Background. Recent studies showed that depression was an independent predictor of mortality from cardiovascular disease in healthy women. Objective. To explore the effect of depression (D) on relative risk (RR) of myocardial infarction (MI) and stroke for 16 years (1995-2010) in the female population aged 25-64 years from Novosibirsk, Russia. Materials and methods. Under the third screening of the WHO ‘‘MONICA-psychosocial’’ (MOPSY) programme, a cohort of women aged 25-64 years (N=560) was surveyed. Women were followed for 16 years for the incidence of MI and stroke (1995-2010). D was measured at the baseline examination by means of test ‘‘MOPSY’’. Participants having stroke, MI, arterial hypertension, coronary artery diseases and diabetes in their medical history at the baseline were excluded from this analysis. Results. The prevalence of D in women aged 25-64 years was 55.2%. With the growth of D levels, positive self-rated health reduced and almost 100% of those women have complaints about their health, but considered the care of their health insufficient. Women with major D significantly extended negative behavioural habits: smoking and unsuccessful attempts to give up, low physical activity, and less likely to follow a diet (healthy food). Major D associated with high job strain and family stress. Relative risk (RR) of MI development in women with D during 16 years of study was higher in 2.53 cases (p<0.05) and risk of stroke was higher in 4.63 cases (p<0.05). Conclusions. The prevalence of D in women aged 25-64 years was >50%. Women with D had a 2.53-fold risk of MI and 4.63-fold risk of stroke during the 16 years of follow-up. Keywords: depression; awareness; attitude to the health; relative risk; myocardial infarction; stroke (Published: 5 August 2013) This paper is part of Supplement 1, 2013, ICCH15 Proceedings. More papers from this Supplement can be found here. Citation: Int J Circumpolar Health 2013, 72: 21223 - http://dx.doi.org/10.3402/ijch.v72i0.21223

Aim. To determine the gender differentiation and dynamics for 22 years of psychosocial factors (PSF) of the risk of cardiovascular disease among the population aged 25-64 years in Russia / Siberia (Novosibirsk). Materials and methods. Representative samples of the population of the city of Novosibirsk under the program of the World Health Organization “MONICA-MOPSY” in 1994-1995 were examined. III screening (men - 657, women - 870, 25-64 years old); IV screening project HAPIEE in 2003-2005 (men - 576, women - 1074, 45-64 years old) and V screening in 2013-2016. (men - 427, women - 548, 25-44 years old). We used Spielberger tests, MONICA-MOPSY tests, the Breckman - Sim test, the “Knowledge and attitude to your health” questionnaire. Results. In an open population of 25-64 years old, high levels of anxiety (T), depression (D), life exhaustion (LM), and hostility (B) were higher in women than in men. In the group of 55-64 years over 10 years, women have increased personality T, decreased D and LM. Over 22 years, in the group of 25-34 years, men and women decreased T and MI, but D and B increased, while women decreased T, LM and B and D. grew. Low and high close contact indices were higher among men. A low index of social ties prevailed in men, and a high index in women. High levels of stress in the family were more common in women, and at work - in men. For 10 years, the level of stress in the family and at work in men has decreased. Sleep disorders in the population in all age groups were more often in women. Conclusion. It was found that women have significantly higher PSF than men, with the exception of stress at work. The decrease in PSF in women and men in the dynamics

Objective. To study the effects of stress at home and at work on the 14-year risk of hypertension in men aged 25–64 years.Design and methods. In the framework of the WHO program «MONICA — PSYCHOSOCIAL» a screening study was performed in 1994, and 657 males aged 25–64 years (mean age — 44,3 ± 0,4 years), the citizens of Novosibirsk were included.Results. The greatest risk of hypertension was observed during the 10-year period in men experiencing stress at home (5-fold increase) and at work (6,8 times higher). Those most at risk of hypertension were the divorced and widowed men, and those with physical labor.

