The effects of operational conditions such as permeate recirculation velocity, mixing intensity, and trans-membrane temperature on the performances of hydrophobic polyethylene (PE) hollow-fiber membrane were investigated by operating the submerged direct contact membrane distillation (SDCMD) process treating a synthetic low-strength wastewater. Permeate flux of the membrane increased with increasing a permeate recirculation velocity through the fiber lumen. However, the effectiveness was less pronounced as the velocity was higher than 0.5 m/s. Increasing rotational speed to 600 rpm, which can lead to mixing intensity from a bulk wastewater toward hollow-fiber membrane, enhanced permeate flux. Feed temperature played a more significant role in enhancing permeate flux rather than a permeate temperature under constant trans-membrane temperature. The SDCMD process treating a synthetic low-strength wastewater achieved an excellent rejection efficiency which is higher than 97.8% for both chemical oxygen demand (COD_Cr) and total phosphorus (T-P) due to the hydrophobic property of membrane material which can allow water vapor through membrane. However, the rejection efficiency of the ammonia nitrogen (NH₃-N) was relatively low at about 87.5% because ammonia gas could be volatized easily through membrane pores in SDCMD operation. In a long-term operation of the SDCMD process, the permeate flux decreased significantly due to progressive formation of inorganic scaling on membrane.