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Background In August 2020, Sputnik V was registered as Gam-COVID-Vac by the Russian Ministry of Health, and since December 2020 it has been distributed in 61 countries worldwide. On 25 February 2021, the Republic of San Marino started its vaccination campaign, which includes Sputnik V. Our aim was to describe the adverse events following immunization (AEFIs) with this vaccine through participant-based active surveillance in the country. Methods Beginning from 4 March to 8 April 2021, a nationwide study was conducted on San Marino's population aged 18–89 years who received one or two doses of Sputnik V. E-questionnaire dissemination occurred through e-mails, QR-codes or live/phone interviews ~7 days after the first and second vaccine dose. A descriptive analysis was conducted to quantify AEFI incidence on both occasions, stratifying results by type and severity of symptoms. Findings Mean age of the 2558 vaccine recipients was 66±14 years. First-dose AEFI incidence was 53.3% (systemic reactions at 42.2%), while second-dose AEFI incidence was 66.8% (systemic reactions at 50.4%) (n = 1288). In general, 76.0% of two-dose recipients reported some AEFIs after either vaccine dose, and 2.1% suffered severe reactions; in 60- to 89-year-olds (n = 1021), AEFI incidence was 70.0%, with 53.0% of subjects describing systemic reactions and 0.8% reporting severe symptoms. The most frequent symptoms were local pain, asthenia, headache and joint pain. Interpretation Our results, albeit preliminary, suggest that Sputnik V has a high tolerability profile in the population aged ≥60 years in terms of short-term AEFIs.
Marco Montalti; Giorgia Soldà; Zeno Di Valerio; Aurelia Salussolia; Jacopo Lenzi; Marcello Forcellini; Edoardo Barvas; Susanna Guttmann; Rossella Messina; Elisabetta Poluzzi; Emanuel Raschi; Rossano Riccardi; Maria Pia Fantini; Giusy La Fauci; Davide Gori. ROCCA observational study: Early results on safety of Sputnik V vaccine (Gam-COVID-Vac) in the Republic of San Marino using active surveillance. EClinicalMedicine 2021, 38, 1 .
AMA StyleMarco Montalti, Giorgia Soldà, Zeno Di Valerio, Aurelia Salussolia, Jacopo Lenzi, Marcello Forcellini, Edoardo Barvas, Susanna Guttmann, Rossella Messina, Elisabetta Poluzzi, Emanuel Raschi, Rossano Riccardi, Maria Pia Fantini, Giusy La Fauci, Davide Gori. ROCCA observational study: Early results on safety of Sputnik V vaccine (Gam-COVID-Vac) in the Republic of San Marino using active surveillance. EClinicalMedicine. 2021; 38 ():1.
Chicago/Turabian StyleMarco Montalti; Giorgia Soldà; Zeno Di Valerio; Aurelia Salussolia; Jacopo Lenzi; Marcello Forcellini; Edoardo Barvas; Susanna Guttmann; Rossella Messina; Elisabetta Poluzzi; Emanuel Raschi; Rossano Riccardi; Maria Pia Fantini; Giusy La Fauci; Davide Gori. 2021. "ROCCA observational study: Early results on safety of Sputnik V vaccine (Gam-COVID-Vac) in the Republic of San Marino using active surveillance." EClinicalMedicine 38, no. : 1.
In 2019, vaccine hesitancy (VH), defined by the SAGE working group as “delay in acceptance or refusal of vaccination despite availability of vaccination services”
Davide Gori; Marco Montalti; Federica Guaraldi. Mass Immunization and Vaccine Hesitancy in Children and Their Families: A Long and Winding Road Ahead to Address without a Second Thought. Vaccines 2021, 9, 752 .
AMA StyleDavide Gori, Marco Montalti, Federica Guaraldi. Mass Immunization and Vaccine Hesitancy in Children and Their Families: A Long and Winding Road Ahead to Address without a Second Thought. Vaccines. 2021; 9 (7):752.
Chicago/Turabian StyleDavide Gori; Marco Montalti; Federica Guaraldi. 2021. "Mass Immunization and Vaccine Hesitancy in Children and Their Families: A Long and Winding Road Ahead to Address without a Second Thought." Vaccines 9, no. 7: 752.
Vaccine hesitancy (VH) has been identified as one of the major health concerns of our time by the World Health Organization. It may prove especially detrimental in the light of the ongoing SARS-CoV-2 pandemic, as vaccination campaigns still represent the primary strategy against the detrimental consequences of the pandemic. Among patients suffering from type 2 diabetes mellitus (DB), who are particularly vulnerable to COVID-19, VH might represent an even more serious threat. Therefore, our study focuses on identifying potential determinants of VH among patients with type 2 diabetes. Study participants (n = 1176) filled in a two-section online self-administered questionnaire, answering questions regarding demographic and anamnestic data, as well as their intention to accept any vaccination against COVID-19. Some possible reasons underlying VH were investigated as well. An overall hesitancy rate of 14.2% was registered. Data showed how older age, male gender, higher education level, and having been vaccinated for seasonal influenza in 2020–2021 were associated with a significantly higher propensity to receive the COVID-19 vaccine. On the contrary, having experienced adverse effects following past vaccinations was a negative predictor. In addition to confirming an array of predictors of VH, we found a worryingly high prevalence of VH among diabetics, who have been shown to be particularly exposed to severe COVID-19 and death. These findings may be useful in planning targeted action toward acceptance improvement and enhancing the efficacy of vaccination campaigns.