The present study aimed to analyze possible associations of rs7412 and rs429358 of the APOE gene with lipid profile parameters, the risk of myocardial infarction, and death in the mostly white population of Western Siberia (Russia). The study population was selected from a sample surveyed within the framework of the Health, Alcohol and Psychosocial Factors In Eastern Europe (HAPIEE) study (9360 subjects, age 53.8 ± 7.0 years, males/females 50/50). PCR was conducted with fluorescence detection according to the TaqMan principle on a real-time PCR machine. The frequency of a minor allele (C) of rs429358 was 0.13, and the frequency of a minor allele (T) of rs7412 was 0.09. In our study, the woman with the rare ɛ1/ɛ4 genotype had substantial aberrations in blood lipid levels. In Kaplan–Meier curves, statistically significant differences were revealed in the prognosis of survival within the subgroup of females who had a myocardial infarction (p = 0.0006): the prognosis was worse for carriers of the ɛ2/ɛ2 genotype and for ɛ4/ɛ4 carriers. Survival analysis regarding deaths from all causes showed (p = 0.0238) that female carriers of the ɛ2/ɛ4 genotype had a worse prognosis than did carriers of other genotypes. Thus, in the population of Western Siberia (Russia), we confirmed statistically significant associations between rs7412 & rs429358 genotypes and lipid profile parameters.

Aim. To assess the associations between depression and coronary artery disease (CAD) in an open female and male population of a middle-urbanized city of Western Siberia.Material and methods. Two cross-sectional epidemiological studies were carried out on an open population of a middle-urbanized Siberian city among men and women aged 25-64 years old. The prevalenceof CAD was assessed based on standard epidemiological methods. To determine the severity of depression, the algorithms of the WHO program MONICA-Psychosocial were used. The severity of depression was assessed as low, moderate, and high. On the basis of the algorithm, the levels of depression were established: low and moderate levels — no sign, high level — presence of a sign.Results. In an open population of 25-64 years old, a moderately urbanized Siberian city, the prevalence of CAD according to extended and lax epidemiological criteria prevailed in men, while strict epidemiological criteria did not reveal significant differences in the male and female subpopulations. In the female subpopulation, a tendency towards an increase in the prevalence of a high level of depression was revealed due to its predominance in young age groups.It has been shown that the depression increases the probability of detecting CAD in accordance with the expanded epidemiological criteria in men and women by 21,07 and 16,04 times, respectively.Conclusion. When using epidemiological criteria for CAD in the presence of depression, the probability of detecting CAD is higher, both in men and women. At the same time, the highest odds ratios are characteristic for a certain type of CAD, the least — CAD by probable signs.

Одним из важнейших социально-психологических свойств личности является отношение к своему здоровью и его самооценка. В этом контексте наличие стресса в семье при работе экспедиционно-вахтовым методом в условиях Арктического региона приобретает особое значение и негативно влияет на приверженность здоровому образу жизни. ЦЕЛЬ ИССЛЕДОВАНИЯ Определение ассоциаций стресса в семье, параметров отношения к собственному здоровью и его самооценки среди лиц, занятых на промышленных предприятиях нефтегазодобывающего комплекса Арктического региона, в зависимости от стажа работы экспедиционно-вахтовым методом. МАТЕРИАЛ И МЕТОДЫ Объектом исследования является случайная репрезентативная выборка из работников мужского пола, занятых экспедиционно-вахтовой формой труда на промышленном предприятии «ЕВРАКОР» в арктических широтах Тюменского региона. В состав выборки вошли 750 мужчин в возрасте 25—54 лет, отклик составил 82,4%. Оценку стажа работы экспедиционно-вахтовым методом в условиях Арктики проводили по трем параметрам 1) стаж 3 года и менее; 2) стаж 4—9 лет; 3) стаж 10 лет и более. Определение стресса в семье, параметров отношения к своему здоровью и его самооценки осуществляли посредством анализа стандартной анкеты WHO MONICA-MOPSY. РЕЗУЛЬТАТЫ При наличии стресса в семье, независимо от стажа работы в Арктическом регионе, установлено статистически значимое снижение самооценки здоровья среди лиц, занятых экспедиционно-вахтовой формой труда. В группах с длительным стажем работы в условиях Арктики (4—9 лет и ≥10 лет) при наличии стресса в семье выявлено статистически значимое снижение заботы о своем здоровье и снижение числа обращений к врачу при плохом самочувствии, при стаже 10 лет и более отмечена явно недостаточная забота о своем здоровье. При наличии стресса в семье, независимо от стажа работы экспедиционной вахтой в Арктике, установлена низкая ответственность за свое здоровье, при длительном стаже работы в режиме экспедиционной вахты — статистически значимое снижение обращений к врачу. ЗАКЛЮЧЕНИЕ Таким образом, результаты по определению ассоциаций стресса в семье и параметров отношения к здоровью, его самооценки в организованной популяции работников нефтегазодобывающего комплекса в зависимости от стажа работы экспедиционно-вахтовым методом необходимо использовать как весомую часть комплексной профилактической программы на промышленных предприятиях Арктического региона.