Ramón Mazzucchelli

Prof. Ramón Mazzucchelli

Rheumatology Unit. Hospital Universitario Fundación Alcorcón
orcid

Research Focus & Metrics

Academic Career Length

37Years (1990-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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4 July 2019 in Journal of Orthopaedic Surgery and Research
Verified
Journal Article
Open access
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OGOlalla Guzon-Illescas
Olalla Guzon-Illescas
EPElia Pérez
Elia Pérez
NVNatalia Crespí Villarias
Natalia Crespí Villarias
FDFrancisco Javier Quirós Donate
Francisco Javier Quirós Donate
MPMarina Peña
Marina Peña
Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
It is known that mortality after hip fracture increases compared to the general population; the trend in mortality is a controversial issue. The objective of this study is to examine incidence, trends, and factors associated with mortality in patients with osteoporotic hip fractures. This is a retrospective cohort study that uses the Registry for Hospital Discharges of the National Health System of our hospital. Patients older than 45 having an osteoporotic hip fracture between 1999 and 2015 were identified. Demographic data and comorbidities were obtained. A survival analysis was performed (Cox regression and Kaplan-Meier). Incidence rate, standardized death rate (SDR), trend (Poisson regression), and risk (hazard ratio) were calculated. During 1999–2015, in our hospital, there were a total of 3992 patients admitted due to osteoporotic hip fracture. Out of these 3992 patients, 3109 patients (77.9%) were women with an average age of 84.47 years (SD 8.45) and 803 (22.1%) were men with an average age of 81.64 years (SD 10.08). The cumulative incidence of mortality was 69.38%. The cumulative mortality rate for 12 months was 33%. The annual mortality was 144.9/1000 patients/year. The 1-year mortality rate increased significantly by 2% per year (IRR 1.020, CI95% 1.008–1.033). The median overall survival was 886 days (CI95% 836–951). The probability of mortality density for a period of 10 years following a hip fracture was 16% for women and 25% for men (first 90 days). The SDR was 8.3 (CI95% 7.98–8.59). Variables that showed statistically significant association with mortality were aged over 75, masculine, institutionalization, mild to severe liver disease, chronic kidney disease, COPD, dementia, heart failure, diabetes, the Charlson Index > 2 , presence of vision disorders and hearing impairment, incontinence, and Downton scale. For the last 17 years, an increase of mortality for patients with hip fracture and a higher mortality rate in men than in women were observed. Institutionalization combined with comorbidities is associated with a higher mortality.

9 August 2018 in Osteoporosis International
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Journal Article
Closed access
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Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
NVN. Crespi Villarias
N. Crespi Villarias
EFE. Perez Fernandez
E. Perez Fernandez
MRM. L. Durban Reguera
M. L. Durban Reguera
AGA. Garcia-Vadillo
A. Garcia-Vadillo
AMA. Gil de Miguel
A. Gil de Miguel

1 February 1993 in Seminars in Arthritis and Rheumatism
Verified
Journal Article
Closed access
PDF file
ECEduardo Cuende
Eduardo Cuende
CBCarmen Barbadillo
Carmen Barbadillo
Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
CICarlos Isasi
Carlos Isasi
ATAngeles Trujillo
Angeles Trujillo
JAJosé L. Andréu
José L. Andréu

15 March 2018 in Archives of Osteoporosis
Verified
Journal Article
Closed access
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Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
NCNatalia Crespí-Villarías
Natalia Crespí-Villarías
EPElia Pérez-Fernández
Elia Pérez-Fernández
MDMaria L. Durbán
Maria L. Durbán
OIOlalla Guzón Illescas
Olalla Guzón Illescas
AMAngel Gil de Miguel
Angel Gil de Miguel

4 June 2018 in RMD Open
Verified
Journal Article
Open access
PDF file
Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
EFElia Pérez Fernandez
Elia Pérez Fernandez
NCNatalia Crespí-Villarías
Natalia Crespí-Villarías
JQJavier Quirós-Donate
Javier Quirós-Donate
AVAlberto García Vadillo
Alberto García Vadillo
GCGil Rodriguez Caravaca
Gil Rodriguez Caravaca
Purpose To analyse trends in hip fracture (HF) rates in patients with rheumatoid arthritis (RA) over an extended time period (17 years). Methods This observational retrospective survey was performed by reviewing data from the National Surveillance System for Hospital Data, which includes more than 98% of Spanish hospitals. All hospitalisations of patients with RA and HF that were reported from 1999 to 2015 were analysed. Codes were selected using the Ninth International Classification of Diseases, Clinical Modification: ICD-9-CM: RA 714.0 to 714.9 and HF 820.0 to 820.3. The crude and age-adjusted incidence rate of HF was calculated by age and sex strata over the last 17 years. General lineal models were used to analyse trends. Results Between 1999 and 2015, 6656 HFs occurred in patients with RA of all ages (84.25% women, mean age 77.5 and 15.75% men, mean age 76.37). The age-adjusted osteoporotic HF rate was 221.85/100 000 RA persons/ year (women 227.97; men 179.06). The HF incidence rate increased yearly by 3.1% (95% CI 2.1 to 4.0) during the 1999–2015 period (p<0.001) and was more pronounced in men (3.5% (95% CI 2.1 to 4.9)) than in women (3.1% (95% CI 2.3 to 4.1)). The female to male ratio decreased from 1.54 in 1999 to 1.14 in 2015. The average length of hospital stays (ALHS) decreased (p<0.001) from 16.76 days (SD 15.3) in 1999 to 10.78 days (SD 7.72) in 2015. Age at the time of hospitalisation increased (p<0.001) from 75.3 years (SD 9.33) in 1999 to 79.92 years (SD 9.47) in 2015. There was a total of 326 (4.9%) deaths during admission, 247 (4.4%) in women and 79 (7.5%) in men (p<0.001). Conclusion In Spain, despite the advances that have taken place in controlling disease activity and in treating osteoporosis, the incidence rate of HF increased in both male and female patients with RA.

27 September 2017 in Archives of Osteoporosis
Verified
Journal Article
Closed access
PDF file
Ramón MazzucchelliRamón Mazzucchelli
Ramón Mazzucchelli
EPElia Pérez-Fernández
Elia Pérez-Fernández
NCNatalia Crespí-Villarías
Natalia Crespí-Villarías
AGAlberto García-Vadillo
Alberto García-Vadillo
GRGil Rodriguez-Caravaca
Gil Rodriguez-Caravaca
LCLoreto Carmona
Loreto Carmona