Federica Guaraldi; Marco Montalti; Zeno Di Valerio; Edoardo Mannucci; Besmir Nreu; Matteo Monami; Davide Gori. Rate and Predictors of Hesitancy toward SARS-CoV-2 Vaccine among Type 2 Diabetic Patients: Results from an Italian Survey. Vaccines 2021, 9, 460 .
AMA StyleFederica Guaraldi, Marco Montalti, Zeno Di Valerio, Edoardo Mannucci, Besmir Nreu, Matteo Monami, Davide Gori. Rate and Predictors of Hesitancy toward SARS-CoV-2 Vaccine among Type 2 Diabetic Patients: Results from an Italian Survey. Vaccines. 2021; 9 (5):460.
Chicago/Turabian StyleFederica Guaraldi; Marco Montalti; Zeno Di Valerio; Edoardo Mannucci; Besmir Nreu; Matteo Monami; Davide Gori. 2021. "Rate and Predictors of Hesitancy toward SARS-CoV-2 Vaccine among Type 2 Diabetic Patients: Results from an Italian Survey." Vaccines 9, no. 5: 460.
In March 2021, the coronavirus disease 2019 (COVID-19) pandemic still poses a threat to the global population, and is a public health challenge that needs to be overcome. Now more than ever, action is needed to tackle vaccine hesitancy, especially in light of the availability of effective and safe vaccines. A cross-sectional online survey was carried out on a representative random sample of 1011 citizens from the Emilia-Romagna region, in Italy, in January 2021. The questionnaire collected information on socio-demographics, comorbidities, past vaccination refusal, COVID-19-related experiences, risk perception of infection, and likelihood to accept COVID-19 vaccination. Multiple logistic regression analyses and classification tree analyses were performed to identify significant predictors of vaccine hesitancy and to distinguish groups with different levels of hesitancy. Overall, 31.1% of the sample reported hesitancy. Past vaccination refusal was the key discriminating variable followed by perceived risk of infection. Other significant predictors of hesitancy were: ages between 35 and 54 years, female gender, low educational level, low income, and absence of comorbidities. The most common concerns about the COVID-19 vaccine involved safety (54%) and efficacy (27%). Studying the main determinants of vaccine hesitancy can help with targeting vaccination strategies, in order to gain widespread acceptance—a key path to ensure a rapid way out of the current pandemic emergency.
Chiara Reno; Elisa Maietti; Maria Fantini; Elena Savoia; Lamberto Manzoli; Marco Montalti; Davide Gori. Enhancing COVID-19 Vaccines Acceptance: Results from a Survey on Vaccine Hesitancy in Northern Italy. Vaccines 2021, 9, 378 .
AMA StyleChiara Reno, Elisa Maietti, Maria Fantini, Elena Savoia, Lamberto Manzoli, Marco Montalti, Davide Gori. Enhancing COVID-19 Vaccines Acceptance: Results from a Survey on Vaccine Hesitancy in Northern Italy. Vaccines. 2021; 9 (4):378.
Chicago/Turabian StyleChiara Reno; Elisa Maietti; Maria Fantini; Elena Savoia; Lamberto Manzoli; Marco Montalti; Davide Gori. 2021. "Enhancing COVID-19 Vaccines Acceptance: Results from a Survey on Vaccine Hesitancy in Northern Italy." Vaccines 9, no. 4: 378.
In the near future, COVID-19 vaccine efficacy trials in larger cohorts may offer the possibility to implement child and adolescent vaccination. The opening of the vaccination for these strata may play a key role in order to limit virus circulation, infection spreading towards the most vulnerable subjects, and plan safe school reopening. Vaccine hesitancy (VH) could limit the ability to reach the coverage threshold required to ensure herd immunity. The aim of this study was to investigate the prevalence and determinants of VH among parents/guardians toward a potentially available COVID-19 vaccination for children and adolescents. An online survey was performed in parents/guardians of children aged <18 years old, living in Bologna. Overall, 5054 questionnaires were collected. A vast majority (60.4%) of the parents/guardians were inclined to vaccinate, while 29.6% were still considering the opportunity, and 9.9% were hesitant. Highest vaccine hesitancy rates were detected in female parents/guardians of children aged 6–10 years, ≤29 years old, with low educational level, relying on information found in the web/social media, and disliking mandatory vaccination policies. Although preliminary, these data could help in designing target strategies to implement adherence to a vaccination campaign, with special regard to web-based information.
Marco Montalti; Flavia Rallo; Federica Guaraldi; Lapo Bartoli; Giulia Po; Michela Stillo; Paola Perrone; Lorena Squillace; Laura Dallolio; Paolo Pandolfi; Davide Resi; Maria Pia Fantini; Chiara Reno; Davide Gori. Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy. Vaccines 2021, 9, 366 .
AMA StyleMarco Montalti, Flavia Rallo, Federica Guaraldi, Lapo Bartoli, Giulia Po, Michela Stillo, Paola Perrone, Lorena Squillace, Laura Dallolio, Paolo Pandolfi, Davide Resi, Maria Pia Fantini, Chiara Reno, Davide Gori. Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy. Vaccines. 2021; 9 (4):366.
Chicago/Turabian StyleMarco Montalti; Flavia Rallo; Federica Guaraldi; Lapo Bartoli; Giulia Po; Michela Stillo; Paola Perrone; Lorena Squillace; Laura Dallolio; Paolo Pandolfi; Davide Resi; Maria Pia Fantini; Chiara Reno; Davide Gori. 2021. "Would Parents Get Their Children Vaccinated Against SARS-CoV-2? Rate and Predictors of Vaccine Hesitancy According to a Survey over 5000 Families from Bologna, Italy." Vaccines 9, no. 4: 366.
