In this paper, a new kind of mathematical modeling is studied by providing a five-compartmental system of differential equations with respect to new hybrid generalized fractal-fractional derivatives. For the first time, we design a model of giving up smoking to analyze its dynamical behaviors by considering two parameters of such generalized operators; i.e., fractal dimension and fractional order. We apply a special sub-category of increasing functions to investigate the existence of solutions. Uniqueness property is derived by a standard method based on the Lipschitz rule. After proving stability property, the equilibrium points are obtained and asymptotically stable solutions are studied. Finally, we illustrate all analytical results and findings via numerical algorithms and graphs obtained by Lagrangian piece-wise interpolation, and discuss all behaviors of the relevant solutions in the fractal-fractional system.