In recent years, the research on optical remote sensing images has received greater and greater attention. Object detection, as one of the most challenging tasks in the area of remote sensing, has been remarkably promoted by convolutional neural network (CNN)-based methods like You Only Look Once (YOLO) and Faster R-CNN. However, due to the complexity of backgrounds and the distinctive object distribution, directly applying these general object detection methods to the remote sensing object detection usually renders poor performance. To tackle this problem, a highly efficient and robust framework based on YOLO is proposed. We devise and integrate VaryBlock to the architecture which effectively offsets some of the information loss caused by downsampling. In addition, some techniques are utilized to facilitate the performance and to avoid overfitting. Experimental results show that our proposed method can enormously improve the mean average precision by a large margin on the NWPU VHR-10 dataset.