Background: Health-related quality of life (HRQoL) in childhood is a multidimensional construct with many sub dimensions of subjective experience, including physical activity (PA), psychological well-being, social interaction, and school performance, that represents a fundamental health outcome to assess a child’s physical and psycho-social functioning. Our study aims to explore the potential predictors of children’s health-related quality of life, using a convenience sample from the Imola Active Break Study (I-MOVE), considering demographic, anthropometric measures, PA level measured by Actigraph accelerometers, parent-reported/self-reported HRQoL, and body image. Methods: A cross-sectional analysis was conducted among 151 primary school children in Italy. HRQoL was assessed using the Italian version 4.0 of the Paediatric Quality of Life (PedsQL) questionnaire. Results: Children who spent more time partaking in moderate PA were associated with a higher total PedsQL score (p < 0.03). Mother’s body mass index (BMI) was the only variable statistically significant associated with the physical health domain of PedsQL. Parent’s proxy-report perception concerning children’s psychosocial health was statistically relevant. The children’s gender, age, and BMI had no association with any of the HRQoL outcomes. Discussion: Parent proxy-report psychosocial health and mother’s BMI should be considered as predictors of HRQoL for the psychosocial and physical domain. PA should be implemented in order to improve the HRQoL of primary school children.
Alice Masini; Davide Gori; Sofia Marini; Marcello Lanari; Susan Scrimaglia; Francesco Esposito; Francesco Campa; Alessia Grigoletto; Andrea Ceciliani; Stefania Toselli; Laura Dallolio. The Determinants of Health-Related Quality of Life in a Sample of Primary School Children: A Cross-Sectional Analysis. International Journal of Environmental Research and Public Health 2021, 18, 3251 .
AMA StyleAlice Masini, Davide Gori, Sofia Marini, Marcello Lanari, Susan Scrimaglia, Francesco Esposito, Francesco Campa, Alessia Grigoletto, Andrea Ceciliani, Stefania Toselli, Laura Dallolio. The Determinants of Health-Related Quality of Life in a Sample of Primary School Children: A Cross-Sectional Analysis. International Journal of Environmental Research and Public Health. 2021; 18 (6):3251.
Chicago/Turabian StyleAlice Masini; Davide Gori; Sofia Marini; Marcello Lanari; Susan Scrimaglia; Francesco Esposito; Francesco Campa; Alessia Grigoletto; Andrea Ceciliani; Stefania Toselli; Laura Dallolio. 2021. "The Determinants of Health-Related Quality of Life in a Sample of Primary School Children: A Cross-Sectional Analysis." International Journal of Environmental Research and Public Health 18, no. 6: 3251.
This systematic review aimed to investigate the type of physical activity carried out in green urban spaces by the adult population and to value its impact on the population’s health. Additionally, another purpose was to examine if the presence of outdoor gyms in green urban spaces can promote participation in physical activity among adults. Searches of electronic databases, with no time restrictions and up to June 2020, resulted in 10 studies meeting the inclusion criteria. A quantitative assessment is reported as effect size. Many people practiced walking activity as a workout, which showed improvements in health. Walking is the most popular type of training due to its easy accessibility and it not requiring equipment or special skills. Outdoor fitness equipment has been installed in an increasing number of parks and has become very popular worldwide. Further, outdoor fitness equipment provides free access to fitness training and seems to promote physical activity in healthy adults. However, other studies about outdoor fitness equipment efficiency are needed. People living near to equipped areas are more likely to perform outdoor fitness than those who live further away. The most common training programs performed in green urban spaces included exercises with free and easy access, able to promote physical health and perception.
Alessia Grigoletto; Mario Mauro; Pasqualino Maietta Latessa; Vincenzo Iannuzzi; Davide Gori; Francesco Campa; Gianpiero Greco; Stefania Toselli. Impact of Different Types of Physical Activity in Green Urban Space on Adult Health and Behaviors: A Systematic Review. European Journal of Investigation in Health, Psychology and Education 2021, 11, 263 -275.
AMA StyleAlessia Grigoletto, Mario Mauro, Pasqualino Maietta Latessa, Vincenzo Iannuzzi, Davide Gori, Francesco Campa, Gianpiero Greco, Stefania Toselli. Impact of Different Types of Physical Activity in Green Urban Space on Adult Health and Behaviors: A Systematic Review. European Journal of Investigation in Health, Psychology and Education. 2021; 11 (1):263-275.
Chicago/Turabian StyleAlessia Grigoletto; Mario Mauro; Pasqualino Maietta Latessa; Vincenzo Iannuzzi; Davide Gori; Francesco Campa; Gianpiero Greco; Stefania Toselli. 2021. "Impact of Different Types of Physical Activity in Green Urban Space on Adult Health and Behaviors: A Systematic Review." European Journal of Investigation in Health, Psychology and Education 11, no. 1: 263-275.
While the SARS-CoV-2 pandemic continues to strike and collect its death toll throughout the globe, as of 31 January 2021, the vaccine candidates worldwide were 292, of which 70 were in clinical testing. Several vaccines have been approved worldwide, and in particular, three have been so far authorized for use in the EU. Vaccination can be, in fact, an efficient way to mitigate the devastating effect of the pandemic and offer protection to some vulnerable strata of the population (i.e., the elderly) and reduce the social and economic burden of the current crisis. Regardless, a question is still open: after vaccination availability for the public, will vaccination campaigns be effective in reaching all the strata and a sufficient number of people in order to guarantee herd immunity? In other words: after we have it, will we be able to use it? Following the trends in vaccine hesitancy in recent years, there is a growing distrust of COVID-19 vaccinations. In addition, the online context and competition between pro- and anti-vaxxers show a trend in which anti-vaccination movements tend to capture the attention of those who are hesitant. Describing this context and analyzing its possible causes, what interventions or strategies could be effective to reduce COVID-19 vaccine hesitancy? Will social media trend analysis be helpful in trying to solve this complex issue? Are there perspectives for an efficient implementation of COVID-19 vaccination coverage as well as for all the other vaccinations?
