Dr. Marie Potier-Cartereau

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Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 April 2016 in Oncotarget

Journal Article

SK3/TRPC1/Orai1 complex regulates SOCE-dependent colon cancer cell migration: a novel opportunity to modulate anti-EGFR mAb action by the alkyl-lipid Ohmline

Maxime Guéguinou

Thomas Harnois

David Crottes

Arnaud Uguen

Nadine Deliot

Marie Potier-Cartereau

+13

SK3/TRPC1/Orai1 complex regulates SOCE- dependent colon cancer cell migration: a novel opportunity to modulate Anti- EGFR mAb action by the alkyl-lipid Ohmline

12 February 2020 in Cells

Journal Article

Mitochondrial Calcium Regulation of Redox Signaling in Cancer

Céline Delierneux

Sana Kouba

Santhanam Shanmughapriya

Marie Potier-Cartereau

Mohamed Trebak

Nadine Hempel

Calcium (Ca²⁺) uptake into the mitochondria shapes cellular Ca²⁺ signals and acts as a key effector for ATP generation. In addition, mitochondria-derived reactive oxygen species (mROS), produced as a consequence of ATP synthesis at the electron transport chain (ETC), modulate cellular signaling pathways that contribute to many cellular processes. Cancer cells modulate mitochondrial Ca²⁺ ([Ca²⁺]m) homeostasis by altering the expression and function of mitochondrial Ca²⁺ channels and transporters required for the uptake and extrusion of mitochondrial Ca²⁺. Regulated elevations in [Ca²⁺]m are required for the activity of several mitochondrial enzymes, and this in turn regulates metabolic flux, mitochondrial ETC function and mROS generation. Alterations in both [Ca²⁺]m and mROS are hallmarks of many tumors, and elevated mROS is a known driver of pro-tumorigenic redox signaling, resulting in the activation of pathways implicated in cellular proliferation, metabolic alterations and stress-adaptations. In this review, we highlight recent studies that demonstrate the interplay between [Ca²⁺]m and mROS signaling in cancer.

1 July 2019 in Cell Calcium

Journal Article

Lipid metabolism and Calcium signaling in epithelial ovarian cancer

Sana Kouba

Lobna Ouldamer

Céline Garcia

Delphine Fontaine

Aurélie Chantome

Marie Potier-Cartereau

11 November 2022 in Cell Calcium

Journal Article

Calcium signaling: A therapeutic target to overcome resistance to therapies in cancer

Marie Potier-Cartereau

6 July 2020 in International Journal of Molecular Sciences

Journal Article

Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression

Hypoxia is a well-established feature of prostate cancer (PCa) and is associated with disease aggressiveness. The hypoxic microenvironment initiates multiple adaptive responses including epithelial-to-mesenchymal transition (EMT) and a remodeling of calcium homeostasis involved in cancer progression. In the present study, we identified a new hypoxia signaling pathway with a positive feedback loop between the EMT transcription factor Zeb1 and SK3, a Ca²⁺-activated K+ channel, which leads to amplifying store-operated Ca²⁺ entry. Zeb1 and SK3 channel were strongly upregulated by hypoxia both in vitro and ex vivo in organotypic cultures of human PCa. Taking into account the sensitivity of the SK3 channel to the membrane lipid composition, we identified lipids such as Ohmline (an alkyl ether lipid and SK3 inhibitor), linoleic acid (LA) and eicosapentaenoic acid (EPA) (fatty acids associated with indolent PCa), which were able to completely abrogate the hypoxia-induced changes in Zeb1 expression. Ultimately, better understanding of this new hypoxia-induced EMT pathway may allow to develop adjuvant therapeutic strategies, in order to control PCa aggressiveness and improve treatment outcomes.

18 November 2019 in Cancers

Journal Article

A Novel Calcium-Mediated EMT Pathway Controlled by Lipids: An Opportunity for Prostate Cancer Adjuvant Therapy

The composition of periprostatic adipose tissue (PPAT) has been shown to play a role in prostate cancer (PCa) progression. We recently reported an inverse association between PCa aggressiveness and elevated PPAT linoleic acid (LA) and eicosapentaenoic acid (EPA) content. In the present study, we identified a new signaling pathway with a positive feedback loop between the epithelial-to-mesenchymal transition (EMT) transcription factor Zeb1 and the Ca²⁺-activated K⁺ channel SK3, which leads to an amplification of Ca²⁺ entry and cellular migration. Using in vitro experiments and ex vivo cultures of human PCa slices, we demonstrated that LA and EPA exert anticancer effects, by modulating Ca²⁺ entry, which was involved in Zeb1 regulation and cancer cellular migration. This functional approach using human prostate tumors highlights the clinical relevance of our observations, and may allow us to consider the possibility of targeting cancer spread by altering the lipid microenvironment.

About Me

Kouba, S., Ouldamer, L., Garcia, C., Fontaine, D., Chantome, A., Vandier, C., Goupille, C., & Potier-Cartereau, M. (2019). Lipid metabolism and Calcium signaling in epithelial ovarian cancer. Cell calcium, 81, 38–50. Kouba, S., Braire, J., Félix, R., Chantôme, A., Jaffrès, P. A., Lebreton, J., Dubreuil, D., Pipelier, M., Zhang, X., Trebak, M., Vandier, C., Mathé-Allainmat, M., & Potier-Cartereau, M. (2020). Lipidic synthetic alkaloids as SK3 channel modulators. Synthesis and biological evaluation of 2-substituted tetrahydropyridine derivatives with potential anti-metastatic activity. European journal of medicinal chemistry, 186, 111854. https://doi.org/10.1016/j.ejmech.2019.111854 Guéguinou, M., Felix, R., Marionneau-Lambot, S., Oullier, T., Penna, A., Kouba, S., Gambade, A., Fourbon, Y., Ternant, D., Arnoult, C., Simon, G., Bouchet, A. M., Chantôme, A., Harnois, T., Haelters, J. P., Jaffrès, P. A., Weber, G., Bougnoux, P., Carreaux, F., Mignen, O., … Potier-Cartereau, M. (2021). Synthetic alkyl-ether-lipid promotes TRPV2 channel trafficking trough PI3K/Akt-girdin axis in cancer cells and increases mammary tumour volume. Cell calcium, 97, 102435. Advance online publication. https://doi.org/10.1016/j.ceca.2021.102435

Dr. Marie Potier-Cartereau

Dr. Marie Potier-Cartereau

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Representative Publications

About Me