Prof. Catherine Pastor

Catherine Pastor received her MD in 1989 and her PhD on "The modifications of hepatic circulation and functions during sepsis: role of nitric oxide" in 1995 at the University of Paris (France). Between 1992 and 1994, she studied the role of hepatic nitric oxide in the regulatory functions of the liver at the University Hospital of Pittsburgh (US). Since then, she has been appointed director of a research laboratory at the University Hospital of Geneva (Switzerland). In 2013, she became Professor at the Medical University of Paris (France). Her research topics focused on acute pancreatitis, regulation of perfusion and functions in liver diseases, septic shock, and liver transplantation. More recently, she investigated the pharmacokinetics of hepatobiliary drugs, contrast agents, and tracers that enter into hepatocytes through the sinusoidal transporters OATPs and are excreted into bile through the canalicular transporter MRP2. Understanding the hepatocyte pharmacokinetics of hepatobiliary compounds in human and experimental diseases will remain her main research topic in the future. The experimental model she uses for these investigations is the isolated and perfused rat liver preparation.