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nano particles synthesis and physical characterization, adsorption of nano-materials , cytotoxity of nano-materials, micro-emulsion ionic liquids ,water nano-droplets and oil nano-droplets containing hydrophilic and hydrophobic bio-compound,and polymeric nano-micelles for drug delivery
Due to their simplicity of synthesis, stability, and functionalization, low toxicity, and ease of detection, gold nanoparticles (AuNPs) are a natural choice for biomedical applications. AuNPs’ unique optoelectronic features have subsequently been investigated and used in high-tech applications such as organic photovoltaics, sensory probes, therapeutic agents, the administration of drugs in biological and medical applications, electronic devices, catalysis, etc. Researchers have demonstrated the biosynthesis of AuNPs using plants. The present study evaluates 109 plant species used in the traditional medicine of Middle East countries as new sources of AuNPs in a wide variety of laboratory environments. In this study, dried samples of bark, bulb, flower, fruit, gum, leaf, petiole, rhizome, root, seed, stamen, and above-ground parts were evaluated in water extracts. About 117 plant parts were screened from 109 species in 54 plant families, with 102 extracts demonstrating a bioreduction of Au3+ to Au0, revealing 37 new plant species in this regard. The color change of biosynthesized AuNPs to gray, violet, or red was confirmed by UV-Visible spectroscopy, TEM, FSEM, DLS, and EDAX of six plants. In this study, AuNPs of various sizes were measured from 27 to 107 nm. This study also includes an evaluation of the potency of traditional East Asian medicinal plants used in this biosynthesis of AuNPs. An environmentally safe procedure such as this could act as a foundation for cosmetic industries whose quality assessment systems give a high priority to non-chemically synthesized products. It is crucial that future optimizations are adequately documented to scale up the described process.
Mohadeseh Hassanisaadi; Gholam Bonjar; Abbas Rahdar; Sadanand Pandey; Akbar Hosseinipour; Roohollah Abdolshahi. Environmentally Safe Biosynthesis of Gold Nanoparticles Using Plant Water Extracts. Nanomaterials 2021, 11, 2033 .
AMA StyleMohadeseh Hassanisaadi, Gholam Bonjar, Abbas Rahdar, Sadanand Pandey, Akbar Hosseinipour, Roohollah Abdolshahi. Environmentally Safe Biosynthesis of Gold Nanoparticles Using Plant Water Extracts. Nanomaterials. 2021; 11 (8):2033.
Chicago/Turabian StyleMohadeseh Hassanisaadi; Gholam Bonjar; Abbas Rahdar; Sadanand Pandey; Akbar Hosseinipour; Roohollah Abdolshahi. 2021. "Environmentally Safe Biosynthesis of Gold Nanoparticles Using Plant Water Extracts." Nanomaterials 11, no. 8: 2033.
The development of drug delivery systems minimizing the side effects of conventional chemotherapy is one of the major challenges in the field of biomaterials for cancer treatment. This work reports the formulation and characterization of oil-in-water Pluronic F127 microemulsions to enhance the bioavailability of doxorubicin (DOX). The density functional theory (DFT) calculations at the M06-2X level of theory were done to study the interaction details of DOX with ethyl butyrate, sodium caprylate, and one unit of the polymeric chain of surfactant Pluronic F127 in water solution, which are used in the synthesis process. Specifically, the quantum theory of atoms in molecules (QTAIM) analysis was performed to determine the nature of interactions. The highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) energies were calculated to show the direction of charge transfer within each complex. Furthermore, the natural bond orbital (NBO) analysis was performed on the studied systems. The size of F127/DOX microemulsion was about 7.0 nm by dynamic light scattering analysis. In vitro toxicity of standard DOX and DOX-loaded microemulsions were assessed against MCF-7 and C152 (malignant) and HUVEC (non-malignant) cell lines. Intracellular lactate dehydrogenase (LDH) leakage was evaluated as an indicator of membrane integrity. In vitro assessments revealed that Pluronic F127/DOX microemulsions caused substantial morphological changes and greater cytotoxic effects than standard DOX. Pluronic F127/DOX microemulsions were injected intraperitoneally at 12 and 24 mg/kg into rats. The free (bulk) DOX group induced severe histopathological changes and significant increases in serum kidney markers and serum liver enzymes. The 24 mg/kg dose of Pluronic F127/DOX microemulsions also induced fatty changes and elevation of serum liver enzymes and creatinine. Overall, this new drug delivery system formulation shows promise for cancer treatment and deserves to be further studied in the future.
Abbas Rahdar; Mohammad Reza Hajinezhad; Mahmood Barani; Saman Sargazi; Maryam Zaboli; Esraa Ghazy; Francesco Baino; Magali Cucchiarini; Muhammad Bilal; Sadanand Pandey. Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations. Journal of Molecular Liquids 2021, 117028 .
AMA StyleAbbas Rahdar, Mohammad Reza Hajinezhad, Mahmood Barani, Saman Sargazi, Maryam Zaboli, Esraa Ghazy, Francesco Baino, Magali Cucchiarini, Muhammad Bilal, Sadanand Pandey. Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations. Journal of Molecular Liquids. 2021; ():117028.
Chicago/Turabian StyleAbbas Rahdar; Mohammad Reza Hajinezhad; Mahmood Barani; Saman Sargazi; Maryam Zaboli; Esraa Ghazy; Francesco Baino; Magali Cucchiarini; Muhammad Bilal; Sadanand Pandey. 2021. "Pluronic F127/Doxorubicin microemulsions: Preparation, characterization, and toxicity evaluations." Journal of Molecular Liquids , no. : 117028.
The threat of the accumulation of heavy metals in wastewater is increasing, due to their abilities to inflict damage to human health, especially in the past decade. The world’s environmental agencies are trying to issue several regulations that allow the management and control of random disposals of heavy metals. Scientific studies have heavily focused on finding suitable materials and techniques for the purification of wastewaters, but most solutions have been rejected due to cost-related issues. Several potential materials for this objective have been found and have been compared to determine the most suitable material for the purification process. Sawdust, among all the materials investigated, shows high potential and very promising results. Sawdust has been shown to have a good structure suitable for water purification processes. Parameters affecting the adsorption mechanism of heavy metals into sawdust have been studied and it has been shown that pH, contact time and several other parameters could play a major role in improving the adsorption process. The adsorption was found to follow the Langmuir or Freundlich isotherm and a pseudo second-order kinetic model, meaning that the type of adsorption was a chemisorption. Sawdust has major advantages to be considered and is one of the most promising materials to solve the wastewater problem.
