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Kristina Vlahoviček-Kahlina
Department of Chemistry, Faculty of Agriculture, University of Zagreb, Svetošimunska 25, 10000 Zagreb, Croatia

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Journal article
Published: 30 May 2021 in Sustainability
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Alternatives and replacements for synthetic chemical-based plant protectants are required. In this study biopolymeric microspheres containing arthropod-derived apitoxin are explored as a possible novel environmentally friendly formulation for plant protection. Here we document the optimization process for microencapsulation of apitoxin into a stable formulation, for ready use in agricultural applications. Efficacy trials were carried out on three different beetle species at various developmental stages (Leptinotarsa decemlineata (Say, 1824.), Tenebrio molitor (Linnaeus, 1758.), Sitophilus granarius (Linnaeus, 1758.)). The encapsulated apitoxin has a steady initial and long residual effect, due to the slow release of apitoxin which is one of its main advantages over other conventional control methods. Microspheres loaded with apitoxin have a detrimental effect on insects, of which it is significantly better gastric compared to contact action (due to pH). The results showed that the highest and fastest mortality was obtained when the highest concentrations (0.6%) were applied, chosen to be economically acceptable. These important findings contribute to knowledge on the application and development of encapsulated apitoxin formulations, and their effectiveness, as an alternative eco-friendly control method in agricultural production.

ACS Style

Darija Lemic; Matej Orešković; Katarina Mikac; Marijan Marijan; Slaven Jurić; Kristina Vlahoviček-Kahlina; Marko Vinceković. Sustainable Pest Management Using Biodegradable Apitoxin-Loaded Calcium-Alginate Microspheres. Sustainability 2021, 13, 6167 .

AMA Style

Darija Lemic, Matej Orešković, Katarina Mikac, Marijan Marijan, Slaven Jurić, Kristina Vlahoviček-Kahlina, Marko Vinceković. Sustainable Pest Management Using Biodegradable Apitoxin-Loaded Calcium-Alginate Microspheres. Sustainability. 2021; 13 (11):6167.

Chicago/Turabian Style

Darija Lemic; Matej Orešković; Katarina Mikac; Marijan Marijan; Slaven Jurić; Kristina Vlahoviček-Kahlina; Marko Vinceković. 2021. "Sustainable Pest Management Using Biodegradable Apitoxin-Loaded Calcium-Alginate Microspheres." Sustainability 13, no. 11: 6167.

Journal article
Published: 06 March 2021 in International Journal of Molecular Sciences
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A new copper complex, trans-diaqua-trans-bis [1-hydroxy-1,2-di (methoxycarbonyl) ethenato] copper (abbreviation Cu(II) complex), was synthesized and its plant growth regulation properties were investigated. The results show a sharp dependence of growth regulation activity of the Cu(II) complex on the type of culture and its concentration. New plant growth regulator accelerated the development of the corn root system (the increase in both length and weight) but showed a smaller effect on the development of the wheat and barley root systems. Stimulation of corn growth decreased with increasing Cu(II) complex concentration from 0.0001% to 0.01% (inhibition at high concentrations—0.01%). The development of corn stems was also accelerated but to a lesser extent. Chitosan-coated calcium alginate microcapsules suitable for delivery of Cu(II) complex to plants were prepared and characterized. Analysis of the FTIR spectrum showed that complex molecular interactions between functional groups of microcapsule constituents include mainly electrostatic interactions and hydrogen bonds. Microcapsules surface exhibits a soft granular surface structure with substructures consisting of abundant smaller particles with reduced surface roughness. Release profile analysis showed Fickian diffusion is the rate-controlling mechanism of Cu(II) complex releasing. The obtained results give new insights into the complexity of the interaction between the Cu(II) complex and microcapsule formulation constituents, which can be of great help in accelerating product development for the application in agriculture

ACS Style

Darikha Kudasova; Botagoz Mutaliyeva; Kristina Vlahoviček-Kahlina; Slaven Jurić; Marijan Marijan; Svetlana Khalus; Alexander Prosyanik; Suzana Šegota; Nikola Španić; Marko Vinceković. Encapsulation of Synthesized Plant Growth Regulator Based on Copper(II) Complex in Chitosan/Alginate Microcapsules. International Journal of Molecular Sciences 2021, 22, 2663 .

