Ana Lleo obtained her degree in Medicine from the University of Milan, Italy, in 2000, and has been licensed to practice general medicine throughout Europe since July 2001. She completed her clinical training and received the Board Certification in Internal Medicine in 2006. She was a researcher between October 2006 and April 2010 at the University of California-Davis (Davis, CA, USA) in the division of Clinical Immunology and Rheumatology directed by Prof. M. Eric Gershwin. From 2017 she has assumed the responsibility of the Hepatobiliary Immunopathology Laboratory. Since Jan 2022 she has held a position as Professor of Internal Medicine at Humanitas University. She has co-authored many publications in peer-reviewed journals. Her areas of scientific expertise are biliary disorders, with particular attention to cholangiocyte biology and the liver's innate immune response. She specifically works on cholangiocarcinoma, the cancer arising from epithelial cells lining intrahepatic or extrahepatic biliary ducts. Her work has been funded by the Italian Ministry of Health and AIRC. She is a member of the “European Network for the Study of Cholangiocarcinoma (ENS-CCA)”—A scientific network that aims to define the clinical management and treatment of cholangiocarcinoma in Europe.