Elie Meez; Abbas Rahdar; George Kyzas. Sawdust for the Removal of Heavy Metals from Water: A Review. Molecules 2021, 26, 4318 .
AMA StyleElie Meez, Abbas Rahdar, George Kyzas. Sawdust for the Removal of Heavy Metals from Water: A Review. Molecules. 2021; 26 (14):4318.
Chicago/Turabian StyleElie Meez; Abbas Rahdar; George Kyzas. 2021. "Sawdust for the Removal of Heavy Metals from Water: A Review." Molecules 26, no. 14: 4318.
We have demonstrated the enhanced in vivo oral efficacy and enhanced hepatoprotective effects of preactivated thiolated chitosan (Cht) nanoparticles (NPs) for tuberculosis. The mannose anchored preactivated thiolated chitosan nanoparticles (MPTCht-NPs) were prepared and characterized in terms of their particle size, in vitro entrapment efficiency (EE%) and zeta potential (mV). NPs were also evaluated in terms of mucoadhesion, % hemolysis, permeation enhancement, in vivo pharmacokinetics, toxicity and immunomodulation. NPs exhibited an average particle size of 307 nm with 19 folds enhanced permeation in comparison to conventional Rifampicin (Rif) formulation across everted rat intestine. The evaluation of in vivo pharmacokinetic parameters indicated 16 folds improvement in oral bioavailability in comparison to Rif alone following oral administration in rabbits. There was significant difference in the levels of serum transaminases, oxidative stress markers, and expression levels of anti-apoptotic (Bcl-2) and pro-apoptotic (Bax) genes between Rif treated and NPs treated groups. The serum transaminases levels were normal with MPTCht-NPs treated groups as compared to Rif treated groups while the levels of glutathione were markedly increased in MPTCht-NPs treated group. Furthermore, the levels of Bax were enhanced with the MPTCht-NPs treatment. In summary, these findings revealed that the designed NPs may act as promising therapeutic strategy against tuberculosis in a dose-dependent manner while providing the immunomodulation and hepatoprotective effect.
Aisha Rauf; Tanveer A. Tabish; Ibrahim M Ibrahim; Muhammad Rauf Ul Hassan; Sabira Tahseen; Mansoor Abdullah Sandhu; Gul Shahnaz; Abbas Rahdar; Magali Cucchiarini; Sadanand Pandey. Design of Mannose-Coated Rifampicin Nanoparticles Modulating the Immune Response and Rifampicin Induced Hepatotoxicity with Improved Oral Drug Delivery. Arabian Journal of Chemistry 2021, 103321 .
AMA StyleAisha Rauf, Tanveer A. Tabish, Ibrahim M Ibrahim, Muhammad Rauf Ul Hassan, Sabira Tahseen, Mansoor Abdullah Sandhu, Gul Shahnaz, Abbas Rahdar, Magali Cucchiarini, Sadanand Pandey. Design of Mannose-Coated Rifampicin Nanoparticles Modulating the Immune Response and Rifampicin Induced Hepatotoxicity with Improved Oral Drug Delivery. Arabian Journal of Chemistry. 2021; ():103321.
Chicago/Turabian StyleAisha Rauf; Tanveer A. Tabish; Ibrahim M Ibrahim; Muhammad Rauf Ul Hassan; Sabira Tahseen; Mansoor Abdullah Sandhu; Gul Shahnaz; Abbas Rahdar; Magali Cucchiarini; Sadanand Pandey. 2021. "Design of Mannose-Coated Rifampicin Nanoparticles Modulating the Immune Response and Rifampicin Induced Hepatotoxicity with Improved Oral Drug Delivery." Arabian Journal of Chemistry , no. : 103321.
The rapid development of multidrug co-delivery and nano-medicines has made spontaneous progress in tumor treatment and diagnosis. DNA is a unique biological molecule that can be tailored and molded into various nanostructures. The addition of ligands or stimuli-responsive elements enables DNA nanostructures to mediate highly targeted drug delivery to the cancer cells. Smart DNA nanostructures, owing to their various shapes, sizes, geometry, sequences, and characteristics, have various modes of cellular internalization and final disposition. On the other hand, functionalized DNA nanocarriers have specific receptor-mediated uptake, and most of these ligand anchored nanostructures able to escape lysosomal degradation. DNA-based and stimuli responsive nano-carrier systems are the latest advancement in cancer targeting. The data exploration from various studies demonstrated that the DNA nanostructure and stimuli responsive drug delivery systems are perfect tools to overcome the problems existing in the cancer treatment including toxicity and compromised drug efficacy. In this light, the review summarized the insights about various types of DNA nanostructures and stimuli responsive nanocarrier systems applications for diagnosis and treatment of cancer.
Fakhara Sabir; Mahira Zeeshan; Ushna Laraib; Mahmood Barani; Abbas Rahdar; Magali Cucchiarini; Sadanand Pandey. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. Cancers 2021, 13, 3396 .
AMA StyleFakhara Sabir, Mahira Zeeshan, Ushna Laraib, Mahmood Barani, Abbas Rahdar, Magali Cucchiarini, Sadanand Pandey. DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges. Cancers. 2021; 13 (14):3396.
Chicago/Turabian StyleFakhara Sabir; Mahira Zeeshan; Ushna Laraib; Mahmood Barani; Abbas Rahdar; Magali Cucchiarini; Sadanand Pandey. 2021. "DNA Based and Stimuli-Responsive Smart Nanocarrier for Diagnosis and Treatment of Cancer: Applications and Challenges." Cancers 13, no. 14: 3396.