Davide Gori; Chiara Reno; Daniel Remondini; Francesco Durazzi; Maria Fantini. Are We Ready for the Arrival of the New COVID-19 Vaccinations? Great Promises and Unknown Challenges Still to Come. Vaccines 2021, 9, 173 .
AMA StyleDavide Gori, Chiara Reno, Daniel Remondini, Francesco Durazzi, Maria Fantini. Are We Ready for the Arrival of the New COVID-19 Vaccinations? Great Promises and Unknown Challenges Still to Come. Vaccines. 2021; 9 (2):173.
Chicago/Turabian StyleDavide Gori; Chiara Reno; Daniel Remondini; Francesco Durazzi; Maria Fantini. 2021. "Are We Ready for the Arrival of the New COVID-19 Vaccinations? Great Promises and Unknown Challenges Still to Come." Vaccines 9, no. 2: 173.
The disruption of gut microbiota eubiosis has been linked to major complications in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Various strategies have been developed to reduce dysbiosis and related complications. Fecal microbiota transplantation (FMT) consists of the infusion of fecal matter from a healthy donor to restore impaired intestinal homeostasis, and could be applied in the allo-HSCT setting. We conducted a systematic review of studies addressing the use of FMT in allo-HSCT patients. In the 23 papers included in the qualitative synthesis, FMT was used for the treatment of recurrent Clostridioides difficile infections or as a therapeutic strategy for steroid-resistant gut aGvHD. FMT was also performed with a preventive aim (e.g., to decolonize from antibiotic-resistant bacteria). Additional knowledge on the biological mechanisms underlying clinical findings is needed in order to employ FMT in clinical practice. There is also concern regarding the administration of microbial consortia in immune-compromised patients with altered gut permeability. Therefore, the safety profile and efficacy of the procedure must be determined to better assess the role of FMT in allo-HSCT recipients.
Andrea Pession; Daniele Zama; Edoardo Muratore; Davide Leardini; Davide Gori; Federica Guaraldi; Arcangelo Prete; Silvia Turroni; Patrizia Brigidi; Riccardo Masetti. Fecal Microbiota Transplantation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review. Journal of Personalized Medicine 2021, 11, 100 .
AMA StyleAndrea Pession, Daniele Zama, Edoardo Muratore, Davide Leardini, Davide Gori, Federica Guaraldi, Arcangelo Prete, Silvia Turroni, Patrizia Brigidi, Riccardo Masetti. Fecal Microbiota Transplantation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review. Journal of Personalized Medicine. 2021; 11 (2):100.
Chicago/Turabian StyleAndrea Pession; Daniele Zama; Edoardo Muratore; Davide Leardini; Davide Gori; Federica Guaraldi; Arcangelo Prete; Silvia Turroni; Patrizia Brigidi; Riccardo Masetti. 2021. "Fecal Microbiota Transplantation in Allogeneic Hematopoietic Stem Cell Transplantation Recipients: A Systematic Review." Journal of Personalized Medicine 11, no. 2: 100.
Background: Recent evidence supports a role of probiotics in preventing necrotizing enterocolitis (NEC) in preterm infants. Methods: A systematic review and network meta-analysis of randomized controlled trials (RCTs) on the role of probiotics in preventing NEC in preterm infants, focusing on the differential effect of type of feeding, was performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A random-effects model was used; a subgroup analysis on exclusively human milk (HM)-fed infants vs. infants receiving formula (alone or with HM) was performed. Results: Fifty-one trials were included (10,664 infants, 29 probiotic interventions); 31 studies (19 different probiotic regimens) were suitable for subgroup analysis according to feeding. In the overall analysis, Lactobacillus acidophilus LB revealed the most promising effect for reducing NEC risk (odds ratio (OR), 0.03; 95% credible intervals (CrIs), 0.00–0.21). The subgroup analysis showed that Bifidobacterium lactis Bb-12/B94 was associated with a reduced risk of NEC stage ≥2 in both feeding type populations, with a discrepancy in the relative effect size in favour of exclusively HM-fed infants (OR 0.04; 95% CrIs B. lactis Bb-12/B94 could reduce NEC risk with a different size effect according to feeding type. Of note, most probiotic strains are evaluated in few trials and relatively small populations, and outcome data according to feeding type are not available for all RCTs. Further trials are needed to confirm the present findings.
Isadora Beghetti; Davide Panizza; Jacopo Lenzi; Davide Gori; Silvia Martini; Luigi Corvaglia; Arianna Aceti. Probiotics for Preventing Necrotizing Enterocolitis in Preterm Infants: A Network Meta-Analysis. Nutrients 2021, 13, 192 .
AMA StyleIsadora Beghetti, Davide Panizza, Jacopo Lenzi, Davide Gori, Silvia Martini, Luigi Corvaglia, Arianna Aceti. Probiotics for Preventing Necrotizing Enterocolitis in Preterm Infants: A Network Meta-Analysis. Nutrients. 2021; 13 (1):192.
Chicago/Turabian StyleIsadora Beghetti; Davide Panizza; Jacopo Lenzi; Davide Gori; Silvia Martini; Luigi Corvaglia; Arianna Aceti. 2021. "Probiotics for Preventing Necrotizing Enterocolitis in Preterm Infants: A Network Meta-Analysis." Nutrients 13, no. 1: 192.
