The north‐striking Tancheng‐Lujiang (Tan‐Lu) fault is a conspicuous and controversial feature of the eastern Asian landscape. Near the southeast extremity of the fault in Anhui Province, we collected paleomagnetic samples at 17 Middle Triassic (T2) and 10 Upper Cretaceous (K2) to lower Cenozoic (E1) sites. T2 remanent magnetizations are interpreted as primary in two of three areas. The three areas are rotated 37° to 137° counterclockwise with respect to the South China Block (SCB) reference direction. K2‐E1 remanent magnetization directions pass regional fold and reversals tests and are not rotated with respect to surrounding areas. Counterclockwise rotation of T2 strata therefore ended before K2 and is attributed to left lateral shear acting along Tan‐Lu during the North China Block (NCB)‐SCB collision. In Shandong Province, 700 km north of the Anhui sites, four areas containing 33 Upper Jurassic (J3) and Cretaceous sites have negligible declination differences, except for one which has dispersed directions. The fold test is inconclusive for this latter area and positive for the other three. Regional concordance of the J3‐E1 paleomagnetic data (including paleolatitudes) together with observed deformation patterns suggest that an extensional regime prevailed in the Late Cretaceous and Cenozoic. Euler pole positions that constrain the North‐South China collision and account for Tan‐Lu motion suggest at least 500 km of sinistral shear took place along the fault, and either (1) subduction and related ultrahigh pressure (UHP) metamorphism occurred near the present location of the Qinling‐Dabieshan and Sulu UHP belts while Tan‐Lu acted as a transform fault that connected the two subduction zones, or (2) Tan‐Lu and Sulu were parts of the same transform fault system and no UHP rocks formed in situ at Sulu. In either case, UHP rocks originally exhumed near Dabieshan could have been transported by plate capture toward Sulu along Tan‐Lu. After North and South China impacted near Dabieshan, the Tan‐Lu fault grew within the SCB as the Dabieshan corner indented the SCB, causing folds in SCB cover rocks to conform to the NCB margin. Late Cretaceous to Cenozoic reactivation of Tan‐Lu, with both right lateral strike‐slip and normal fault motion, occurred as the SCB extruded east relative to the NCB under the influence of the India‐Asia collision.