Head and neck cancer (HNC) is a category of cancers that typically arise from the nose-, mouth-, and throat-lining squamous cells. The later stage of HNC diagnosis significantly affects the patient’s survival rate. This makes it mandatory to diagnose this cancer with a suitable biomarker and imaging techniques at the earlier stages of growth. There are limitations to traditional technologies for early detection of HNC. Furthermore, the use of nanocarriers for delivering chemo-, radio-, and phototherapeutic drugs represents a promising approach for improving the outcome of HNC treatments. Several studies with nanostructures focus on the development of a targeted and sustained release of anticancer molecules with reduced side effects. Besides, nanovehicles could allow co-delivering of anticancer drugs for synergistic activity to counteract chemo- or radioresistance. Additionally, a new generation of smart nanomaterials with stimuli-responsive properties have been developed to distinguish between unique tumor conditions and healthy tissue. In this light, the present article reviews the mechanisms used by different nanostructures (metallic and metal oxide nanoparticles, polymeric nanoparticles, quantum dots, liposomes, nanomicelles, etc.) to improve cancer diagnosis and treatment, provides an up-to-date picture of the state of the art in this field, and highlights the major challenges for future improvements.
Gustavo Ruiz-Pulido; Dora Medina; Mahmood Barani; Abbas Rahdar; Ghasem Sargazi; Francesco Baino; Sadanand Pandey. Nanomaterials for the Diagnosis and Treatment of Head and Neck Cancers: A Review. Materials 2021, 14, 3706 .
AMA StyleGustavo Ruiz-Pulido, Dora Medina, Mahmood Barani, Abbas Rahdar, Ghasem Sargazi, Francesco Baino, Sadanand Pandey. Nanomaterials for the Diagnosis and Treatment of Head and Neck Cancers: A Review. Materials. 2021; 14 (13):3706.
Chicago/Turabian StyleGustavo Ruiz-Pulido; Dora Medina; Mahmood Barani; Abbas Rahdar; Ghasem Sargazi; Francesco Baino; Sadanand Pandey. 2021. "Nanomaterials for the Diagnosis and Treatment of Head and Neck Cancers: A Review." Materials 14, no. 13: 3706.
The polyol method has been used to synthesize CoNiFe and CoNiZn alloy nanoparticles (NPs). The magnetic characteristics of the products have been measured by vibration sample magnetometry (VSM) analysis. At the same time, the microstructure and morphology were inspected by X-ray diffraction (XRD) and scanning electron microscopy (SEM), respectively. Magnetic measurement of samples by the VSM indicated that samples have soft ferromagnetic behavior. Spherical-shaped grains for samples were confirmed by the SEM. MTT (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and lactate dehydrogenase (LDH) assays were used to determine the cytotoxic effects of the synthesized NPs. Cytotoxic evaluations showed that treatment with 25 to 400 µg/mL of CoNiZn and CoNiFe NPs exerted a significant time- and concentration-dependent toxicity in MCF7 and HUVEC cells and markedly enhanced the LDH leakage after 48 h of exposure (p< 0.05 compared with untreated cells). Furthermore, NPs with concentrations higher than 12.5 µg/mL induced evident morphological changes in the studied cell lines. Treatment with 12.5 µg/mL of CoNiZn and CoNiFe NPs was safe and did not affect normal human cell survival. The results of in vitro cytotoxicity assessments show promise in supporting the suitability of the synthesized NPs to build high-performance theranostic nanoplatforms for simultaneous cancer imaging and therapy without affecting normal human cells.
Sima Alikhanzadeh-Arani; Mohammad Almasi-Kashi; Saman Sargazi; Abbas Rahdar; Rabia Arshad; Francesco Baino. CoNiZn and CoNiFe Nanoparticles: Synthesis, Physical Characterization, and In Vitro Cytotoxicity Evaluations. Applied Sciences 2021, 11, 5339 .
AMA StyleSima Alikhanzadeh-Arani, Mohammad Almasi-Kashi, Saman Sargazi, Abbas Rahdar, Rabia Arshad, Francesco Baino. CoNiZn and CoNiFe Nanoparticles: Synthesis, Physical Characterization, and In Vitro Cytotoxicity Evaluations. Applied Sciences. 2021; 11 (12):5339.
Chicago/Turabian StyleSima Alikhanzadeh-Arani; Mohammad Almasi-Kashi; Saman Sargazi; Abbas Rahdar; Rabia Arshad; Francesco Baino. 2021. "CoNiZn and CoNiFe Nanoparticles: Synthesis, Physical Characterization, and In Vitro Cytotoxicity Evaluations." Applied Sciences 11, no. 12: 5339.
Valproic acid (VPA), an anti-epileptic drug used to treat seizures, epilepsy, and psychological disorders, has shown promising antitumor potential; however, the side effects are a serious concern. This effort reports the nano-formulation and characterization of oil-in-water F127/lignin microemulsions to enhance the bioavailability of valproic acid (VPA). Microemulsions showed a high encapsulation efficiency and prolonged release. F127/VPA and lignin/VPA microemulsions were tested for their cytotoxic activity via MTT colorimetric assay and LDH leakage assay in cancerous (MCF7 and Hela) and normal (HUVEC) cell lines. High encapsulation efficiency and sustained release were observed for F127/VPA microemulsions. Cell proliferation assays showed that VPA microemulsions induced evident morphological alterations and were more effective than the free drug in inhibiting the growth of cancer cells. In contrast, normal cells seem to be less affected by these formulations. Moreover, F127/VPA microemulsions significantly increased caspase-3 activity in Hela cells (P<0.05). In vivo administration of free VPA at the dose of 20 mg/kg significantly increased serum biochemical parameters and liver lipid peroxidation in rats compared to the control rats. In addition, the 20 mg/kg of free VPA significantly increased liver lipid peroxidation. The group treated with the 20 mg/kg dose of F127/VPA microemulsions showed increased toxicity compared to the group treated with lignin/VPA microemulsions and free VPA. Molecular simulations revealed that the formation of seven and six-member rings via HB interactions between VPA and F127 influence the stability of the corresponding microemulsion systems and may help to a better action of F127/VPA in comparison to free VPA. Together, our experimental and theoretical findings highlight the opportunity to exploit surfactant microemulsion systems for efficient VPA delivery to target progressive cancer cells and prevent undesirable toxicity leading to tissue injuries.
Saman Sargazi; Mohammad Reza Hajinezhad; Mahmood Barani; Abbas Rahdar; Sheida Shahraki; Pouya Karimi; Magali Cucchiarini; Mehrdad Khatami; Sadanand Pandey. Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid. Journal of Molecular Liquids 2021, 338, 116625 .
