Stephanie S. Watowich

Prof. Stephanie S. Watowich

Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
orcid

Research Focus & Metrics

Academic Career Length

35Years (1992-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2008 in Immunity
Verified
Journal Article
Closed access
Xuexian YangXuexian Yang
Xuexian Yang
BPBhanu P. Pappu
Bhanu P. Pappu
RNRoza Nurieva
Roza Nurieva
AAAskar Akimzhanov
Askar Akimzhanov
HKHong Soon Kang
Hong Soon Kang
CDChen Dong
Chen Dong

20 June 2007 in Nature
Verified
Journal Article
Closed access
RNRoza Nurieva
Roza Nurieva
Xuexian YangXuexian Yang
Xuexian Yang
GMGustavo Martinez
Gustavo Martinez
YZYongliang Zhang
Yongliang Zhang
APAthanasia D. Panopoulos
Athanasia D. Panopoulos
CDChen Dong
Chen Dong

1 March 2007 in Journal of Biological Chemistry
Verified
Journal Article
Open access
PDF file
Xuexian YangXuexian Yang
Xuexian Yang
APAthanasia D. Panopoulos
Athanasia D. Panopoulos
RNRoza Nurieva
Roza Nurieva
SCSeon Hee Chang
Seon Hee Chang
DWDemin Wang
Demin Wang
CDChen Dong
Chen Dong
Interleukin-17 (IL-17)-producing helper T (TH) cells, named as THIL-17, TH17, or inflammatory TH (THi), have been recently identified as a novel effector lineage. However, how cytokine signals mediate THi differentiation is unclear. We found that IL-6 functioned to up-regulate IL-23R and that IL-23 synergized with IL-6 in promoting THi generation. STAT3, activated by both IL-6 and IL-23, plays a critical role in THi development. A hyperactive form of STAT3 promoted THi development, whereas this differentiation process was greatly impaired in STAT3-deficient T cells. Moreover, STAT3 regulated the expression of retinoic acid receptor-related orphan receptor γ-T (RORγt), a THi-specific transcriptional regulator; STAT3 deficiency impaired RORγt expression and led to elevated expression of T-box expressed in T cells (T-bet) and Forkhead box P3 (Foxp3). Our data thus demonstrate a pathway whereby cytokines regulate THi differentiation through a selective STAT transcription factor that functions to regulate lineage-specific gene expression.

1 July 2008 in Immunity
Verified
Journal Article
Closed access
RNRoza I. Nurieva
Roza I. Nurieva
YCYeonseok Chung
Yeonseok Chung
DHDaehee Hwang
Daehee Hwang
Xuexian YangXuexian Yang
Xuexian Yang
HKHong Soon Kang
Hong Soon Kang
CDChen Dong
Chen Dong

1 April 2009 in Immunity
Verified
Journal Article
Closed access
YCYeonseok Chung
Yeonseok Chung
SCSeon Hee Chang
Seon Hee Chang
GMGustavo J. Martinez
Gustavo J. Martinez
Xuexian YangXuexian Yang
Xuexian Yang
RNRoza Nurieva
Roza Nurieva
CDChen Dong
Chen Dong

1 July 2008 in Immunity
Verified
Journal Article
Closed access
Xuexian YangXuexian Yang
Xuexian Yang
RNRoza Nurieva
Roza Nurieva
GMGustavo J. Martinez
Gustavo J. Martinez
HKHong Soon Kang
Hong Soon Kang
YCYeonseok Chung
Yeonseok Chung
CDChen Dong
Chen Dong