Background: Food addiction and an impulsive personality can increase overeating, which can lead to weight gain. The amygdala and nucleus accumbens (NAcc) are critical for regulating obesogenic behaviour. However, whether the amygdala or the NAcc acts as the neural basis for the regulation of food addiction, impulsive personality, and body weight remains unclear.Methods: We examined the differences in the volume of the amygdala and NAcc, especially the lateralization index (LI), between 33 obese participants and 39 age- and sex-matched healthy controls. The associations of the LI of each brain region with clinical variables and body mass index (BMI) were identified using network analysis. Finally, we explored the relationships among the LIs of brain regions, impulsive personality, food addiction, and BMI through a multiple chain mediation model.Results: We observed a significant decrease in the LI of the amygdala in the obese group compared with the healthy group (F = 20.276, p < 0.001), which indicates that the right amygdala was larger than the left amygdala in the obese group. Network analysis revealed that the LI of the amygdala was very closely associated with nonplanning impulsivity, food addiction and BMI. The results of the mediation analysis indicated that increased nonplanning impulsiveness could lead to weight gain through increased food addiction (β = 0.069, SE = 0.043, 95% CI [0.014, 0.184]). Moreover, in this symptom chain, the LI of the amygdala can mediate the relationship between food addiction and BMI (β = 0.018, SE = 0.014, 95% CI [0.002, 0.061]).Conclusion: Our observations indicate a substantial reduction in the LI of the amygdala among individuals with obesity, suggesting a structural predisposition. The findings reveal a potential neural mechanism that can help explain the interplay between impulsivity, food addiction, and obesity.

Cyclin-dependent kinase 12 (CDK12) mutation has been shown to be associated with the prognosis and clinicopathological characteristics of various tumors. The aim of this meta-analysis was to invest...

Obesity demonstrates bidirectional associations with anxiety, depression and sleep quality. Although bariatric surgery effectively alleviates obesity-related mental health issues, the mechanisms and temporal dynamics of mental symptom improvements remain unclear. This longitudinal study aims to explore the time points at which mental health and sleep quality change after bariatric surgery in overweight/obese patients, and explore correlation between anxiety, depression and sleep quality. Seventy-eight overweight/obese patients (OW/OB) who underwent Laparoscopic sleeve gastrectomy at the Bariatric Center of Shanghai Sixth People’s Hospital were included by cohort. Sixty-five healthy controls (HC) were matched by age and sex. Patients received Chinese versions of the Beck Depression Inventory II (BDI), Beck Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI) completed during monthly follow-up surveys after surgery. Before surgery, the OW/OB group had significantly worse anxiety, depression, and sleep problems than HC (all p < 0.001). After surgery, BAI and PSQI scores decreased significantly at all time points, and BDI scores began to decrease at 1 year postoperatively compared with baseline (all p < 0.05). There was a stable positive correlation between preoperative body mass index, BAI, BDI, and PSQI scores, which broke down in the postoperative period. Bariatric surgery improved anxiety symptoms and sleep quality in overweight or obese patients, while depressive symptoms showed delayed but statistically significant improvements at later follow-up points. Stable associations between anxiety, depression, and sleep quality in overweight or obese patients may require multiple interventions.