Fergal O'Brien

Dr. Fergal O'Brien

1. Tissue Engineering Research Group, Department of Anatomy, Royal College of Surgeons in Ireland, 123 St. Stephen's Green, Dublin 2, Ireland
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orcid

Research Focus & Metrics

Academic Career Length

29Years (1998-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 March 2011 in Materials Today
Verified
Journal Article
Open access
Fergal O'BrienFergal O'Brien
Fergal O'Brien


1 February 2005 in Biomaterials
Verified
Journal Article
Closed access
Fergal O'BrienFergal O'Brien
Fergal O'Brien
BHB.A. Harley
B.A. Harley
IYI.V. Yannas
I.V. Yannas
LGL.J. Gibson
L.J. Gibson

1 July 2010 in Cell Adhesion & Migration
Verified
Journal Article
Open access
Ciara MurphyCiara Murphy
Ciara Murphy
Fergal O'BrienFergal O'Brien
Fergal O'Brien
Mean pore size is an essential aspect of scaffolds for tissue-engineering. If pores are too small cells cannot migrate in towards the center of the construct limiting the diffusion of nutrients and...

1 April 2018 in Clinical Microbiology Reviews
Verified
Journal Article
Closed access
NKNicola Kavanagh
Nicola Kavanagh
EREmily J. Ryan
Emily J. Ryan
AWAmro Widaa
Amro Widaa
GSGillian Sexton
Gillian Sexton
JFJerome Fennell
Jerome Fennell
SKSteven W. Kerrigan
Steven W. Kerrigan
SUMMARY: Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism and leads to progressive bone destruction and loss. The most common causative species are the usually commensal staphylococci, withStaphylococcus aureusandStaphylococcus epidermidisresponsible for the majority of cases. Staphylococcal infections are becoming an increasing global concern, partially due to the resistance mechanisms developed by staphylococci to evade the host immune system and antibiotic treatment. In addition to the ability of staphylococci to withstand treatment, surgical intervention in an effort to remove necrotic and infected bone further exacerbates patient impairment. Despite the advances in current health care, osteomyelitis is now a major clinical challenge, with recurrent and persistent infections occurring in approximately 40% of patients. This review aims to provide information about staphylococcus-induced bone infection, covering the clinical presentation and diagnosis of osteomyelitis, pathophysiology and complications of osteomyelitis, and future avenues that are being explored to treat osteomyelitis.

1 April 2019 in Acta Biomaterialia
Verified
Journal Article
Closed access
RSRukmani Sridharan
Rukmani Sridharan
BCBrenton Cavanagh
Brenton Cavanagh
ACAndrew R. Cameron
Andrew R. Cameron
DKDaniel Kelly
Daniel Kelly
Fergal O'BrienFergal O'Brien
Fergal O'Brien