Authors' contributions: Conceived and designed the study: Ting-yun Huang MD and Ching-Kuo Yang MD. Performed the experiments: Ming-Yao Chen MD, PhD. Analyzed the data: Vijesh Kumar Yadav PhD. Bioinformatics: Iat-Hang Fong PhD. Wrote the manuscript: Ting-yun Huang MD and Chi-Tai Yeh MD, PhD. Provided reagents, materials, experimental infrastructure, and administrative oversight: Yih-Giun Cherng MD, PhD. All authors read and approved the final version of the manuscript.