Aminoglycosides are antibiotics, antifungals, antivirals, and premature termination codon disorder treatments. We review all chemical strategies for their preparation.

Controlled halogenation of chemically versatile substrates is difficult to achieve. Here we describe a unique flavin-dependent halogenase, PltM, which is capable of utilizing a wide range of halides for installation on a diverse array of phenolic compounds, including FDA-approved drugs and natural products, such as terbutaline, fenoterol, resveratrol, and catechin. Crystal structures of PltM in complex with phloroglucinol and FAD in different states yield insight into substrate recognition and the FAD recycling mechanism of this halogenase.

The information about synthesis, resistance, and toxicity of aminoglycosides in all patents from 2011–2015 is presented in details.