AMA StyleSaman Sargazi, Mohammad Reza Hajinezhad, Mahmood Barani, Abbas Rahdar, Sheida Shahraki, Pouya Karimi, Magali Cucchiarini, Mehrdad Khatami, Sadanand Pandey. Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid. Journal of Molecular Liquids. 2021; 338 ():116625.
Chicago/Turabian StyleSaman Sargazi; Mohammad Reza Hajinezhad; Mahmood Barani; Abbas Rahdar; Sheida Shahraki; Pouya Karimi; Magali Cucchiarini; Mehrdad Khatami; Sadanand Pandey. 2021. "Synthesis, characterization, toxicity and morphology assessments of newly prepared microemulsion systems for delivery of valproic acid." Journal of Molecular Liquids 338, no. : 116625.
In this study, the biosynthesis of zinc oxide nanoparticles using Aspergillus niger (A/ZnO-NPs) is described. These particles have been characterized by UV–Vis spectrum analysis, X-ray powder diffraction, field emission scanning electron microscopy, and transmission electron microscopy. To use this biosynthesized nanoparticle as an antiproliferative and antimicrobial agent, the IC50 value against the breast cancer cell line and inhibition zone against Escherichia coli were used to optimize the effect of two processing factors including dose of filtrate fungi cell and temperature. The biosynthesized A/ZnO-NPs had an absorbance band at 320 nm and spherical shapes. The mean particles size was 35 nm. RSM (response surface methodology) was utilized to investigate the outcome responses. The Model F-value of 12.21 and 7.29 implies that the model was significant for both responses. The contour plot against inhibition zone for temperature and dose showed that if the dose increases from 3.8 to 17.2 µg/mL, the inhibition zone increases up to 35 mm. As an alternative to chemical and/or physical methods, biosynthesizing zinc oxide NPs through fungi extracts can serve as a more facile and eco-friendly strategy. Additionally, for optimization of the processes, the outcome responses in the biomedical available test can be used in the synthesis of ZnO-NPs that are utilized for large-scale production in various medical applications.
Ali Es-Haghi; Mohammad Taghavizadeh Yazdi; Mohammad Sharifalhoseini; Mohsen Baghani; Ehsan Yousefi; Abbas Rahdar; Francesco Baino. Application of Response Surface Methodology for Optimizing the Therapeutic Activity of ZnO Nanoparticles Biosynthesized from Aspergillus niger. Biomimetics 2021, 6, 34 .
AMA StyleAli Es-Haghi, Mohammad Taghavizadeh Yazdi, Mohammad Sharifalhoseini, Mohsen Baghani, Ehsan Yousefi, Abbas Rahdar, Francesco Baino. Application of Response Surface Methodology for Optimizing the Therapeutic Activity of ZnO Nanoparticles Biosynthesized from Aspergillus niger. Biomimetics. 2021; 6 (2):34.
Chicago/Turabian StyleAli Es-Haghi; Mohammad Taghavizadeh Yazdi; Mohammad Sharifalhoseini; Mohsen Baghani; Ehsan Yousefi; Abbas Rahdar; Francesco Baino. 2021. "Application of Response Surface Methodology for Optimizing the Therapeutic Activity of ZnO Nanoparticles Biosynthesized from Aspergillus niger." Biomimetics 6, no. 2: 34.
Single-nucleotide polymorphisms (SNPs) are the simplest and most common type of DNA variations in the human genome. This class of attractive genetic markers, along with point mutations, have been associated with the risk of developing a wide range of diseases, including cancer, cardiovascular diseases, autoimmune diseases, and neurodegenerative diseases. Several existing methods to detect SNPs and mutations in body fluids have faced limitations. Therefore, there is a need to focus on developing noninvasive future polymerase chain reaction (PCR)–free tools to detect low-abundant SNPs in such specimens. The detection of small concentrations of SNPs in the presence of a large background of wild-type genes is the biggest hurdle. Hence, the screening and detection of SNPs need efficient and straightforward strategies. Suitable amplification methods are being explored to avoid high-throughput settings and laborious efforts. Therefore, currently, DNA sensing methods are being explored for the ultrasensitive detection of SNPs based on the concept of nanotechnology. Owing to their small size and improved surface area, nanomaterials hold the extensive capacity to be used as biosensors in the genotyping and highly sensitive recognition of single-base mismatch in the presence of incomparable wild-type DNA fragments. Different nanomaterials have been combined with imaging and sensing techniques and amplification methods to facilitate the less time-consuming and easy detection of SNPs in different diseases. This review aims to highlight some of the most recent findings on the aspects of nanotechnology-based SNP sensing methods used for the specific and ultrasensitive detection of low-concentration SNPs and rare mutations.
Mahwash Mukhtar; Saman Sargazi; Mahmood Barani; Henning Madry; Abbas Rahdar; Magali Cucchiarini. Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review. Nanomaterials 2021, 11, 1384 .
AMA StyleMahwash Mukhtar, Saman Sargazi, Mahmood Barani, Henning Madry, Abbas Rahdar, Magali Cucchiarini. Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review. Nanomaterials. 2021; 11 (6):1384.
Chicago/Turabian StyleMahwash Mukhtar; Saman Sargazi; Mahmood Barani; Henning Madry; Abbas Rahdar; Magali Cucchiarini. 2021. "Application of Nanotechnology for Sensitive Detection of Low-Abundance Single-Nucleotide Variations in Genomic DNA: A Review." Nanomaterials 11, no. 6: 1384.
