This study aimed to compare whether differences in lifestyle and dietary habits have an impact on hyperuricemia and to provide a reliable basis for the health management of citizens in our city. A total of 10,883 subjects who did not suffer from hyperuricemia, was anticipated in this study in 2018. After 2 years of follow-up, 7727 did not suffer from hyperuricemia and 3156 suffered from hyperuricemia. Dietary habits and lifestyle were collected by questionnaire. Multivariate logistic regression was used to identify the risk factors of hyperuricemia. For the analysis of the amount of change in uric acid (UA) before and after 2 years, t-tests and spearman correlation were used to explore the differences between the groups, and the trend effect of each variable on the amount of change in uric acid was analyzed by linear regression equations. The results showed that the prevalence of hyperuricemia varied by sex, high-fat food, smoked and fried food, milk and soy products, sugary drinks, sleep time, and the degree of smoking and drinking. Among them, infrequent consumption of milk and soy products, and short sleep time were risk factors for hyperuricemia, and men were more likely to have elevated uric acid levels after 2 years. It is recommended that people with hyperuricemia should actively limit their intake of fried foods, alcohol, and purine-rich foods, increase their intake of milk and soy foods, increase their sleep time, and seek to improve kidney and liver function.

To investigate the dampness syndrome score in hypertriglyceridemia and the correlations between hypertriglyceridemia and other chronic diseases and lifestyle factors. Data were retrospectively obtained from individuals who underwent physical examinations at Guangzhou Cadres Health Management Centre from May 2022 to May 2023. t Test, variance analysis, and chi-square test were used to compare the score of dampness syndrome and the prevalence of hypertriglyceridemia among different subgroups. Pearson, Spearman correlation analysis, and regression analysis were used to explore the correlations between hypertriglyceridemia and dampness syndrome, chronic diseases, and lifestyle factors. The prevalence of hypertriglyceridemia was 26.70%. Clinical test index and dampness syndrome score were significant differences between hypertriglyceridemia group and normal group (P < .05). Subgroup analyses as a function of the degree of triglyceridemia indicated that the dampness syndrome score increased with increasing degree of triglyceridemia (P < .05). Correlation analysis showed that hypertriglyceridemia was correlated with dampness syndrome, overweight/obesity, hypertension, diabetes, and other chronic diseases (P < .05). Multivariate logistic regression analysis showed that age, sex, marriage, education level, smoking, drinking, fruit consumption, vegetable consumption, milk and dairy product consumption, dessert or snack consumption, the degree of dampness syndrome, and engagement in exercise were associated with hypertriglyceridemia (P < .05). Hypertriglyceridemia is associated with a variety of chronic diseases and lifestyle factors, and is closely related to dampness syndrome. The score of dampness syndrome can reflect hypertriglyceridemia to a certain extent. It provides more clinical reference for the treatment of hypertriglyceridemia combined with the analysis of dampness syndrome of traditional Chinese medicine.

To explore the relationship between the incidence of colorectal polyps and related factors such as markers of insulin resistance (IR) , a retrospective analysis was used to collect 2716 patients who underwent physical examinations in Guangzhou Cadre and Talent Health Management Center from June 2020 to June 2023. The patients were classified as colorectal polyp group (n = 1328) and non-polyp group (n = 1388) after colonoscopy. Baseline data of colorectal polyp and non-polyp groups were compared. Non-insulin-based IR markers including Triglyceride Glucose Index (TyG), triglyceride glucose index (TyG)- Body Mass Index(BMI), triglycerides (TG)/high density lipoprotein cholesterol (HDL-C), Metabolic Score for Insulin Resistance (METS-IR), and mean arterial pressure (MAP) were calculated. The risk factors of colorectal polyps were analyzed by binary logistic regression. Receiver operating characteristic (ROC) curves and area under the curve (AUC) were used to evaluate the ability of insulin resistance markers to detect colorectal polyps. The proportion of males in colorectal polyp group was higher than that in non-polyp group. There were significant differences in TyG-BMI, TyG, TG/HDL-C, METS-IR, MAP, and other indicators between the colorectal polyp group and the non-polyp group (p < 0.05). Binary logistic regression analysis showed that elevation in age, BMI, TyG-BMI, TyG, TG/HDL-C, METS-IR, MAP and CEA were positively correlated with the risk of colorectal polyps (p < 0.05). The AUCs of insulin resistance markers and MAP were larger than CEA to detect colorectal polyps. The AUC values of models in combination of age, sex and insulin resistance markers/MAP is higher. TyG, TyG-BMI, TG/HDL-C, and METS-IR could be used as indicators to predict the occurrence of colorectal polyps. These findings provide an important clinical reference for the prevention and treatment of colorectal polyps.

