Several studies have examined the effects of vibrations on muscle mass and performance in young healthy people. We studied the effects of vibrations on muscles of elderly male and female volunteers (65-85 years of age) diagnosed with sarcopenia. We applied mechanical vibrations locally (local vibrational training) to the thigh muscles at 300 Hz for a period of 12 weeks, starting with a session of 15 min stimulation once a week and increasing to three sessions of 15 min per week. Treated muscles displayed enhanced maximal isometric strength and increased content of fast MyHC-2X myosin. Single muscle fiber analysis did not show any change in cross-sectional area or in specific tension. Analysis of transcriptional profiles by microarray revealed changes in gene expression after 12 weeks of local vibrational training. In particular, pathways related with energy metabolism, sarcomeric protein balance and oxidative stress response were affected. We conclude that vibration treatment is effective in counteracting the loss of muscular strength associated with sarcopenia and the mode of action of vibration is based on cellular and molecular changes which do not include increase in fiber or muscle size.

The article explores the possibilities of formalizing and explaining the mechanisms that support spatial and social perspective alignment sustained over the duration of a social interaction. The basic proposed principle is that in social contexts the mechanisms for sensorimotor transformations and multisensory integration (learn to) incorporate information relative to the other actor(s), similar to the "re-calibration" of visual receptive fields in response to repeated tool use. This process aligns or merges the co-actors' spatial representations and creates a "Shared Action Space" supporting key computations of social interactions and joint actions; for example, the remapping between the coordinate systems and frames of reference of the co-actors, including perspective taking, the sensorimotor transformations required for lifting jointly an object, and the predictions of the sensory effects of such joint action. The social re-calibration is proposed to be based on common basis function maps and could constitute an optimal solution to sensorimotor transformation and multisensory integration in joint action or more in general social interaction contexts. However, certain situations such as discrepant postural and viewpoint alignment and associated differences in perspectives between the co-actors could constrain the process quite differently. We discuss how alignment is achieved in the first place, and how it is maintained over time, providing a taxonomy of various forms and mechanisms of space alignment and overlap based, for instance, on automaticity vs. control of the transformations between the two agents. Finally, we discuss the link between low-level mechanisms for the sharing of space and high-level mechanisms for the sharing of cognitive representations.

There is an on-going debate in cognitive (neuro) science and philosophy between classical cognitive theory and embodied, embedded, extended, and enactive (“4-Es”) views of cognition—a family of theories that emphasize the role of the body in cognition and the importance of brain-body-environment interaction over and above internal representation. This debate touches foundational issues, such as whether the brain internally represents the external environment, and “infers” or “computes” something. Here we focus on two (4-Es-based) criticisms to traditional cognitive theories—to the notions of passive perception and of serial information processing—and discuss alternative ways to address them, by appealing to frameworks that use, or do not use, notions of internal modelling and inference. Our analysis illustrates that: an explicitly inferential framework can capture some key aspects of embodied and enactive theories of cognition; some claims of computational and dynamical theories can be reconciled rather than seen as alternative explanations of cognitive phenomena; and some aspects of cognitive processing (e.g., detached cognitive operations, such as planning and imagination) that are sometimes puzzling to explain from enactive and non-representational perspectives can, instead, be captured nicely from the perspective that internal generative models and predictive processing mediate adaptive control loops.