Bismuth-based nanocomposites (BiNCs) have considered as interesting materials for applications in the fields of electrochemistry and optoelectronics, among others, due to their structural flexibility, high stability and facile manufacturing process. Their unique photo-oxidation properties are of particular interest in water splitting and pollutant degradation. The present review concern on the recent advances in architecting and morphology engineering bismuth-based heterojunction nanocomposites including bismuth-vanadate (BiVO4), bismuth-tungstate (Bi2WO6), bismuth-molybdate (Bi2MoO6), and bismuth-chalcogenides (Bi2A3; A = O, S, Se, Te), leading to enhanced efficiency of bismuthal nanocomposites through heterojunction assembly. As higher proficiency encourages environmental friendlier production, sustainable nanocomposites production approaches are highly needed in the scope of the circular economy paradigms. Thus, co-precipitation method and hydrothermal synthesis are discussed in detail due to their size selectivity, morphological variability, and reliability. This study paves the way toward the synthesis of more effective bismuthal nanocomposites with lower environmental impact. In addition, pollutants and biological components sensing capabilities of carbon, graphene and biopolymer-based BiNCs are discussed, signifying their role in environmental monitoring of heavy metals. Thus, the present review highlights the production of improved nanocomposites for photocatalysis and heavy metal sensors which are cost effective, reliable, reusable and efficient.
Maria Batool; Muhammad Faizan Nazar; Aneesa Awan; Muhammad Bilal Tahir; Abbas Rahdar; Ahmed Esmail Shalan; Senentxu Lanceros-Méndez; Muhammad Nadeem Zafar. Bismuth-based heterojunction nanocomposites for photocatalysis and heavy metal detection applications. Nano-Structures & Nano-Objects 2021, 27, 100762 .
AMA StyleMaria Batool, Muhammad Faizan Nazar, Aneesa Awan, Muhammad Bilal Tahir, Abbas Rahdar, Ahmed Esmail Shalan, Senentxu Lanceros-Méndez, Muhammad Nadeem Zafar. Bismuth-based heterojunction nanocomposites for photocatalysis and heavy metal detection applications. Nano-Structures & Nano-Objects. 2021; 27 ():100762.
Chicago/Turabian StyleMaria Batool; Muhammad Faizan Nazar; Aneesa Awan; Muhammad Bilal Tahir; Abbas Rahdar; Ahmed Esmail Shalan; Senentxu Lanceros-Méndez; Muhammad Nadeem Zafar. 2021. "Bismuth-based heterojunction nanocomposites for photocatalysis and heavy metal detection applications." Nano-Structures & Nano-Objects 27, no. : 100762.
Bladder cancer (BC) is the second most common cancer of the urinary tract in men and the fourth most common cancer in women, and its incidence rises with age. There are many conventional methods for diagnosis and treatment of BC. There are some current biomarkers and clinical tests for the diagnosis and treatment of BC. For example, radiotherapy combined with chemotherapy and surgical, but residual tumor cells mostly cause tumor recurrence. In addition, chemotherapy after transurethral resection causes high side effects, and lack of selectivity, and low sensitivity in sensing. Therefore, it is essential to improve new procedures for the diagnosis and treatment of BC. Nanotechnology has recently sparked an interest in a variety of areas, including medicine, chemistry, physics, and biology. Nanoparticles (NP) have been used in tumor therapies as appropriate tools for enhancing drug delivery efficacy and enabling therapeutic performance. It is noteworthy, nanomaterial could be reduced the limitation of conventional cancer diagnosis and treatments. Since, the major disadvantages of therapeutic drugs are their insolubility in an aqueous solvent, for instance, paclitaxel (PTX) is one of the important therapeutic agents utilized to treating BC, due to its ability to prevent cancer cell growth. However, its major problem is the poor solubility, which has confirmed to be a challenge when improving stable formulations for BC treatment. In order to reduce this challenge, anti-cancer drugs can be loaded into NPs that can improve water solubility. In our review, we state several nanosystem, which can effective and useful for the diagnosis, treatment of BC. We investigate the function of metal NPs, polymeric NPs, liposomes, and exosomes accompanied therapeutic agents for BC Therapy, and then focused on the potential of nanotechnology to improve conventional approaches in sensing.
Mahmood Barani; Seyedeh Hosseinikhah; Abbas Rahdar; Leila Farhoudi; Rabia Arshad; Magali Cucchiarini; Sadanand Pandey. Nanotechnology in Bladder Cancer: Diagnosis and Treatment. Cancers 2021, 13, 2214 .
AMA StyleMahmood Barani, Seyedeh Hosseinikhah, Abbas Rahdar, Leila Farhoudi, Rabia Arshad, Magali Cucchiarini, Sadanand Pandey. Nanotechnology in Bladder Cancer: Diagnosis and Treatment. Cancers. 2021; 13 (9):2214.
Chicago/Turabian StyleMahmood Barani; Seyedeh Hosseinikhah; Abbas Rahdar; Leila Farhoudi; Rabia Arshad; Magali Cucchiarini; Sadanand Pandey. 2021. "Nanotechnology in Bladder Cancer: Diagnosis and Treatment." Cancers 13, no. 9: 2214.
Ciprofloxacin (CIP), a potent anti-bacterial agent of the fluroquinolone family, shows poor solubility and permeability, thus leading to the development of intracellular pathogens induced multi-drug resistance and biofilms formation. To synergistically improve the biopharmaceutical parameters of CIP, a hyaluronic acid (FDA approved biocompatible polymer) functionalized self-nano emulsifying drug delivery system (HA-CIP-SNEDDS) was designed in the present study. SNEDDS formulations were tested via solubility, droplet size, zeta potential, a polydispersity index, thermodynamic stability, surface morphology, solid-state characterization, drug loading/release, cellular uptake, and biocompatibility. The final (HA-CIP-SNEDDS) formulation exhibited a mean droplet size of 50 nm with the 0.3 poly dispersity index and negative zeta potential (−11.4 mV). HA-based SNEDDS containing CIP showed an improved ability to permeate goat intestinal mucus. After 4 h, CIP-SNEDDS showed a 2-fold and HA-CIP-SNEDDS showed a 4-fold permeation enhancement as compared to the free CIP. Moreover, 80% drug release of HA-CIP-SNEDDS was demonstrated to be superior and sustained for 72 h in comparison to free CIP. However, anti-biofilm activity of HA-CIP-SNEDDS against Salmonella typhi was higher than CIP-SNEDDS and free CIP. HA-CIP-SNEDDS exhibited increased biocompatibility and improved oral pharmacokinetics as compared to free CIP. Taken together, HA-CIP-SNEDDS formulation seems to be a promising agent against Salmonella typhi with a strong targeting potential.
Rabia Arshad; Tanveer Tabish; Maria Kiani; Ibrahim Ibrahim; Gul Shahnaz; Abbas Rahdar; Misook Kang; Sadanand Pandey. A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection. Nanomaterials 2021, 11, 1086 .