AMA Style

Darikha Kudasova, Botagoz Mutaliyeva, Kristina Vlahoviček-Kahlina, Slaven Jurić, Marijan Marijan, Svetlana Khalus, Alexander Prosyanik, Suzana Šegota, Nikola Španić, Marko Vinceković. Encapsulation of Synthesized Plant Growth Regulator Based on Copper(II) Complex in Chitosan/Alginate Microcapsules. International Journal of Molecular Sciences. 2021; 22 (5):2663.

Chicago/Turabian Style

Darikha Kudasova; Botagoz Mutaliyeva; Kristina Vlahoviček-Kahlina; Slaven Jurić; Marijan Marijan; Svetlana Khalus; Alexander Prosyanik; Suzana Šegota; Nikola Španić; Marko Vinceković. 2021. "Encapsulation of Synthesized Plant Growth Regulator Based on Copper(II) Complex in Chitosan/Alginate Microcapsules." International Journal of Molecular Sciences 22, no. 5: 2663.

Journal article
Published: 12 February 2021 in International Journal of Molecular Sciences
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Novel plant growth regulators (PGRs) based on the derivatives of dehydroamino acids 2,3-dehydroaspartic acid dimethyl ester (PGR1), Z-isomer of the potassium salt of 2-amino-3-methoxycarbonylacrylic acid (PGR2) and 1-methyl-3-methylamino-maleimide (PGR3) have been synthesized and their growth-regulating properties investigated. Laboratory testing revealed their plant growth-regulating activity. PGR1 showing the most stimulating activity on all laboratory tested cultures were used in field experiments. Results showed that PGR1 is a highly effective environmentally friendly plant growth regulator with effects on different crops. Biopolymeric microcapsule formulations (chitosan/alginate microcapsule loaded with PGR) suitable for application in agriculture were prepared and characterized. Physicochemical properties and release profiles of PGRs from microcapsule formulations depend on the molecular interactions between microcapsule constituents including mainly electrostatic interactions and hydrogen bonds. The differences in the microcapsule formulations structure did not affect the mechanism of PGRs release which was identified as diffusion through microcapsules. The obtained results opened a perspective for the future use of microcapsule formulations as new promising agroformulations with a sustained and target release for plant growth regulation.

ACS Style

Kristina Vlahoviček-Kahlina; Slaven Jurić; Marijan Marijan; Botagoz Mutaliyeva; Svetlana Khalus; Alexander Prosyanik; Marko Vinceković. Synthesis, Characterization, and Encapsulation of Novel Plant Growth Regulators (PGRs) in Biopolymer Matrices. International Journal of Molecular Sciences 2021, 22, 1847 .

AMA Style

Kristina Vlahoviček-Kahlina, Slaven Jurić, Marijan Marijan, Botagoz Mutaliyeva, Svetlana Khalus, Alexander Prosyanik, Marko Vinceković. Synthesis, Characterization, and Encapsulation of Novel Plant Growth Regulators (PGRs) in Biopolymer Matrices. International Journal of Molecular Sciences. 2021; 22 (4):1847.

Chicago/Turabian Style

Kristina Vlahoviček-Kahlina; Slaven Jurić; Marijan Marijan; Botagoz Mutaliyeva; Svetlana Khalus; Alexander Prosyanik; Marko Vinceković. 2021. "Synthesis, Characterization, and Encapsulation of Novel Plant Growth Regulators (PGRs) in Biopolymer Matrices." International Journal of Molecular Sciences 22, no. 4: 1847.