Testing represents one of the main pillars of public health response to SARS-CoV-2/COVID-19 pandemic. This paper shows how accuracy and utility of testing programs depend not just on the type of tests, but on the context as well. We describe the testing methods that have been developed and the possible testing strategies; then, we focus on two possible methods of population-wide testing, i.e., pooled testing and testing with rapid antigen tests. We show the accuracy of split-pooling method and how, in different pre-test probability scenarios, the positive and negative predictive values vary using rapid antigen tests. Split-pooling, followed by retesting of negative results, shows a higher sensitivity than individual testing and requires fewer tests. In case of low pre-test probability, a negative result with antigen test could allow to rule out the infection, while, in case of a positive result, a confirmatory molecular test would be necessary. Test performance alone is not enough to properly choose which test to use; goals and context of the testing program are essential. We advocate the use of pooled strategies when planning population-wide screening, and the weekly use of rapid tests for close periodic monitoring in low-prevalence populations. (www.actabiomedica.it)
Chiara Reno; Jacopo Lenzi; Davide Golinelli; Davide Gori; Carlo Signorelli; John Kraemer; Michael A. Stoto; Elisa Avitabile; Maria Paola Landini; Tiziana Lazzarotto; Maria Carla Re; Paola Rucci; Gloria Taliani; Davide Trerè; Caterina Vocale; Maria Pia Fantini. SARS-CoV-2/COVID-19 Testing: The Tower of Babel. 2020, 91, e2020144 .
AMA StyleChiara Reno, Jacopo Lenzi, Davide Golinelli, Davide Gori, Carlo Signorelli, John Kraemer, Michael A. Stoto, Elisa Avitabile, Maria Paola Landini, Tiziana Lazzarotto, Maria Carla Re, Paola Rucci, Gloria Taliani, Davide Trerè, Caterina Vocale, Maria Pia Fantini. SARS-CoV-2/COVID-19 Testing: The Tower of Babel. . 2020; 91 (4):e2020144.
Chicago/Turabian StyleChiara Reno; Jacopo Lenzi; Davide Golinelli; Davide Gori; Carlo Signorelli; John Kraemer; Michael A. Stoto; Elisa Avitabile; Maria Paola Landini; Tiziana Lazzarotto; Maria Carla Re; Paola Rucci; Gloria Taliani; Davide Trerè; Caterina Vocale; Maria Pia Fantini. 2020. "SARS-CoV-2/COVID-19 Testing: The Tower of Babel." 91, no. 4: e2020144.
Background: Children and adolescents should perform, according to the World Health Organization guidelines, at least 60 min of moderate-to-vigorous physical activity per-day in order to avoid the risk of metabolic and cardiovascular diseases. The school represents a fundamental setting to conduct interventions to promote physical activity (PA) and contrast sedentary behaviors. Active breaks (ABs), bouts of 10 min of PA conducted inside the classroom, seem to be a good strategy to promote PA and improve classroom behavior. The aim of this study protocol is to describe the design and the assessment of the Imola Active Breaks I-MOVE study. Methods: The I-MOVE study is a school-based intervention trial, with a quasi-experimental design, performed in a primary school. It involves one experimental-group performing the intervention, focused on ABs, and one control-group. Nine main outcomes are evaluated: PA and sedentary behaviors; health related fitness; motor control development; dietary patterns; anthropometric evaluation; sociodemographic determinants; cognitive function; time-on-task behavior and quality of life. Conclusions: Results from the I-MOVE study will help to clarify the effects of incorporating ABs in the Italian school curriculum as a new public health strategy and an innovative school model oriented to the well-being of children and teachers for the best quality of school life.
Alice Masini; Marcello Lanari; Sofia Marini; Alessia Tessari; Stefania Toselli; Rita Stagni; Maria Cristina Bisi; Laura Bragonzoni; Davide Gori; Alessandra Sansavini; Andrea Ceciliani; Laura Dallolio. A Multiple Targeted Research Protocol for a Quasi-Experimental Trial in Primary School Children Based on an Active Break Intervention: The Imola Active Breaks (I-MOVE) Study. International Journal of Environmental Research and Public Health 2020, 17, 6123 .
AMA StyleAlice Masini, Marcello Lanari, Sofia Marini, Alessia Tessari, Stefania Toselli, Rita Stagni, Maria Cristina Bisi, Laura Bragonzoni, Davide Gori, Alessandra Sansavini, Andrea Ceciliani, Laura Dallolio. A Multiple Targeted Research Protocol for a Quasi-Experimental Trial in Primary School Children Based on an Active Break Intervention: The Imola Active Breaks (I-MOVE) Study. International Journal of Environmental Research and Public Health. 2020; 17 (17):6123.
Chicago/Turabian StyleAlice Masini; Marcello Lanari; Sofia Marini; Alessia Tessari; Stefania Toselli; Rita Stagni; Maria Cristina Bisi; Laura Bragonzoni; Davide Gori; Alessandra Sansavini; Andrea Ceciliani; Laura Dallolio. 2020. "A Multiple Targeted Research Protocol for a Quasi-Experimental Trial in Primary School Children Based on an Active Break Intervention: The Imola Active Breaks (I-MOVE) Study." International Journal of Environmental Research and Public Health 17, no. 17: 6123.
