Brain tumor segmentation (BTS) in magnetic resonance image (MRI) is crucial for brain tumor diagnosis, cancer management and research purposes. With the great success of the ten-year BraTS challenges as well as the advances of CNN and Transformer algorithms, a lot of outstanding BTS models have been proposed to tackle the difficulties of BTS in different technical aspects. However, existing studies hardly consider how to fuse the multi-modality images in a reasonable manner. In this paper, we leverage the clinical knowledge of how radiologists diagnose brain tumors from multiple MRI modalities and propose a clinical knowledge-driven brain tumor segmentation model, called CKD-TransBTS. Instead of directly concatenating all the modalities, we re-organize the input modalities by separating them into two groups according to the imaging principle of MRI. A dual-branch hybrid encoder with the proposed modality-correlated cross-attention block (MCCA) is designed to extract the multi-modality image features. The proposed model inherits the strengths from both Transformer and CNN with the local feature representation ability for precise lesion boundaries and long-range feature extraction for 3D volumetric images. To bridge the gap between Transformer and CNN features, we propose a Trans&CNN Feature Calibration block (TCFC) in the decoder. We compare the proposed model with six CNN-based models and six transformer-based models on the BraTS 2021 challenge dataset. Extensive experiments demonstrate that the proposed model achieves state-of-the-art brain tumor segmentation performance compared with all the competitors.

Tissue-level semantic segmentation is a vital step in computational pathology. Fully-supervised models have already achieved outstanding performance with dense pixel-level annotations. However, drawing such labels on the giga-pixel whole slide images is extremely expensive and time-consuming. In this paper, we use only patch-level classification labels to achieve tissue semantic segmentation on histopathology images, finally reducing the annotation efforts. We propose a two-step model including a classification and a segmentation phases. In the classification phase, we propose a CAM-based model to generate pseudo masks by patch-level labels. In the segmentation phase, we achieve tissue semantic segmentation by our propose Multi-Layer Pseudo-Supervision. Several technical novelties have been proposed to reduce the information gap between pixel-level and patch-level annotations. As a part of this paper, we introduce a new weakly-supervised semantic segmentation (WSSS) dataset for lung adenocarcinoma (LUAD-HistoSeg). We conduct several experiments to evaluate our proposed model on two datasets. Our proposed model outperforms five state-of-the-art WSSS approaches. Note that we can achieve comparable quantitative and qualitative results with the fully-supervised model, with only around a 2% gap for MIoU and FwIoU. By comparing with manual labeling on a randomly sampled 100 patches dataset, patch-level labeling can greatly reduce the annotation time from hours to minutes. The source code and the released datasets are available at: https://github.com/ChuHan89/WSSS-Tissue.

High dimensional data classification with very limited labeled training data is a challenging task in the area of data mining. In order to tackle this task, we first propose a feature selection-based semi-supervised classifier ensemble framework (FSCE) to perform high dimensional data classification. Then, we design an adaptive semi-supervised classifier ensemble framework (ASCE) to improve the performance of FSCE. When compared with FSCE, ASCE is characterized by an adaptive feature selection process, an adaptive weighting process (AWP), and an auxiliary training set generation process (ATSGP). The adaptive feature selection process generates a set of compact subspaces based on the selected attributes obtained by the feature selection algorithms, while the AWP associates each basic semi-supervised classifier in the ensemble with a weight value. The ATSGP enlarges the training set with unlabeled samples. In addition, a set of nonparametric tests are adopted to compare multiple semi-supervised classifier ensemble (SSCE)approaches over different datasets. The experiments on 20 high dimensional real-world datasets show that: 1) the two adaptive processes in ASCE are useful for improving the performance of the SSCE approach and 2) ASCE works well on high dimensional datasets with very limited labeled training data, and outperforms most state-of-the-art SSCE approaches.

Traditional cluster ensemble approaches have several limitations. (1) Few make use of prior knowledge provided by experts. (2) It is difficult to achieve good performance in high-dimensional datasets. (3) All of the weight values of the ensemble members are equal, which ignores different contributions from different ensemble members. (4) Not all pairwise constraints contribute to the final result. In the face of this situation, we propose double weighting semi-supervised ensemble clustering based on selected constraint projection(DCECP) to address these limitations. Specifically, DCECP first adopts the random subspace technique in combination with the constraint projection procedure to handle high-dimensional datasets. Second, it treats prior knowledge of experts as pairwise constraints, and assigns different subsets of pairwise constraints to different ensemble members. An adaptive ensemble member weighting process is designed to associate different weight values with different ensemble members. Third, the weighted normalized cut algorithm is adopted to summarize clustering solutions and generate the final result. Finally, nonparametric statistical tests are used to compare multiple algorithms on real-world datasets. Our experiments on 15 high-dimensional datasets show that DCECP performs better than most clustering algorithms.

Crowd counting is challenging due to unconstrained imaging factors, e.g., background clutters, non-uniform distribution of people, large scale and perspective variations. Dealing with these problems using deep neural networks requires rich prior knowledge and multi-scale contextual representations. In this paper, we propose a Cross-stage Refinement Network (CRNet) that can refine predicted density maps progressively based on hierarchical multi-level density priors. In particular, CRNet is composed of several fully convolutional networks. They are stacked together recursively with the previous output as the next input, and each of them serves to utilize previous density output to gradually correct prediction errors of crowd areas and refine the predicted density maps at different stages. Cross-stage multi-level density priors are further exploited in our recurrent framework by the cross-stage skip layers based on ConvLSTM. To cope with different challenges of unconstrained crowd scenes, we explore different crowd-specific data augmentation methods to mimic real-world scenarios and enrich crowd feature representations from different aspects. Extensive experiments show the proposed method achieves superior performances against state-of-the-art methods on four widely-used challenging benchmarks in terms of counting accuracy and density map quality. Code and models are available at this link.

Histopathological tissue classification is a simpler way to achieve semantic segmentation for the whole slide images, which can alleviate the requirement of pixel-level dense annotations. Existing works mostly leverage the popular CNN classification backbones in computer vision to achieve histopathological tissue classification. In this paper, we propose a super lightweight plug-and-play module, named Pyramidal Deep-Broad Learning (PDBL), for any well-trained classification backbone to improve the classification performance without a re-training burden. For each patch, we construct a multi-resolution image pyramid to obtain the pyramidal contextual information. For each level in the pyramid, we extract the multi-scale deep-broad features by our proposed Deep-Broad block (DB-block). We equip PDBL in three popular classification backbones, ShuffLeNetV2, EfficientNetb0, and ResNet50 to evaluate the effectiveness and efficiency of our proposed module on two datasets (Kather Multiclass Dataset and the LC25000 Dataset). Experimental results demonstrate the proposed PDBL can steadily improve the tissue-level classification performance for any CNN backbones, especially for the lightweight models when given a small among of training samples (less than 10%). It greatly saves the computational resources and annotation efforts. The source code is available at: https://github.com/linjiatai/PDBL .