Alexis Debut

Prof. Alexis Debut

Universidad de las Fuerzas Armadas ESPE, Sangolquí, Pichincha, Ecuador
orcid

Research Focus & Metrics

Academic Career Length

27Years (2000-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2017 in Saudi Journal of Biological Sciences
Verified
Journal Article
Open access
Brajesh KumarBrajesh Kumar
Brajesh Kumar
KSKumari Smita
Kumari Smita
Luis CumbalLuis Cumbal
Luis Cumbal
Alexis DebutAlexis Debut
Alexis Debut
Green synthesis of nanoparticles using various plant materials opens a new scope for the phytochemist and discourages the use of toxic chemicals. In this article, we report an eco-friendly and low-cost method for the synthesis of silver nanoparticles (AgNPs) using Andean blackberry fruit extracts as both a reducing and capping agent. The green synthesized AgNPs were characterized by various analytical instruments like UV-visible, transmission electron microscopy (TEM), dynamic light scattering (DLS), X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The formation of AgNPs was analyzed by UV-vis spectroscopy at λmax = 435 nm. TEM analysis of AgNPs showed the formation of a crystalline, spherical shape and 12-50 nm size, whereas XRD peaks at 38.04°, 44.06°, 64.34° and 77.17° confirmed the crystalline nature of AgNPs. FTIR analysis was done to identify the functional groups responsible for the synthesis of the AgNPs. Furthermore, it was found that the AgNPs showed good antioxidant efficacy (>78%, 0.1 mM) against 1,1-diphenyl-2-picrylhydrazyl. The process of synthesis is environmentally compatible and the synthesized AgNPs could be a promising candidate for many biomedical applications.

14 July 2000 in Physical Review A
Verified
Journal Article
Closed access
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Alexis DebutAlexis Debut
Alexis Debut
SRStephane Randoux
Stephane Randoux
JZJaouad Zemmouri
Jaouad Zemmouri
The linewidth narrowing observed in Brillouin fiber ring lasers is studied within the framework of the usual three-wave model of stimulated Brillouin scattering. We show that the phase noise of the pump laser is transferred to the emitted Stokes wave after being strongly reduced and smoothed under the combined influence of the acoustic damping and the cavity feedback. We then derive a simple analytical relation connecting the full width at half maximum of the Stokes linewidth to that of the pump laser.

10 March 2022 in PLOS ONE
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Journal Article
Open access
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NHNathaly S. Heredia
Nathaly S. Heredia
Karla VizueteKarla Vizuete
Karla Vizuete
Marco Javier Flores-CaleroMarco Javier Flores-Calero
Marco Javier Flores-Calero
KVKatherine Pazmiño V.
Katherine Pazmiño V.
MPMaría Fernanda Pilaquinga
María Fernanda Pilaquinga
Alexis DebutAlexis Debut
Alexis Debut
Poly(lactic-co-glycolic acid) is one of the most used polymers for drug delivery systems (DDSs). It shows excellent biocompatibility, biodegradability, and allows spatio-temporal control of the release of a drug by altering its chemistry. In spite of this, few formulations have reached the market. To characterize and optimize the drug release process, mathematical models offer a good alternative as they allow interpreting and predicting experimental findings, saving time and money. However, there is no general model that describes all types of drug release of polymeric DDSs. This study aims to perform a statistical comparison of several mathematical models commonly used in order to find which of them best describes the drug release profile from PLGA particles synthesized by nanoprecipitation method. For this purpose, 40 datasets extracted from scientific articles published since 2016 were collected. Each set was fitted by the models: order zero to fifth order polynomials, Korsmeyer-Peppas, Weibull and Hyperbolic Tangent Function. Some data sets had few observations that do not allow to apply statistic test, thus bootstrap resampling technique was performed. Statistic evidence showed that Hyperbolic Tangent Function model is the one that best fit most of the data.

1 September 2014 in Journal of Saudi Chemical Society
Verified
Journal Article
Open access
Brajesh KumarBrajesh Kumar
Brajesh Kumar
KSKumari Smita
Kumari Smita
Luis CumbalLuis Cumbal
Luis Cumbal
Alexis DebutAlexis Debut
Alexis Debut
A simple, efficient, and ecofriendly method has been developed for the exclusive synthesis of iron oxide nanoparticles using an aqueous extract of Passiflora tripartita var. mollissima fruit. Transmission electron microscopy (TEM) and Dynamic Light Scattering (DLS) analysis show that the average particle size of spherical iron oxide nanoparticles is 22.3 ± 3 nm. The synthesized nanocatalyst is highly active for the synthesis of biologically significant 2-arylbenzimidazoles. The reaction was carried out under mild condition with excellent yields. The catalyst is easily separated by magnet and recyclable without significant loss of activity

1 January 2017 in Journal of Saudi Chemical Society
Verified
Journal Article
Open access
Brajesh KumarBrajesh Kumar
Brajesh Kumar
KSKumari Smita
Kumari Smita
Luis CumbalLuis Cumbal
Luis Cumbal
Alexis DebutAlexis Debut
Alexis Debut
YAYolanda Angulo
Yolanda Angulo
Biofabrication of copper oxide nanoparticles (CuO-NPs) of a desired size remains a significant challenge. In this report, CuO-NPs were fabricated by treating 10mM copper nitrate with Andean blackberry fruit (ABF) and leaf (ABL); and evaluated its antioxidant activity. As-prepared NPs characterization were determined by UV–visible spectrophotometry, Dynamic Light Scattering (DLS), transmission electron microscopy (TEM) with selected area electron diffraction (SAED) and X-ray diffraction (XRD) analysis. UV–visible spectroscopy showed an electronic excitonic transition at 250–255nm clearly reveals the formation of ABF and ABL CuO-NPs. DLS analysis demonstrated mean diameter of ABF CuO-NPs (43.3nm) smaller than ABL CuO-NPs (52.5nm). TEM with SAED confirmed the CuO-NPs are spherical and of partial crystalline nature. Furthermore, the antioxidant efficacy of ABF CuO-NPs showed 89.02%, 1mM whereas ABL CuO-NPs 75.92%, 1mM against 1,1-diphenyl-2-picrylhydrazyl. From the results obtained it is suggested that green CuO-NPs could be used effectively in future biomedical concerns

1 August 2016 in Materials Chemistry and Physics
Verified
Journal Article
Closed access
Brajesh KumarBrajesh Kumar
Brajesh Kumar
KSKumari Smita
Kumari Smita
Luis CumbalLuis Cumbal
Luis Cumbal
Alexis DebutAlexis Debut
Alexis Debut
SGSalome Galeas
Salome Galeas
Victor H. GuerreroVictor H. Guerrero
Victor H. Guerrero