Journal article
Published: 03 December 2020 in Sustainability
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The brown marmorated stink bug (Halyomorpha halys Stål, 1855) is an invasive polyphagous species that threatens fruit growing both in the United States and Europe. Many pesticide active ingredients have been studied in H. halys management, but for sustainable fruit growing, which implies the reduction of chemical harm to the environment, new safe insecticides should be implemented into the practice. For this purpose, novel green insecticide based on natural polyphenols of species Stevia rebaudiana (Bertoni) Bertoni and Aronia melanocarpa (Michx.) Elliott 1821 was developed. Stevia leaves (SLE) and Aronia pomace (APE) aqueous extracts were prepared using the ultrasound-assisted extraction method. Optimal extraction conditions for bioactive compounds (total polyphenols, flavonoids, anthocyanins, and flavan-3-ols, respectively) and antioxidant activity were determined using response surface methodology. Bioactive compounds rich SLE and APE were encapsulated in calcium alginate microparticles by the ionic gelation method. Physicochemical characteristics (morphology, size, encapsulation efficiency, loading capacity, and swelling) of microparticles showed very good properties with especially high encapsulation efficiency. Fitting to simple Korsmeyer–Peppa’s empirical model revealed that the underlying release mechanism of polyphenols is Fickian diffusion. SLE loaded microparticles showed very good pesticidal efficiency against Halyomorpha halys, especially on younger larval stages after both contact and digestive treatment. Microparticles loaded with APE did not achieve satisfactory digestive efficiency, but a certain toxic impact has been observed at contact application on all H. halys growth stages. Microparticles loaded with SLS exhibited prolonged insecticidal action against H. halys and could be a potential candidate as a green insecticide whose application could increase fruit growing safety.

ACS Style

Ivana Živković; Slaven Jurić; Marko Vinceković; Marija Galešić; Marijan Marijan; Kristina Vlahovićek-Kahlina; Katarina Mikac; Darija Lemic. Polyphenol-Based Microencapsulated Extracts as Novel Green Insecticides for Sustainable Management of Polyphagous Brown Marmorated Stink Bug (Halyomorpha halys Stål, 1855). Sustainability 2020, 12, 10079 .

AMA Style

Ivana Živković, Slaven Jurić, Marko Vinceković, Marija Galešić, Marijan Marijan, Kristina Vlahovićek-Kahlina, Katarina Mikac, Darija Lemic. Polyphenol-Based Microencapsulated Extracts as Novel Green Insecticides for Sustainable Management of Polyphagous Brown Marmorated Stink Bug (Halyomorpha halys Stål, 1855). Sustainability. 2020; 12 (23):10079.

Chicago/Turabian Style

Ivana Živković; Slaven Jurić; Marko Vinceković; Marija Galešić; Marijan Marijan; Kristina Vlahovićek-Kahlina; Katarina Mikac; Darija Lemic. 2020. "Polyphenol-Based Microencapsulated Extracts as Novel Green Insecticides for Sustainable Management of Polyphagous Brown Marmorated Stink Bug (Halyomorpha halys Stål, 1855)." Sustainability 12, no. 23: 10079.

Journal article
Published: 07 October 2020 in Colloids and Surfaces B: Biointerfaces
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Alginate microspheres loaded with two fermentation active agents, calcium cations and strain LS0296 identified as Lactobacillus sakei, have been prepared and characterized. The role of calcium cation is twofold, it acts as gelling cation and as fermentation active agent. Encapsulation and the presence of calcium ions in the same compartment do not inhibit the activity of LS0296. Molecular interactions in microspheres are complex, including mainly hydrogen bonds and electrostatic interactions. In vitro calcium cations and strain LS0296 release profiles were fitted to the Korsmeyer–Peppas empirical model. The calcium cation release process is driven at first by Fickian diffusion through microspheres and then by anomalous transport kinetics. The in vitro LS0296 release process is driven by Fickian diffusion through microspheres showing a much slower releasing rate than calcium cations. The release of LS0296 strain is followed by a decrease in the pH value. Results obtained give us a new insight into complex interactions between bacterial cultures and microsphere constituents. Prepared formulations of calcium alginate microspheres loaded with LS0296 could be used as a new promising tool and a model for different starter cultures encapsulation and use in the production of fermented foods.

ACS Style

Slaven Jurić; Irina Tanuwidjaja; Mirna Mrkonjić Fuka; Kristina Vlahoviček-Kahlina; Marijan Marijan; Anita Boras; Nikolina Udiković Kolić; Marko Vinceković. Encapsulation of two fermentation agents, Lactobacillus sakei and calcium ions in microspheres. Colloids and Surfaces B: Biointerfaces 2020, 197, 111387 .

AMA Style

Slaven Jurić, Irina Tanuwidjaja, Mirna Mrkonjić Fuka, Kristina Vlahoviček-Kahlina, Marijan Marijan, Anita Boras, Nikolina Udiković Kolić, Marko Vinceković. Encapsulation of two fermentation agents, Lactobacillus sakei and calcium ions in microspheres. Colloids and Surfaces B: Biointerfaces. 2020; 197 ():111387.

