Liang Li

Dr. Liang Li

orcid

Research Focus & Metrics

Academic Career Length

32Years (1995-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2022 in Nature Microbiology
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Journal Article
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MMMary Ann Moran
Mary Ann Moran
EKElizabeth B. Kujawinski
Elizabeth B. Kujawinski
WSWilliam F. Schroer
William F. Schroer
SAShady A. Amin
Shady A. Amin
NBNicholas R. Bates
Nicholas R. Bates
AVAssaf Vardi
Assaf Vardi

1 January 2016 in Journal of Chromatography A
Verified
Journal Article
Closed access
YWYiman Wu
Yiman Wu
LLLiang Li
Liang Li

14 January 2021 in Nutrients
Verified
Journal Article
Open access
PDF file
LWLi Wu
Li Wu
YHYuqiu Han
Yuqiu Han
ZZZhipeng Zheng
Zhipeng Zheng
GPGuoping Peng
Guoping Peng
PLPing Liu
Ping Liu
BWBaohong Wang
Baohong Wang
Intimate metabolic host–microbiome crosstalk regulates immune, metabolic, and neuronal response in health and disease, yet remains untapped for biomarkers or intervention for disease. Our recent study identified an altered microbiome in patients with pre-onset amnestic mild cognitive impairment (aMCI) and dementia Alzheimer’s disease (AD). Thus, we aimed to characterize the gut microbial metabolites among AD, aMCI, and healthy controls (HC). Here, a cohort of 77 individuals (22 aMCI, 27 AD, and 28 HC) was recruited. With the use of liquid-chromatography/gas chromatography mass spectrometry metabolomics profiling, we identified significant differences between AD and HC for tryptophan metabolites, short-chain fatty acids (SCFAs), and lithocholic acid, the majority of which correlated with altered microbiota and cognitive impairment. Notably, tryptophan disorders presented in aMCI and SCFAs decreased progressively from aMCI to AD. Importantly, indole-3-pyruvic acid, a metabolite from tryptophan, was identified as a signature for discrimination and prediction of AD, and five SCFAs for pre-onset and progression of AD. This study showed fecal-based gut microbial signatures were associated with the presence and progression of AD, providing a potential target for microbiota or dietary intervention in AD prevention and support for the host–microbe crosstalk signals in AD pathophysiology.

1 February 2013 in Analytical Chemistry
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Journal Article
Closed access
LLLiang Li
Liang Li
RLRonghong Li
Ronghong Li
JZJianjun Zhou
Jianjun Zhou
AZAzeret Zuniga
Azeret Zuniga
ASAvalyn E. Stanislaus
Avalyn E. Stanislaus
GLGuohui Lin
Guohui Lin

1 October 2020 in TrAC Trends in Analytical Chemistry
Verified
Journal Article
Closed access
SZShuang Zhao
Shuang Zhao
LLLiang Li
Liang Li