Background: Diabetes mellitus-induced erectile dysfunction (DMED) involves complex pathophysiology, leading to suboptimal outcomes with phosphodiesterase type 5 inhibitors (PDE5I) alone. Combining PDE5I with traditional Chinese medicine (TCM) may enhance therapeutic efficacy, but evidence synthesis is lacking. Therefore, this systematic review and meta-analysis aims to compare the efficacy and safety of PDE5I combined with TCM versus PDE5I monotherapy in DMED management. Methods: We conducted a systematic review and meta-analysis following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines (PROSPERO: CRD42021240608). Six databases (PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure Database, Wanfang, and VIP Science Technology Periodical Database) were searched up to May 10, 2024. Randomized controlled trials (RCTs) evaluating PDE5I + TCM versus PDE5I alone in DMED patients with International Index of Erectile Function-5 (IIEF-5) ≤ 21 were included. Data extraction, risk of bias assessment (Cochrane tool), and meta-analysis (RevMan 5.3) were performed using fixed/random-effects models. Outcomes included clinical efficacy, IIEF-5 scores, TCM syndrome scores, and adverse events. Results: Twelve RCTs (1070 participants) were included. PDE5I + TCM significantly improved clinical efficacy (relative risk = 2.86, 95% confidence interval [CI] [2.13, 3.84], P < .001) compared to PDE5I alone. Subgroup analysis showed higher IIEF-5 scores for tadalafil + TCM (standardized mean difference [SMD] = 1.07, 95% CI [0.85, 1.30], P < .001) and sildenafil + TCM (SMD = 1.38, 95% CI [1.11, 1.65], P < .001). TCM syndrome scores decreased significantly with combination therapy (tadalafil + TCM: SMD = -3.43, 95% CI [-3.93, -2.94]; sildenafil + TCM: SMD = -1.40, 95% CI [-1.77, -1.03]). Adverse event rates (dizziness, gastrointestinal effects, flushing) did not differ between groups (all P > .05). Conclusion: This study demonstrates that PDE5I combined with TCM demonstrates superior efficacy in improving erectile function and TCM symptom profiles in DMED patients, without increasing adverse events. However, limitations such as variability in TCM formulations and treatment durations across studies, as well as unclear blinding protocols in some trials, may introduce heterogeneity and affect the generalizability of these findings. Further high-quality RCTs are needed to validate optimal regimens and long-term outcomes.

This study aims to investigate the relationship between the occurrence of breast nodules at different stages and the physical examination indicators, lifestyle habits, and environmental factors in perimenopausal women aged 40 to 60 years in 2022. In total, 3293 samples were obtained by comprehensively analyzing the data from laboratory examinations, breast imaging, and questionnaires. A one-way ANOVA test or rank sum test was applied to explore the differences among groups, and multifactorial logistic regression analysis was used to determine the influencing factors of breast nodules. The results revealed that the lymphocyte percentage was negatively associated with breast nodules of BI-RADS category 4. Low-density lipoprotein was more likely to increase the occurrence of breast nodules belonging to BI-RADS category 3 and BI-RADS category 4. Less work stress may be associated with fewer breast nodules of BI-RADS category 3. Air conditioning for 2 to 4 hours/day in the summer is more likely to increase the breast nodules of BI-RADS category 2. This study preliminarily explored the effects of clinical indicators, environment, and healthy lifestyle habits on breast nodules, offering empirical support for breast disease management and personalized interventions that are expected to reduce the risks of breast nodules in perimenopausal women.

Introduction: Metabolic syndrome (MetS) is an important cardiometabolic risk condition among working-age adults, but evidence on its burden, component patterns, and lifestyle correlates among office-based occupational populations in southern China remains limited. Methods: This cross-sectional study identified 22,156 adults undergoing routine health examinations in Guangzhou, China, in 2023. Primary descriptive and multivariable analyses were conducted among 11,291 participants with complete biochemical, anthropometric, and questionnaire data. MetS was defined according to the International Diabetes Federation 2005 criteria. Multiple imputation by chained equations was performed as a sensitivity analysis using the full eligible cohort, and a fully adjusted BMI-adjusted model was additionally fitted within the imputed datasets. Results: In the complete-case sample, MetS prevalence was 13.8%. Elevated blood pressure was the most frequent abnormal component, followed by elevated triglycerides, elevated fasting glucose, central obesity, and reduced HDL-C. In the primary complete-case multivariable analysis, sufficient physical activity was inversely associated with MetS (OR = 0.85, 95% CI: 0.75–0.96). This association was consistent in the multiple-imputation sensitivity analysis (OR = 0.80, 95% CI: 0.72–0.89) and in the fully adjusted BMI-adjusted sensitivity model (OR = 0.80, 95% CI: 0.70–0.91). Discussion: MetS was common in this occupational routine-examination cohort. Elevated blood pressure was the most frequent abnormal component, and physical activity was the most consistent lifestyle correlate. These findings support workplace-based physical activity promotion and cardiometabolic risk management as potential priorities for similar office-based occupational populations.