AMA StyleRabia Arshad, Tanveer Tabish, Maria Kiani, Ibrahim Ibrahim, Gul Shahnaz, Abbas Rahdar, Misook Kang, Sadanand Pandey. A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection. Nanomaterials. 2021; 11 (5):1086.
Chicago/Turabian StyleRabia Arshad; Tanveer Tabish; Maria Kiani; Ibrahim Ibrahim; Gul Shahnaz; Abbas Rahdar; Misook Kang; Sadanand Pandey. 2021. "A Hyaluronic Acid Functionalized Self-Nano-Emulsifying Drug Delivery System (SNEDDS) for Enhancement in Ciprofloxacin Targeted Delivery against Intracellular Infection." Nanomaterials 11, no. 5: 1086.
Dyes are known as one of the most dangerous industrial pollutants which can cause skin diseases, allergy, and provoke cancer and mutation in humans. Therefore, one of the important environmental issues is the effective removal of dyes from industrial wastewater. In the current work, BaFe12O19/[email protected] glycol (abbreviated as BFO/[email protected]) nanocomposite was synthesized and evaluated regarding its capacity for adsorptive removal of a model dye Acid Blue 92 (denoted as AB92) from aqueous solutions. The characteristics of the prepared nanocomposite was determined by tests such as X-ray diffraction (XRD), scanning electron microscope (SEM), vibration sample magnetization (VSM), and Fourier transform infrared spectroscopy (FTIR). The effects of conditional parameters including pH (2–12), initial concentration of dye (20–100 mg/L), adsorbent dosage (0.02–0.1 g/L) and contact time (0-180 min) on the adsorption of dye were investigated and then optimized. The results indicated that with the increase of the adsorbent dosage from 0.02 to 0.1 g/L, the removal efficiency increased from 74.1% to 78.6%, and the adsorbed amount decreased from 148.25 to 31.44 mg/g. The maximum removal efficiency (77.54%) and adsorption capacity (31.02 mg/g) were observed at pH 2. Therefore, the general optimization conditions revealed that the maximum adsorption efficiency of dye was obtained in condition of initial concentration of 20 mg/L, contact time of 1 h and pH of solution equal 2. The adsorption isotherm and kinetic data were evaluated using a series of models. The pseudo-second order kinetic model and Freundlich isotherm model show the best fitting with experimental data with R2∼0.999.
Somayeh Rahdar; Abbas Rahdar; Mostafa Sattari; Laleh Hafshejani; Athanasia Tolkou; George Kyzas. Barium/[email protected] Glycol Nanocomposites for Dye Removal from Aqueous Solutions. Polymers 2021, 13, 1161 .
AMA StyleSomayeh Rahdar, Abbas Rahdar, Mostafa Sattari, Laleh Hafshejani, Athanasia Tolkou, George Kyzas. Barium/[email protected] Glycol Nanocomposites for Dye Removal from Aqueous Solutions. Polymers. 2021; 13 (7):1161.
Chicago/Turabian StyleSomayeh Rahdar; Abbas Rahdar; Mostafa Sattari; Laleh Hafshejani; Athanasia Tolkou; George Kyzas. 2021. "Barium/[email protected] Glycol Nanocomposites for Dye Removal from Aqueous Solutions." Polymers 13, no. 7: 1161.
Lung cancer is among the most prevalent and leading causes of death worldwide. The major reason for high mortality is the late diagnosis of the disease, and in most cases, lung cancer is diagnosed at fourth stage in which the cancer has metastasized to almost all vital organs. The other reason for higher mortality is the uptake of the chemotherapeutic agents by the healthy cells, which in turn increases the chances of cytotoxicity to the healthy body cells. The complex pathophysiology of lung cancer provides various pathways to target the cancerous cells. In this regard, upregulated onco-receptors on the cell surface of tumor including epidermal growth factor receptor (EGFR), integrins, transferrin receptor (TFR), folate receptor (FR), cluster of differentiation 44 (CD44) receptor, etc. could be exploited for the inhibition of pathways and tumor-specific drug targeting. Further, cancer borne immunological targets like T-lymphocytes, myeloid-derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and dendritic cells could serve as a target site to modulate tumor activity through targeting various surface-expressed receptors or interfering with immune cell-specific pathways. Hence, novel approaches are required for both the diagnosis and treatment of lung cancers. In this context, several researchers have employed various targeted delivery approaches to overcome the problems allied with the conventional diagnosis of and therapy methods used against lung cancer. Nanoparticles are cell nonspecific in biological systems, and may cause unwanted deleterious effects in the body. Therefore, nanodrug delivery systems (NDDSs) need further advancement to overcome the problem of toxicity in the treatment of lung cancer. Moreover, the route of nanomedicines’ delivery to lungs plays a vital role in localizing the drug concentration to target the lung cancer. Surface-modified nanoparticles and hybrid nanoparticles have a wide range of applications in the field of theranostics. This cross-disciplinary review summarizes the current knowledge of the pathways implicated in the different classes of lung cancer with an emphasis on the clinical implications of the increasing number of actionable molecular targets. Furthermore, it focuses specifically on the significance and emerging role of surface functionalized and hybrid nanomaterials as drug delivery systems through citing recent examples targeted at lung cancer treatment.
Fakhara Sabir; Maimoona Qindeel; Mahira Zeeshan; Qurrat Ul Ain; Abbas Rahdar; Mahmood Barani; Edurne González; M. Aboudzadeh. Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review. Processes 2021, 9, 621 .
AMA StyleFakhara Sabir, Maimoona Qindeel, Mahira Zeeshan, Qurrat Ul Ain, Abbas Rahdar, Mahmood Barani, Edurne González, M. Aboudzadeh. Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review. Processes. 2021; 9 (4):621.
Chicago/Turabian StyleFakhara Sabir; Maimoona Qindeel; Mahira Zeeshan; Qurrat Ul Ain; Abbas Rahdar; Mahmood Barani; Edurne González; M. Aboudzadeh. 2021. "Onco-Receptors Targeting in Lung Cancer via Application of Surface-Modified and Hybrid Nanoparticles: A Cross-Disciplinary Review." Processes 9, no. 4: 621.
