Saïd El Kazzouli

Prof. Saïd El Kazzouli

Euromed Research Center, Euromed Institute of Technology, Euromed University of Fes, Route de Meknes, 30000 Fes, Morocco
orcid

Research Focus & Metrics

Academic Career Length

21Years (2006-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 June 2014 in European Journal of Organic Chemistry
Verified
Journal Article
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koubachi jamalkoubachi jamal
koubachi jamal
SKSaïd El Kazzouli
Saïd El Kazzouli
MBMosto Bousmina
Mosto Bousmina
GGGerald Guillaumet
Gerald Guillaumet

19 January 2015 in RSC Advances
Verified
Journal Article
Closed access
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SKSaïd El Kazzouli
Saïd El Kazzouli
koubachi jamalkoubachi jamal
koubachi jamal
NBNabil El Brahmi
Nabil El Brahmi
GGGerald Guillaumet
Gerald Guillaumet
Direct arylation is a useful method for the preparation of (hetero)aryl–aryl systems by C–H bond cleavage. This procedure has several advantages such as the reduction of cost, time and waste. This report aims at reviewing the advances made in C–H arylation of 5,6, 6,6 and 5,5 fused-heterocyclic systems including: indole, azaindole, imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine, imidazo[1,2-a]pyrazine, imidazo[1,2-b]pyridazine, pyrazolo[1,5-a]pyrimidine, imidazo[1,2-b][1,2,4,5]tetrazine, indolizine, pyrrolo[1,2-a]pyrazine, indazole, benzothiadiazole, benzotriazole, benzoxazole, benzofuran, benzothiophene, benzimidazole, benzothiazole, thieno[3,4-b]pyrazine, indolizine-2-carboxylate, thieno[3,4-b]pyrazine, quinoline and derivatives, chromanone, coumarin, quinoxaline, thieno[2,3-b]thiophene, thieno[3,4-b]thiophene, imidazo[2,1-b]thiazole, imidazo[1,2-b]pyrazole, thiazolo[3,2-b][1,2,4]triazoles and pyrrolo[3,2-b]pyrrole.

1 October 2016 in European Journal of Medicinal Chemistry
Verified
Journal Article
Closed access
SMSerge Mignani
Serge Mignani
NBNabil El Brahmi
Nabil El Brahmi
SKSaïd El Kazzouli
Saïd El Kazzouli
LELaure Eloy
Laure Eloy
DCDelphine Courilleau
Delphine Courilleau
JMJean-Pierre Majoral
Jean-Pierre Majoral

1 May 2019 in Drug Discovery Today
Verified
Journal Article
Closed access
SMSerge Mignani
Serge Mignani
João RodriguesJoão Rodrigues
João Rodrigues
René RoyRené Roy
René Roy
XSXiangyang Shi
Xiangyang Shi
VCValentín Ceña
Valentín Ceña
JMJean-Pierre Majoral
Jean-Pierre Majoral

17 August 2022 in Molecules
Verified
Journal Article
Open access
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OBOtmane BOURZIKAT
Otmane BOURZIKAT
AAABDELMOULA EL ABBOUCHI
ABDELMOULA EL ABBOUCHI
HGHamza Ghammaz
Hamza Ghammaz
NBNabil EL BRAHMI
Nabil EL BRAHMI
EFElmostafa El Fahime
Elmostafa El Fahime
SKSaïd El Kazzouli
Saïd El Kazzouli
In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities. The structures of these derivatives were elucidated by 1H NMR, 13C NMR, infrared and high-resolution mass spectrometry for further validation of the target compound structures. The anticancer activities of the new molecules were evaluated against five human cancer cell lines, including A-549, Hs-683, MCF-7, SK-MEL-28 and B16-F10 cell lines using 5-fluorouracil and etoposide as the reference drugs. Among the tested compounds, 4e and 4f exhibited excellent activities in the same range of the positive controls, 5-fluorouracil and etoposide, against MCF-7 and SK-MEL-28 cancer cell lines, with IC50 values ranging from 1 to 10 μM. The molecular docking studies of 4e and 4f showed a strong binding with some kinases, which are linked to MCF-7 and SK-MEL-28 cancer cell lines.

13 November 2017 in The Journal of Organic Chemistry
Verified
Journal Article
Closed access
SFSoukaina Faarasse
Soukaina Faarasse
SKSaïd El Kazzouli
Saïd El Kazzouli
MNMohammed Naas
Mohammed Naas
JJJabrane Jouha
Jabrane Jouha
FSFranck Suzenet
Franck Suzenet
GGGerald Guillaumet
Gerald Guillaumet