The outbreak of coronavirus disease 2019 (COVID-19) was identified in Wuhan, China, in December 2019. As of 17 April 2020, more than 2 million cases of COVID-19 have been reported worldwide. Northern Italy is one of the world’s centers of active coronavirus cases. In this study, we predicted the spread of COVID-19 and its burden on hospital care under different conditions of social distancing in Lombardy and Emilia-Romagna, the two regions of Italy most affected by the epidemic. To do this, we used a Susceptible-Exposed-Infectious-Recovered (SEIR) deterministic model, which encompasses compartments relevant to public health interventions such as quarantine. A new compartment
Chiara Reno; Jacopo Lenzi; Antonio Navarra; Eleonora Barelli; Davide Gori; Alessandro Lanza; Riccardo Valentini; Biao Tang; Maria Pia Fantini. Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model. Journal of Clinical Medicine 2020, 9, 1492 .
AMA StyleChiara Reno, Jacopo Lenzi, Antonio Navarra, Eleonora Barelli, Davide Gori, Alessandro Lanza, Riccardo Valentini, Biao Tang, Maria Pia Fantini. Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model. Journal of Clinical Medicine. 2020; 9 (5):1492.
Chicago/Turabian StyleChiara Reno; Jacopo Lenzi; Antonio Navarra; Eleonora Barelli; Davide Gori; Alessandro Lanza; Riccardo Valentini; Biao Tang; Maria Pia Fantini. 2020. "Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model." Journal of Clinical Medicine 9, no. 5: 1492.
This review aimed to meta-analyze evidence of efficacy and safety of one single dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis. Database searches of MEDLINE (PubMed), Scopus (Elsevier), Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov up to November 2019 were performed. Only randomized clinical trials versus placebo were considered. Fixed and random effect models were used for the analyses of pooled data. Thirteen randomized clinical trials (2146 patients) were finally included. One single dose of ondansetron showed to produce (1) higher chance of vomiting cessation within 8 h (RR 1.41, 95% CI 1.19-1.68; low-quality evidence); (2) lower chances of oral rehydration therapy failure (RR 0.43, 95% CI 0.34-0.55; high-quality evidence), intravenous hydration needs (RR 0.44, 95% CI 0.34-0.57; high-quality evidence), and hospitalization rates within 8 h (RR 0.49, 95% CI 0.32-0.75; high-quality evidence); and (3) no statistically significant differences in return visits to emergency department (RR 1.14, 95% CI 0.74-1.76; high-quality evidence) compared with placebo. Further studies are necessary to better assess long term efficacy and safety of ondansetron in this context.Conclusions: Mixed evidence was found via few studies about the efficacy and safety of a single dose of ondansetron in the pediatric population.What is known:• Ondansetron use for vomiting in pediatric acute gastroenteritis is increasing worldwide.• Actual convictions come from studies evaluating one and more than one dose of the drug.What is new:• This is the first review to collect data about the effects of one single dose of ondansetron on strong and temporally homogeneous clinical outcomes.• This study supports the use of one dose of ondansetron in pediatric acute gastroenteritis.• Further studies are necessary to assess its long-term efficacy and safety.
Francesco Fugetto; Emanuele Filice; Carlotta Biagi; Luca Pierantoni; Davide Gori; Marcello Lanari. Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis—an updated systematic review and meta-analysis. European Journal of Pediatrics 2020, 179, 1007 -1016.
AMA StyleFrancesco Fugetto, Emanuele Filice, Carlotta Biagi, Luca Pierantoni, Davide Gori, Marcello Lanari. Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis—an updated systematic review and meta-analysis. European Journal of Pediatrics. 2020; 179 (7):1007-1016.
Chicago/Turabian StyleFrancesco Fugetto; Emanuele Filice; Carlotta Biagi; Luca Pierantoni; Davide Gori; Marcello Lanari. 2020. "Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis—an updated systematic review and meta-analysis." European Journal of Pediatrics 179, no. 7: 1007-1016.
ObjectivesDuring the course of the Novel Coronavirus (SARS-CoV-2) pandemic, Italy has reported one of the highest number of infections. Nearly ten percent of reported coronavirus infections in Italy occurred in healthcare workers. This study aimed to understand physicians’ access to personal protective equipment (PPE) and to information about their use, risk perception and strategies adopted to prevent contracting the infection.MethodsWe undertook a cross-sectional, online self-reported survey implemented between March 31 and April 5 2020 of Italian physicians.ResultsResponses were received from 529 physicians, only 13% of which reported to have access to PPE every time they need them. Approximately half of the physicians reported that the information received about the use of PPE was either clear (47%) or complete (54%). Risk perception about contracting the infection was influenced by receiving adequate information on the use of PPE. Access to adequate information on the use of PPE was associated with better ability to perform donning and doffing procedures [OR=2.2 95% C.I. 1.7–2.8] and reduced perception of risk [OR=0.5, 95% C.I. 0.4–0.6].ConclusionsResults from this rapid survey indicate that while ramping up supplies on PPE for healthcare workers is certainly of mandatory importance, adequate training and clear instructions are just as important.
Elena Savoia; Giorgia Argentini; Davide Gori; Elena Neri; Rachael Piltch-Loeb; Maria Pia Fantini. Factors Associated with Access and Use of PPE during COVID-19: A Cross-sectional Study of Italian Physicians. 2020, 1 .
AMA StyleElena Savoia, Giorgia Argentini, Davide Gori, Elena Neri, Rachael Piltch-Loeb, Maria Pia Fantini. Factors Associated with Access and Use of PPE during COVID-19: A Cross-sectional Study of Italian Physicians. . 2020; ():1.
Chicago/Turabian StyleElena Savoia; Giorgia Argentini; Davide Gori; Elena Neri; Rachael Piltch-Loeb; Maria Pia Fantini. 2020. "Factors Associated with Access and Use of PPE during COVID-19: A Cross-sectional Study of Italian Physicians." , no. : 1.
