Urban land expansion (ULE) has caused negative effects as a result of urbanization and industrialization in China in the past few decades. Strengthening economic linkage and the cooperation among regions has great implications for effectively controlling disorderly ULE and achieving sustainable and intensive land use. Previous research has rarely investigated the relationship between ULE and economic linkage. Therefore, this study analyzes the spatial patterns of ULE and economic linkage in the Yangtze River Economic Belt (YREB) of China via social network analysis and a gravity model. Moreover, the spatial relationship and coupling level between ULE and economic linkage are investigated by building a bivariate spatial autocorrelation model and a coupling coordination degree model, respectively. The results indicate that the YREB experienced rapid ULE, and the area increased from 4.24 × 10⁴ km² in 1990 to 7.89 × 10⁴ km² in 2015. The cities that experience rapid ULE have gradually transferred from the east to the west of the YREB. In addition, the economic linkage in eastern cities is evidently higher than that of western cities. Our bivariate spatial model further proves that there are strong negative spatial correlation characteristics between ULE and economic linkage. This indicates that the higher the economic linkage, the lower the speed of ULE. Moreover, the coupling coordination between ULE and economic linkage show that the overall coupling stage changed from an antagonistic stage to a running-in stage. However, the coupling coordination in the YREB presented significant spatial heterogeneity, and most cities in urban agglomeration had a relationship between ULE and economic linkage that was barely balanced, slightly unbalanced, or seriously unbalanced. By considering the limitations and obstacles of current initiatives, suggestions and policy implications for sustainable land use at large regional scales are suggested.