Maria Rosaria De Miglio is an associate professor of the Department Medicine, Surgery and Pharmacy at the University of Sassari. She has been involved in the drafting and management, both as a leader and collaborator, of various regional and national research projects eligible for funding. She has received grants from the MIUR, the Regional Government, and Foundations. She is currently a member of the Board of Teachers of the School of Doctorate in Biomolecular and Biotechnological Sciences. She has also been involved as an editorial board member (Frontiers in Oncology, Scientific Reports, Medicina, Technology in Cancer Research and Treatment) and as a reviewer for numerous journals. Recently, her scientific interests have been focused on the integration of multi-omics approaches for the study of colorectal cancer, performing transcriptome analysis studies via innovative massive sequencing approaches that include the epigenetic deregulation involved in its pathogenesis. Another area of interest involves the identification of diagnostic, prognostic, and predictive biomarkers in cancer; the recent results of these projects have allowed us to determine that PIK3CA gene mutations and PI3K/AKT pathway activation are common events in the “Triple Negative” breast cancer (TNBC) subtype, such as to demonstrate that a miRNA signature given by miR-135b is strictly related to TNBC with the basal-like phenotype.