The outbreak of coronavirus disease 2019 (COVID-19) was identified in Wuhan, China, in December 2019. As of April 17, 2020, more than 2 million cases of COVID-19 have been reported worldwide. Northern Italy is one of the world’s centers of active coronavirus cases. In this study, we predicted the spread of COVID-19 and its burden on hospital care under different conditions of social distancing in Lombardy and Emilia-Romagna, the two regions of Italy most affected by the epidemic. To do this, we used a Susceptible-Exposed-Infectious-Recovered (SEIR) deterministic model, which encompasses compartments relevant to public health interventions such as quarantine. A new compartment L was added to the model for isolated infected population, i.e., individuals tested positives that do not need hospital care. We found that in Lombardy restrictive containment measures should be prolonged at least until early July to avoid a resurgence of hospitalizations; on the other hand, in Emilia-Romagna the number of hospitalized cases could be kept under a reasonable amount with a higher contact rate. Our results suggest that territory-specific forecasts under different scenarios are crucial to enhance or take new containment measures during the epidemic.
Chiara Reno; Jacopo Lenzi; Antonio Navarra; Eleonora Barelli; Davide Gori; Alessandro Lanza; Riccardo Valentini; Biao Tang; Maria Pia Fantini. Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model. 2020, 1 .
AMA StyleChiara Reno, Jacopo Lenzi, Antonio Navarra, Eleonora Barelli, Davide Gori, Alessandro Lanza, Riccardo Valentini, Biao Tang, Maria Pia Fantini. Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model. . 2020; ():1.
Chicago/Turabian StyleChiara Reno; Jacopo Lenzi; Antonio Navarra; Eleonora Barelli; Davide Gori; Alessandro Lanza; Riccardo Valentini; Biao Tang; Maria Pia Fantini. 2020. "Forecasting COVID-19-Associated Hospitalizations under Different Levels of Social Distancing in Lombardy and Emilia-Romagna, Northern Italy: Results from an Extended SEIR Compartmental Model." , no. : 1.
Children of migrant families are known to be at a higher risk of diet-related morbidities due to complex variables including food insecurity, cultural and religious beliefs, and sociodemographic factors like ethnicity, socioeconomic status, and education. Several studies have assessed the presence of specific diseases related to dietary issues in migrant children. This systematic review aims to highlight the existing body of work on nutritional deficiencies in the specific vulnerable pediatric population of immigrants. Refugees were intentionally excluded because of fundamental differences between the two groups including the reasons for migration and health status at the time of arrival. A total of 29 papers were included and assessed for quality. Most of them described a strong correlation between obesity and migration. A high prevalence of stunting, early childhood caries, iron and vitamin D deficiency was also reported, but the studies were few and heterogeneous. Food insecurity and acculturation were found important social factors (nevertheless with inconclusive results) influencing dietary habits and contributing to the development of morbidities such as obesity and other metabolic disorders, which can cause progressive unsustainability of health systems. Public health screening for diet-related diseases in migrant children may be implemented. Educational programs to improve children’s diet and promote healthy-living behaviors as a form of socioeconomic investment for the health of the new generations may also be considered.
Arianna Dondi; Valentina Piccinno; Francesca Morigi; Sugitha Sureshkumar; Davide Gori; Marcello Lanari. Food Insecurity and Major Diet-Related Morbidities in Migrating Children: A Systematic Review. Nutrients 2020, 12, 379 .
AMA StyleArianna Dondi, Valentina Piccinno, Francesca Morigi, Sugitha Sureshkumar, Davide Gori, Marcello Lanari. Food Insecurity and Major Diet-Related Morbidities in Migrating Children: A Systematic Review. Nutrients. 2020; 12 (2):379.
Chicago/Turabian StyleArianna Dondi; Valentina Piccinno; Francesca Morigi; Sugitha Sureshkumar; Davide Gori; Marcello Lanari. 2020. "Food Insecurity and Major Diet-Related Morbidities in Migrating Children: A Systematic Review." Nutrients 12, no. 2: 379.
Background: Vaccine hesitancy has increased worldwide, leading to reduction in vaccination coverage rates. In particular, reduction in the coverage for the trivalent Measles-Mumps-Rubella vaccine has led to an increase of measles cases. The aim of this study is to analyze the coverage rates for the MMR vaccine in the Emilia-Romagna Region (RER) and Sicily Region (SR) between 2009 and 2018, and to correlate any significant change to index events which could have modified the trend of vaccination rates. Methods: Official aggregate data on vaccination coverage at 24 months provided by the RER and the SR were analyzed through trend analysis and related to important index events. Results: The two regions showed similar results; both achieved the lowest coverage rates in 2015 and both showed an increase in the rates after the introduction of mandatory vaccinations for access to schools. In 2018, both reached the starting point before the decrease. Conclusions: Our results confirm the effectiveness of legislative coercive measures in favor of vaccination. A potential decrease in the coverage rates may be observed as a result of an attenuation of the positive effects of coercive measures over time. It is thus necessary to combine these measures together with information campaigns and political initiatives at different levels (i.e., national, regional).
Davide Gori; Claudio Costantino; Anna Odone; Beatrice Ricci; Magda Ialonardi; Carlo Signorelli; Francesco Vitale; Maria Pia Fantini. The Impact of Mandatory Vaccination Law in Italy on MMR Coverage Rates in Two of the Largest Italian Regions (Emilia-Romagna and Sicily): An Effective Strategy to Contrast Vaccine Hesitancy. Vaccines 2020, 8, 57 .
