In this work, a method to prepare hybrid amphiphilic block copolymers consisting of biocompatible synthetic glycopolymer with non-degradable backbone and biodegradable poly(amino acid) (PAA) was developed. The glycopolymer, poly(2-deoxy-2-methacrylamido-D-glucose) (PMAG), was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization. Two methods for modifying the terminal dithiobenzoate-group of PMAG was investigated to obtain the macroinitiator bearing a primary aliphatic amino group, which is required for ring-opening polymerization of N-carboxyanhydrides of hydrophobic α-amino acids. The synthesized amphiphilic block copolymers were carefully analyzed using a set of different physico-chemical methods to establish their composition and molecular weight. The developed amphiphilic copolymers tended to self-assemble in nanoparticles of different morphology that depended on the nature of the hydrophobic amino acid present in the copolymer. The hydrodynamic diameter, morphology, and cytotoxicity of polymer particles based on PMAG-b-PAA were evaluated using dynamic light scattering (DLS) and transmission electron microscopy (TEM), as well as CellTiter-Blue (CTB) assay, respectively. The redox-responsive properties of nanoparticles were evaluated in the presence of glutathione taken at different concentrations. Moreover, the encapsulation of paclitaxel into PMAG-b-PAA particles and their cytotoxicity on human lung carcinoma cells (A549) and human breast adenocarcinoma cells (MCF-7) were studied.

Novel macromolecular brushes with a polyimide backbone and diphilic diblock copolymer side chains consisting of a hydrophilic block of poly(methacrylic acid) adjacent to the backbone and the outer...

Multicomponent molecular brushes containing amphiphilic polymer moieties are promising objects of research of macromolecular chemistry. The development of stimulus-responsive systems sensitive to changes in environmental parameters, based on the molecular brushes, opens up new possibilities for their applications in medicine, biochemistry and microelectronics. The review presents the current understanding of the structures of main types of amphiphilic multicomponent brushes, depending on the chemical nature and type of coupling of the backbone and side chains. The approaches to the controlled synthesis of multicomponent molecular brushes of different architecture are analyzed. Self-assembly processes of multicomponent molecular brushes in selective solvents are considered. The bibliography includes 259 references.

The controlled radical polymerization of N, N-dimethylamino-2-ethyl methacrylate on polyimide multicenter macroinitiators under the action of the activating complex of Cu(I) with nitrogen-containing...