The aim of this paper is to study the influence of rail flexibility when a wheel/rail wear prediction model that computes the material loss based on an energy approach is used. The wheel/rail wear model used in this investigation is a simplified combined wear hypothesis that is based on the frictional energy loss in the contact patch. In order to account for wear and its distribution in a profiled wheel surface, the contact forces, creepages and location of the wheel/rail contact points are first calculated using a fully nonlinear multibody system (MBS) and three-dimensional contact formulations that account for the rail flexibility. The contact forces, creepages and contact point locations are defined as nonlinear functions of the rail deformations. These nonlinear expressions are used in the wear calculations. The wear distribution is considered to be proportional to the normal force in the contact area. Numerical simulations are first performed in order to compare between the results obtained using the simplified wheel/rail wear model and the results obtained using Archard’s wear model with a focus on sliding when the track is modeled as a rigid body. This simplified wear model is then used in the simulation of the MBS vehicle model in the case of a flexible body track, in which the rails are modeled using the finite element floating frame of reference approach and modal reduction techniques. The effect of the rail deformation on the wear results are examined by comparing these results with those obtained using the rigid-body track model.