AMA StyleDavide Gori, Claudio Costantino, Anna Odone, Beatrice Ricci, Magda Ialonardi, Carlo Signorelli, Francesco Vitale, Maria Pia Fantini. The Impact of Mandatory Vaccination Law in Italy on MMR Coverage Rates in Two of the Largest Italian Regions (Emilia-Romagna and Sicily): An Effective Strategy to Contrast Vaccine Hesitancy. Vaccines. 2020; 8 (1):57.
Chicago/Turabian StyleDavide Gori; Claudio Costantino; Anna Odone; Beatrice Ricci; Magda Ialonardi; Carlo Signorelli; Francesco Vitale; Maria Pia Fantini. 2020. "The Impact of Mandatory Vaccination Law in Italy on MMR Coverage Rates in Two of the Largest Italian Regions (Emilia-Romagna and Sicily): An Effective Strategy to Contrast Vaccine Hesitancy." Vaccines 8, no. 1: 57.
Objectives To provide a systematic review of studies that investigated the effects of Active Break (AB) school-based interventions on Physical Activity (PA) levels, classroom behavior, cognitive functions, and academic performance in primary school children. Design Systematic review and meta-analysis. Methods Searches of electronic databases and grey literature, with no time restriction and up to April 2019, resulted in 22 intervention studies meeting the inclusion criteria. Quality assessment of the studies was performed in accordance with the Cochrane Tool for Quality Assessment for RCTs and the STROBE tool for observational studies. Results Four AB related outcomes were analyzed: i) AB interventions had a significant effect in increasing PA levels in primary school children, both in terms of increased moderate to vigorous PA and step count. The meta-analysis seems to confirm this trend, showing a statistically significant result for the step count (p < 0.00001, CI95% -0.71,1.21) (random model I² = 0%). ii) Regarding classroom behavior, time spent on task (TOT) during lessons significantly increased in each of the included studies. On the other hand, the effects on iii) cognitive functions (attention components, working memory, executive functions) and iv) academic achievements (mathematics, reading) were not conclusive. Conclusions Positive effects were found for PA levels and classroom behavior, while the conflicting results for cognitive functions and academic achievements suggest that the effect could be more evident with curriculum focused active breaks and active lessons that integrate ABs with key learning aspects and cognitive engagement.
Alice Masini; Sofia Marini; Davide Gori; Erica Leoni; Andrea Rochira; Laura Dallolio. Evaluation of school-based interventions of active breaks in primary schools: A systematic review and meta-analysis. Journal of Science and Medicine in Sport 2019, 23, 377 -384.
AMA StyleAlice Masini, Sofia Marini, Davide Gori, Erica Leoni, Andrea Rochira, Laura Dallolio. Evaluation of school-based interventions of active breaks in primary schools: A systematic review and meta-analysis. Journal of Science and Medicine in Sport. 2019; 23 (4):377-384.
Chicago/Turabian StyleAlice Masini; Sofia Marini; Davide Gori; Erica Leoni; Andrea Rochira; Laura Dallolio. 2019. "Evaluation of school-based interventions of active breaks in primary schools: A systematic review and meta-analysis." Journal of Science and Medicine in Sport 23, no. 4: 377-384.
An increase of vaccine hesitancy has spread worldwide and lead to reduction in coverage rates. The trivalent Measles-Mumps-Rubella (MMR) vaccine has been one of the most targeted leading due to possible (but never proven) adverse effects. This resulted in an increase of measles cases. The aim of the study is to analyze the 24-months coverage rates for the MMR vaccine in Emilia-Romagna Region (RER) between 2007 and 2018 and to correlate any significant changes to index events. Official aggregate data on vaccination coverage at 24-month provided by the RER and the Italian Ministry of health were analyzed and discussed. From 2012 to 2015 a significant reduction in vaccination rates has been registered. In the following years an increase was recorded temporarily related to national and regional laws. The mandatory vaccination strategies seem to be in the short period effective in RER to counteract the growing population neegative attitudes towards vaccination and mitigate vaccine hesitancy.
Gori Davide; Ialonardi Magda; Odone Anna; Ricci Beatrice; Grazia Pascucci Maria; Frasca Gabriella; Venturi Sergio; Signorelli Carlo; Pia Fantini Maria; Davide Gori; Magda Ialonardi; Anna Odone; Beatrice Ricci; Maria Grazia Pascucci; Gabriella Frasca; Sergio Venturi; Carlo Signorelli; Maria Pia Fantini. Vaccine Hesitancy and Mandatory Immunizations in Emilia-Romagna Region: the case of MMR vaccine. 2019, 90, 394 -397.
AMA StyleGori Davide, Ialonardi Magda, Odone Anna, Ricci Beatrice, Grazia Pascucci Maria, Frasca Gabriella, Venturi Sergio, Signorelli Carlo, Pia Fantini Maria, Davide Gori, Magda Ialonardi, Anna Odone, Beatrice Ricci, Maria Grazia Pascucci, Gabriella Frasca, Sergio Venturi, Carlo Signorelli, Maria Pia Fantini. Vaccine Hesitancy and Mandatory Immunizations in Emilia-Romagna Region: the case of MMR vaccine. . 2019; 90 (3):394-397.
Chicago/Turabian StyleGori Davide; Ialonardi Magda; Odone Anna; Ricci Beatrice; Grazia Pascucci Maria; Frasca Gabriella; Venturi Sergio; Signorelli Carlo; Pia Fantini Maria; Davide Gori; Magda Ialonardi; Anna Odone; Beatrice Ricci; Maria Grazia Pascucci; Gabriella Frasca; Sergio Venturi; Carlo Signorelli; Maria Pia Fantini. 2019. "Vaccine Hesitancy and Mandatory Immunizations in Emilia-Romagna Region: the case of MMR vaccine." 90, no. 3: 394-397.