In this review, we first briefly introduce the general knowledge of glass–ceramics, including the discovery and development, the application, the microstructure, and the manufacturing of glass–ceramics. Second, the review presents a detailed description of glass–ceramics in dentistry. In this part, the history, property requirements, and manufacturing techniques of dental glass–ceramics are reviewed. The review provided a brief description of the most prevalent clinically used examples of dental glass–ceramics, namely, mica, leucite, and lithium disilicate glass–ceramics. In addition, we also introduce the newly developed ZrO₂–SiO₂ nanocrystalline glass–ceramics that show great potential as a new generation of dental glass–ceramics. Traditional strengthening mechanisms of glass–ceramics, including interlocking, ZrO₂–reinforced, and thermal residual stress effects, are discussed. Finally, a perspective and outlook for future directions in developing new dental glass–ceramics is provided to offer inspiration to the dental materials community.