Prof. MIroslav Pohanka
Faculty of Military Health Sciences; University of Defense, Brno; Trebesska 1575, 50001 Hradec Kralove, Czech Republic
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Academic Career Length
22Years (2005-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
MIroslav PohankaPiezoelectric biosensors are a group of analytical devices working on a principle of affinity interaction recording. A piezoelectric platform or piezoelectric crystal is a sensor part working on the principle of oscillations change due to a mass bound on the piezoelectric crystal surface. In this review, biosensors having their surface modified with an antibody or antigen, with a molecularly imprinted polymer, with genetic information like single stranded DNA, and biosensors with bound receptors of organic of biochemical origin, are presented and discussed. The mentioned recognition parts are frequently combined with use of nanoparticles and applications in this way are also introduced. An overview of the current literature is given and the methods presented are commented upon.
1 September 2011 in Biomedical Papers
Journal Article
MIroslav PohankaBackground: Cholinesterases are a group of serine hydrolases that split the neurotransmitter acetylcholine (ACh) and terminate its action. Of the two types, butyrylcholinesterase and acetylcholinesterase (AChE), AChE plays the key role in endi...
31 July 2008 in Journal of Applied Biomedicine
Journal Article
MIroslav PohankaPSPetr Skládal
Petr Skládal
The first scientifically proposed as well as successfully commercialized biosensors were those based on electrochemical sensors for multiple analytes. Electrochemical biosensors have been studied for a long time. Currently, transducers based o...
Journal Article
MIroslav PohankaAcetylcholinesterase (AChE) inhibitors are widely used for the symptomatic treatment of Alzheimer’s disease and other dementias. More recent use is for myasthenia gravis. Many of these inhibitors interact with the second known cholinesterase, butyrylcholinesterase (BChE). Further, evidence shows that acetylcholine plays a role in suppression of cytokine release through a “cholinergic anti-inflammatory pathway” which raises questions about the role of these inhibitors in the immune system. This review covers research and discussion of the role of the inhibitors in modulating the immune response using as examples the commonly available drugs, donepezil, galantamine, huperzine, neostigmine and pyridostigmine. Major attention is given to the cholinergic anti-inflammatory pathway, a well-described link between the central nervous system and terminal effector cells in the immune system.
1 January 2020 in BioMed Research International
Journal Article
MIroslav PohankaTwo enantiomers of lactic acid exist. While L‐lactic acid is a common compound of human metabolism, D‐lactic acid is produced by some strains of microorganism or by some less relevant metabolic pathways. While L‐lactic acid is an endogenous compound, D‐lactic acid is a harmful enantiomer. Exposure to D‐lactic acid can happen by various ways including contaminated food and beverages and by microbiota during some pathological states like short bowel syndrome. The exposure to D‐lactic acid cannot be diagnosed because the common analytical methods are not suitable for distinguishing between the two enantiomers. In this review, pathways for D‐lactic acid, pathological processes, and diagnostical and analytical methods are introduced followed by figures and tables. The current literature is summarized and discussed.
1 January 2017 in International Journal of Electrochemical Science
Journal Article
MIroslav PohankaAbout Me
Miroslav Pohanka studied biochemistry at Masaryk University Brno (Czech Republic) and graduated in 2003. At Masaryk University, he earned a Doctor of Natural Science (RNDr) in biochemistry in 2006 and a PhD in biochemistry in 2008. After that, he became an associate professor in toxicology at the University
of Defense, Czech Republic (2012), a doctor of sciences in analytical chemistry at the Academy of Sciences, Czech Republic (2014), and a professor of analytical chemistry at the University of Pardubice (2016). Currently, he is a professor in the Department of Molecular Pathology and Biology (and became head of the department in 2024), Military Faculty of Medicine, University of Defence, Hradec Kralove, Czech Republic, where he devotes his work to the construction of biosensors and bioanalytical methods. He is responsible for the education of students in this field. Researcher ID: D-7607-2012, ORCID: 0000-0001-8804-8356.