Chicago/Turabian Style

Slaven Jurić; Irina Tanuwidjaja; Mirna Mrkonjić Fuka; Kristina Vlahoviček-Kahlina; Marijan Marijan; Anita Boras; Nikolina Udiković Kolić; Marko Vinceković. 2020. "Encapsulation of two fermentation agents, Lactobacillus sakei and calcium ions in microspheres." Colloids and Surfaces B: Biointerfaces 197, no. : 111387.

Journal article
Published: 10 December 2019 in International Journal of Molecular Sciences
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Carbohydrates and their conjugates are the most abundant natural products, with diverse and highly important biological roles. Synthetic glycoconjugates are versatile tools used to probe biological systems and interfere with them. In an endeavor to provide an efficient route to glycomimetics comprising structurally diverse carbohydrate units, we describe herein a robust, stereoselective, multicomponent approach. Isopropylidene-protected carbohydrate-derived aldehydes and ketones were utilized in the Passerini reaction, giving different glycosylated structures in high yields and diastereoselectivities up to 90:10 diastereomeric ratio (d.r). Access to highly valuable building blocks based on α-hydroxy C-glycosyl acids or more complex systems was elaborated by simple post-condensation methodologies.

ACS Style

Kristina Vlahoviček-Kahlina; Josipa Suć Sajko; Ivanka Jerić. C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. International Journal of Molecular Sciences 2019, 20, 6236 .

AMA Style

Kristina Vlahoviček-Kahlina, Josipa Suć Sajko, Ivanka Jerić. C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction. International Journal of Molecular Sciences. 2019; 20 (24):6236.

Chicago/Turabian Style

Kristina Vlahoviček-Kahlina; Josipa Suć Sajko; Ivanka Jerić. 2019. "C-Linked Glycomimetic Libraries Accessed by the Passerini Reaction." International Journal of Molecular Sciences 20, no. 24: 6236.

Journal article
Published: 23 February 2017 in IUCrJ
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Peptidoglycan is a giant molecule that forms the cell wall that surrounds bacterial cells. It is composed of alternating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) residues connected by β-(1,4)-glycosidic bonds and cross-linked with short polypeptide chains. Owing to the increasing antibiotic resistance against drugs targeting peptidoglycan synthesis, studies of enzymes involved in the degradation of peptidoglycan, such as N-acetylglucos-aminidases, may expose new, valuable drug targets. The scientific challenge addressed here is how lysozymes, muramidases which are likely to be the most studied enzymes ever, and bacterial N-acetylglucosaminidases discriminate between two glycosidic bonds that are different in sequence yet chemically equivalent in the same NAG-NAM polymers. In spite of more than fifty years of structural studies of lysozyme, it is still not known how the enzyme selects the bond to be cleaved. Using macromolecular crystallography, chemical synthesis and molecular modelling, this study explains how these two groups of enzymes based on an equivalent structural core exhibit a difference in selectivity. The crystal structures of Staphylococcus aureusN-acetylglucosaminidase autolysin E (AtlE) alone and in complex with fragments of peptidoglycan revealed that N-acetylglucosaminidases and muramidases approach the substrate at alternate glycosidic bond positions from opposite sides. The recognition pocket for NAM residues in the active site of N-acetylglucosaminidases may make them a suitable drug target.

ACS Style

Marko Mihelič; Kristina Vlahoviček-Kahlina; Miha Renko; Stephane Mesnage; Andreja Doberšek; Ajda Taler-Verčič; Andreja Jakas; Dušan Turk. The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers. IUCrJ 2017, 4, 185 -198.

AMA Style

Marko Mihelič, Kristina Vlahoviček-Kahlina, Miha Renko, Stephane Mesnage, Andreja Doberšek, Ajda Taler-Verčič, Andreja Jakas, Dušan Turk. The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers. IUCrJ. 2017; 4 (2):185-198.

Chicago/Turabian Style

Marko Mihelič; Kristina Vlahoviček-Kahlina; Miha Renko; Stephane Mesnage; Andreja Doberšek; Ajda Taler-Verčič; Andreja Jakas; Dušan Turk. 2017. "The mechanism behind the selection of two different cleavage sites in NAG-NAM polymers." IUCrJ 4, no. 2: 185-198.