Marek Murias

Prof. Marek Murias

Poznan University of Medical Sciences, Poznań, Wielkopolskie, Poland
orcid

Research Focus & Metrics

Academic Career Length

28Years (1999-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

View All Publications
1 January 2012 in Mutation Research - Reviews in Mutation Research
Verified
Journal Article
Closed access
HPHanna Piotrowska
Hanna Piotrowska
MKMalgorzata Kucinska
Malgorzata Kucinska
Marek MuriasMarek Murias
Marek Murias

1 March 2005 in Biochemical Pharmacology
Verified
Journal Article
Closed access
Marek MuriasMarek Murias
Marek Murias
WJWalter Jäger
Walter Jäger
NHNorbert Handler
Norbert Handler
TEThomas Erker
Thomas Erker
ZHZsuzsanna Horvath
Zsuzsanna Horvath
LGLars Gille
Lars Gille

1 November 2004 in Bioorganic & Medicinal Chemistry
Verified
Journal Article
Closed access
Marek MuriasMarek Murias
Marek Murias
NHNorbert Handler
Norbert Handler
TEThomas Erker
Thomas Erker
KPKarin Pleban
Karin Pleban
GEGerhard Ecker
Gerhard Ecker
WJWalter Jäger
Walter Jäger

1 March 2011 in Acta Biomaterialia
Verified
Journal Article
Closed access
MGMalgorzata Geszke
Malgorzata Geszke
Marek MuriasMarek Murias
Marek Murias
Lavinia BalanLavinia Balan
Lavinia Balan
GMGhouti Medjahdi
Ghouti Medjahdi
JKJaroslaw Korczynski
Jaroslaw Korczynski
Raphaël SchneiderRaphaël Schneider
Raphaël Schneider

27 July 2020 in Biomolecules
Verified
Journal Article
Open access
PDF file
PPPaulina Pecyna
Paulina Pecyna
JWJoanna Wargula
Joanna Wargula
Marek MuriasMarek Murias
Marek Murias
MKMalgorzata Kucinska
Malgorzata Kucinska
The concept of a scaffold concerns many aspects at different steps on the drug development path. In medicinal chemistry, the choice of relevant “drug-likeness” scaffold is a starting point for the design of the structure dedicated to specific molecular targets. For many years, the chemical uniqueness of the stilbene structure has inspired scientists from different fields such as chemistry, biology, pharmacy, and medicine. In this review, we present the outstanding potential of the stilbene-based derivatives. Naturally occurring stilbenes, together with powerful synthetic chemistry possibilities, may offer an excellent approach for discovering new structures and identifying their therapeutic targets. With the development of scientific tools, sophisticated equipment, and a better understanding of the disease pathogenesis at the molecular level, the stilbene scaffold has moved innovation in science. This paper mainly focuses on the stilbene-based compounds beyond resveratrol, which are particularly attractive due to their biological activity. Given the “fresh outlook” about different stilbene-based compounds starting from stilbenoids with particular regard to isorhapontigenin and methoxy- and hydroxyl- analogues, the update about the combretastatins, and the very often overlooked and underestimated benzanilide analogues, we present a new story about this remarkable structure.

15 November 2012 in Journal of Materials Chemistry B
Verified
Journal Article
Closed access
PDF file
MGMałgorzata Geszke-Moritz
Małgorzata Geszke-Moritz
HPHanna Piotrowska
Hanna Piotrowska
Marek MuriasMarek Murias
Marek Murias
Lavinia BalanLavinia Balan
Lavinia Balan
MMMichal Moritz
Michal Moritz
Raphaël SchneiderRaphaël Schneider
Raphaël Schneider
Water-dispersible 1-thioglycerol (TG)-capped Mn-doped ZnS quantum dots were prepared in aqueous solution using the nucleation-doping strategy. Using 4% Mn relative to Zn and a Zn(OAc)2/Na2S ratio of 0.9, Mn:ZnS nanocrystals with an average diameter of 3.9 ± 0.5 nm, with pure Mn2+-related photoluminescence (PL) at 585 nm, and with a PL quantum yield of 13.2% were obtained. Transmission electron microscopy, X-ray powder diffraction, electron spin resonance, X-ray photoelectron spectroscopy, UV-visible spectroscopy and spectrofluorometry have been used to characterize the crystal structure, the doping status, and the optical properties of the doped-dots. Folic acid (FA) was linked to TG-capped Mn:ZnS nanocrystals to produce Mn:ZnS@TG-FA nanobioconjugates that were used for targeted in vitro delivery to a human cancer cell line. Folate receptor mediated cellular uptake of FA-functionalized dots is proven via confocal and two-photon imaging.