full metrics on Scilit

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications

31 January 2020 in Nutrients

Journal Article

Nutritional Aspects in Inflammatory Bowel Diseases

Paola Balestrieri

Mentore Ribolsi

Michele Pier Luca Guarino

Sara Emerenziani

Annamaria Altomare

Michele Cicala

Crohn’s disease (CD) and ulcerative colitis (UC) are chronic, relapsing, inflammatory disorders of the digestive tract that characteristically develop in adolescence and early adulthood. The reported prevalence of malnutrition in inflammatory bowel disease (IBD) patients ranges between 20% and 85%. Several factors, including reduced oral food intake, malabsorption, chronic blood and proteins loss, and intestinal bacterial overgrowth, contribute to malnutrition in IBD patients. Poor nutritional status, as well as selective malnutrition or sarcopenia, is associated with poor clinical outcomes, response to therapy and, therefore, quality of life. The nutritional assessment should include a dietetic evaluation with the assessment of daily caloric intake and energy expenditure, radiological assessment, and measurement of functional capacity.

9 April 2020 in Nutrients

Journal Article

Mechanisms of Action of Prebiotics and Their Effects on Gastro-Intestinal Disorders in Adults

Michele Pier Luca Guarino

In recent years, research has focused on the use of dietary fibers and prebiotics, since many of these polysaccharides can be metabolized by intestinal microbiota, leading to the production of short-chain fatty acids. The metabolites of prebiotic fermentation also show anti-inflammatory and immunomodulatory capabilities, suggesting an interesting role in the treatment of several pathological conditions. Galacto-oligosaccharide and short- and long-chain fructans (Fructo-oligosaccharides and inulin) are the most studied prebiotics, even if other dietary compounds seem to show the same features. There is an increasing interest in dietary strategies to modulate microbiota. The aim of this review is to explore the mechanisms of action of prebiotics and their effects on the principal gastro-intestinal disorders in adults, with a special focus on Galacto-oligosaccharides, Fructo-oligosaccharides, lactulose and new emerging substances which currently have evidence of prebiotics effects, such as xilooligosaccharides, soybean oligosaccharides, isomaltooligosaccharides, lactobionic acid, resistant starch and polyphenols.

31 December 2019 in Nutrients

Journal Article

Role of Overweight and Obesity in Gastrointestinal Disease

Sara Emerenziani

Michele Pier Luca Guarino

Laura Maria Trillo Asensio

Annamaria Altomare

Mentore Ribolsi

Michele Cicala

The prevalence of obesity is increasing worldwide, leading to a severe impairment of overall health. Actually, obesity has been associated with several pathological conditions, causing an excess overall mortality. In particular, overweight and obesity are well known risk factors for a variety of gastrointestinal (GI) disorders i.e., functional GI disorders as well as, inflammatory bowel disease (IBD), pancreatitis, and GI cancer. The aim of the present review is to summarize the potential role of overweight and obesity in GI disease with particular focus on plausible biological mechanisms that could explain the association between obesity and GI disease based on the most recent evidence in the literature.

25 March 2010 in Neurogastroenterology & Motility

Journal Article

Increased TRPV1 gene expression in esophageal mucosa of patients with non-erosive and erosive reflux disease

Michele Pier Luca Guarino

L. Cheng

J. Ma

K. Harnett

P. Biancani

Michele Cicala

29 April 2021 in Nutrients

Journal Article

Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

Michele Pier Luca Guarino

Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. Gut microbiota, which acts as a real organ with well-defined functions, is in a mutualistic relationship with the host, harvesting additional energy and nutrients from the diet and protecting the host from pathogens; specific alterations in its composition seem to play a crucial role in IBS pathophysiology. It is well known that diet can significantly modulate the intestinal microbiota profile but it is less known how different nutritional approach effective in IBS patients, such as the low-FODMAP diet, could be responsible of intestinal microbiota changes, thus influencing the presence of gastrointestinal (GI) symptoms. The aim of this review was to explore the effects of different nutritional protocols (e.g., traditional nutritional advice, low-FODMAP diet, gluten-free diet, etc.) on IBS-D symptoms and on intestinal microbiota variations in both IBS-D patients and healthy subjects. To date, an ideal nutritional protocol does not exist for IBS-D patients but it seems crucial to consider the effect of the different nutritional approaches on the intestinal microbiota composition to better define an efficient strategy to manage this functional disorder.

29 September 2008 in Clinical and Experimental Immunology

Journal Article

Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms in gastric cancer of intestinal and diffuse histotypes

Santini Daniele

S. Angeletti

A. Ruzzo

G. Dicuonzo

S. Galluzzo

G. Tonini

In the present study we investigated the potential role of Toll-like receptor 4 (TLR-4) Asp299Gly and Thr399Ile polymorphisms as risk factors in the development of gastric cancer. TLR-4 Asp299Gly and Thr399Ile polymorphisms were investigated in 171 Italian patients with sporadic gastric cancer and in 151 controls. Unconditional regression (odds ratio and 95% confidence intervals) were used to investigate the association of the studied polymorphisms with gastric cancer. TLR-4 Thr399Ile polymorphism is linked with an increased susceptibility to gastric cancer (P = 0·023 and hazard ratio = 3·62). No significant association for TLR-4 Asp299Gly polymorphism was found. In the subgroup of patients with intestinal-type gastric cancer, a significant risk of gastric cancer was associated with TLR-4 Thr399Ile genotype (P = 0·006). Our results demonstrated that TLR-4 Thr399Ile polymorphism is linked with an increased susceptibility to gastric cancer. An increased risk for intestinal gastric cancer in carriers of the TLR4 Thr399Ile allele was observed. Future epidemiological studies should consider the possible interactions between proinflammatory genotypes (such as TLR and interleukin-1R polymorphisms) and other risk factors for cancer such as dietary habits and/or exposure to environmental carcinogens.

About Me

Graduated in medicine and surgery, July 2006. Postgraduate degree in gastroenterology and digestive endoscopy, September 2011. PhD in nutrition, 2015 (completed on 25 April 2015). One-year postdoctoral program in gastroenterology at the University Campus Biomedico of Rome (completed on 31 January 2017). Fellowship in basic science at Brown University, Providence, RI, between October 2009 and March 2011 (supervisor Prof. P. Biancani). Since 2004, she has been performing clinical and research activities at the Gastroenterology Unit, Campus Bio-medico University, Rome. Fields of scientific and clinical interest: gastro-oesophageal reflux disease, including pathophysiology, diagnosis and treatment; gastro-intestinal motility; functional disorders of the gastro-intestinal tract; diagnosis and treatment of inflammatory bowel disease. • Poster award, “Human Colonic Smooth muscle contractility following acute thermal cooling”, AGA Poster Session, DDW, 2012-19-22 May. • Winner of a travel grant for the abstract N° UEGW11-6398 during the UEG Week 2011, Stockholm, October 22–26. • Winner of a travel grant for the abstract N° #4427 during the UEG Week 2016, Vienna, October 15–19. • Recognition as early career investigator at DDW 2018 (Washington DC, 2-5 June) for the abstract presentation entitled “Type-1 cannabinoid receptor effect on human colonic motility in patients with slow transit constipation and controls”.

Dr. Annamaria Altomare

Dr. Annamaria Altomare

Research Focus & Metrics

Academic Career Length

Publication Type Breakdown

Representative Publications

About Me