Cardiovascular diseases (CVDs) are the world’s leading cause of mortality and represent a large contributor to the costs of medical care. Although tremendous progress has been made for the diagnosis of CVDs, there is an important need for more effective early diagnosis and the design of novel diagnostic methods. The diagnosis of CVDs generally relies on signs and symptoms depending on molecular imaging (MI) or on CVD-associated biomarkers. For early-stage CVDs, however, the reliability, specificity, and accuracy of the analysis is still problematic. Because of their unique chemical and physical properties, nanomaterial systems have been recognized as potential candidates to enhance the functional use of diagnostic instruments. Nanomaterials such as gold nanoparticles, carbon nanotubes, quantum dots, lipids, and polymeric nanoparticles represent novel sources to target CVDs. The special properties of nanomaterials including surface energy and topographies actively enhance the cellular response within CVDs. The availability of newly advanced techniques in nanomaterial science opens new avenues for the targeting of CVDs. The successful application of nanomaterials for CVDs needs a detailed understanding of both the disease and targeting moieties.
Fakhara Sabir; Mahmood Barani; Mahwash Mukhtar; Abbas Rahdar; Magali Cucchiarini; Muhammad Zafar; Tapan Behl; Simona Bungau. Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview. Chemosensors 2021, 9, 67 .
AMA StyleFakhara Sabir, Mahmood Barani, Mahwash Mukhtar, Abbas Rahdar, Magali Cucchiarini, Muhammad Zafar, Tapan Behl, Simona Bungau. Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview. Chemosensors. 2021; 9 (4):67.
Chicago/Turabian StyleFakhara Sabir; Mahmood Barani; Mahwash Mukhtar; Abbas Rahdar; Magali Cucchiarini; Muhammad Zafar; Tapan Behl; Simona Bungau. 2021. "Nanodiagnosis and Nanotreatment of Cardiovascular Diseases: An Overview." Chemosensors 9, no. 4: 67.
The development of effective strategies for local administration of chemotherapeutic drugs, thus minimizing the adverse side effects to patients, is one of the key challenges in biomedicine and cancer research. This work reports the formulation and characterization of PluronicF127 microemulsions to enhance the bioavailability of Cisplatin (Cis). The size of Cis microemulsion was about 12.0 nm, as assessed by dynamic light scattering analysis. In vitro cytotoxic activity of free Cis and F127/Cis microemulsions were studied on malignant (C152 and MCF7) and normal (HUVEC) cells via tetrazolium (MTT) colorimetric assay. Cell morphology was also monitored. In vitro assessments revealed thatF127/Cis microemulsions induced cytotoxicity/morphological changes to a lesser extent than free Cis. Regarding in vivo experiments, F127/Cis microemulsions were injected intraperitoneally at 7 and 14 mg/kg doses into adult male Wistar rats to assess histologic and biochemical changes. In this case, the bulk Cis group caused severe histopathological changes and significant increases in serum liver enzymes and serum kidney function markers. The group treated with the 14 mg/kg dose of F127/Cis microemulsions also showed severe fatty changes and significant increases in serum liver enzymes, blood urea nitrogen, and creatinine levels. The group treated with the low dose of nano-Cis showed a significant increase in serum liver enzymes levels accompanied by mild fatty changes of the liver. Theoretical surveys were performed to get an understanding of the interplay between F127 and Cis. Results reveal that hydrogen bonding (HB) interactions with F127have an influence on the molecular properties of Cis and may playa role in the lower toxicity of F127/Cis in comparison to free Cis.
Saman Sargazi; Mohammad Hajinezhad; Mahmood Barani; Mahwash Mukhtar; Abbas Rahdar; Francesco Baino; Pouya Karimi; Sadanand Pandey. F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies. Applied Sciences 2021, 11, 3006 .
AMA StyleSaman Sargazi, Mohammad Hajinezhad, Mahmood Barani, Mahwash Mukhtar, Abbas Rahdar, Francesco Baino, Pouya Karimi, Sadanand Pandey. F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies. Applied Sciences. 2021; 11 (7):3006.
Chicago/Turabian StyleSaman Sargazi; Mohammad Hajinezhad; Mahmood Barani; Mahwash Mukhtar; Abbas Rahdar; Francesco Baino; Pouya Karimi; Sadanand Pandey. 2021. "F127/Cisplatin Microemulsions: In Vitro, In Vivo and Computational Studies." Applied Sciences 11, no. 7: 3006.
Quercetin (Q) is formulated into oil-in-water F127 microemulsions to improve its bioavailability. The size of the Q-loaded microemulsions system was about 8 nm by dynamic light scattering analysis. To compare antioxidant activity of bulk solution and microemulsion of Q, free radical scavenging activity was evaluated against 2,2-diphenyl-1-picrylhydrazyl (DPPH). The IC50 values were 56.77 and 187.68 μM, respectively. The drug in the bulk form released 16.34 times faster than microemulsion form. Although gentamicin (GM) has potent efficacy against gram-negative bacteria, it induces renal toxicity. Poor solubility and low bioavailability of Q as a bioflavonoid with potent antioxidant activity, limit its therapeutic application. We aimed to compare the effect of free Q and nanoencapsulated (NEQ) against GM-induced renal damage in Wistar rats. Forty-two animals were divided into six groups. Control and GM groups received apo-nanomicelles and GM (100 mg/kg) for 10 days. Two groups received Q (50 mg/kg, i.g.) and NEQ (50 mg/kg, i.g.) respectively for 10 days. Remaining two groups received Q and NEQ (50 mg/kg, i.g.) plus GM (100 mg/kg, i.p.) simultaneously for 10 days. After the experiments, serum and kidneys were used for biochemical, molecular and histological examinations. Immunohistochemical analysis was performed to explore kidney injury molecule-1 (KIM-1) expression as a specific protein biomarker of renal injury. Our findings indicated oxidative stress and altered histological features in renal tissue with deviated serum renal biomarkers in GM-treated rats. Although Q treatment in GM group tried to protect against GM-induced nephrotoxicity, but there were still differences compared to control rats. However, NEQ administration corrected elevations in the levels of urea, creatinine, uric acid and decrements in serum total proteins of GM group. Meanwhile, NEQ restored renal oxidative injury in GM rats through attenuation of lipid peroxidation and enhancement of antioxidant defense systems, glutathione, catalase and superoxide dismutase. NEQ could also normalize GM-induced abnormal renal histology features including fibrosis. Furthermore, the result of immunohistochemistry study confirmed these findings by undetecting KIM-1 expression in NEQ treated GM group, meanwhile showing this renal biomarker in GM and Q treated GM groups. Therefore, NEQ seems to be useful in protecting against renal oxidative stress and kidney damage in a rat model of GM nephrotoxicity which deserve further evaluations.
