Microwave irradiation has been used to accelerate the synthesis of the Biginelli compounds, in one-pot reaction between β-keto esters, aryl aldehydes, and urea. These solvent-free reactions show that it is possible to prepare these compounds in a short time reaction and with good yield and easily isolable.
The catalytic application of Cu(INA)2-MOF in click and Biginelli reactions was investigated and a comparative study with the [Cu(INA)2(H2O)4] complex was performed.