Abbas Rahdar; Parisa Hasanein; Muhammad Bilal; Hamid Beyzaei; George Z. Kyzas. Quercetin-loaded F127 nanomicelles: Antioxidant activity and protection against renal injury induced by gentamicin in rats. Life Sciences 2021, 276, 119420 .
AMA StyleAbbas Rahdar, Parisa Hasanein, Muhammad Bilal, Hamid Beyzaei, George Z. Kyzas. Quercetin-loaded F127 nanomicelles: Antioxidant activity and protection against renal injury induced by gentamicin in rats. Life Sciences. 2021; 276 ():119420.
Chicago/Turabian StyleAbbas Rahdar; Parisa Hasanein; Muhammad Bilal; Hamid Beyzaei; George Z. Kyzas. 2021. "Quercetin-loaded F127 nanomicelles: Antioxidant activity and protection against renal injury induced by gentamicin in rats." Life Sciences 276, no. : 119420.
Retinoblastoma is a rare type of cancer, and its treatment, as well as diagnosis, is challenging, owing to mutations in the tumor-suppressor genes and lack of targeted, efficient, cost-effective therapy, exhibiting a significant need for novel approaches to address these concerns. For this purpose, nanotechnology has revolutionized the field of medicine with versatile potential capabilities for both the diagnosis, as well as the treatment, of retinoblastoma via the targeted and controlled delivery of anticancer drugs via binding to the overexpressed retinoblastoma gene. Nanotechnology has also generated massive advancements in the treatment of retinoblastoma based on the use of surface-tailored multi-functionalized nanocarriers; overexpressed receptor-based nanocarriers ligands (folate, galactose, and hyaluronic acid); lipid-based nanocarriers; and metallic nanocarriers. These nanocarriers seem to benchmark in mitigating a plethora of malignant retinoblastoma via targeted delivery at a specified site, resulting in programmed apoptosis in cancer cells. The effectiveness of these nanoplatforms in diagnosing and treating intraocular cancers such as retinoblastoma has not been properly discussed, despite the increasing significance of nanomedicine in cancer management. This article reviewed the recent milestones and future development areas in the field of intraocular drug delivery and diagnostic platforms focused on nanotechnology.
Rabia Arshad; Mahmood Barani; Abbas Rahdar; Saman Sargazi; Magali Cucchiarini; Sadanand Pandey; Misook Kang. Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma. Biosensors 2021, 11, 97 .
AMA StyleRabia Arshad, Mahmood Barani, Abbas Rahdar, Saman Sargazi, Magali Cucchiarini, Sadanand Pandey, Misook Kang. Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma. Biosensors. 2021; 11 (4):97.
Chicago/Turabian StyleRabia Arshad; Mahmood Barani; Abbas Rahdar; Saman Sargazi; Magali Cucchiarini; Sadanand Pandey; Misook Kang. 2021. "Multi-Functionalized Nanomaterials and Nanoparticles for Diagnosis and Treatment of Retinoblastoma." Biosensors 11, no. 4: 97.
Curcumin is known to exhibit antioxidant and tissue-healing properties and has recently attracted the attention of the biomedical community for potential use in advanced therapies. This work reports the formulation and characterization of oil-in-water F127 microemulsions to enhance the bioavailability of curcumin Microemulsions showed a high encapsulation efficiency and prolonged release. To investigate the interactions of curcumin with one unit of the polymeric chain of surfactant F127, ethyl butyrate, and sodium octanoate, as well as the interaction between ethyl butyrate and one unit of the F127 polymer chain, the Density Functional Theory (DFT) calculations at the M06-2X level of theory, were performed in water solution. The MTT assay was used to assess the cytotoxicity of free and encapsulated curcumin on non-malignant and malignant cell lines. Combination effects were calculated according to Chou-Talalay’s principles. Results of in vitro studies indicated that MCF7 and HepG2 cells were more sensitive to curcumin microemulsions. Moreover, a synergistic relationship was observed between curcumin microemulsions and cisplatin in all affected fractions of MCF7 and HepG2 cells (CI < 0.9). For in vivo investigation, thioacetamide-intoxicated rats received thioacetamide (100 mg/kg Sc) followed by curcumin microemulsions (30 mg/kg Ip). Thioacetamide-intoxicated rats showed elevated serum liver enzymes, blood urea nitrogen (BUN), and creatinine levels, and a significant reduction in liver superoxide dismutase (SOD) and catalase (CAT) activities (p < 0.05). Curcumin microemulsions reduced liver enzymes and serum creatinine and increased the activity of antioxidant enzymes in thioacetamide-treated rats in comparison to the untreated thioacetamide-intoxicated group. Histopathological investigations confirmed the biochemical findings. Overall, the current results showed the desirable hepatoprotective, nephroprotective, and anti-cancer effects of curcumin microemulsions.
Abbas Rahdar; Mohammad Hajinezhad; Saman Sargazi; Maryam Zaboli; Mahmood Barani; Francesco Baino; Muhammad Bilal; Esmael Sanchooli. Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies. Nanomaterials 2021, 11, 817 .
AMA StyleAbbas Rahdar, Mohammad Hajinezhad, Saman Sargazi, Maryam Zaboli, Mahmood Barani, Francesco Baino, Muhammad Bilal, Esmael Sanchooli. Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies. Nanomaterials. 2021; 11 (3):817.
Chicago/Turabian StyleAbbas Rahdar; Mohammad Hajinezhad; Saman Sargazi; Maryam Zaboli; Mahmood Barani; Francesco Baino; Muhammad Bilal; Esmael Sanchooli. 2021. "Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies." Nanomaterials 11, no. 3: 817.