karim benabdellah

Dr. karim benabdellah

Genomic Medicine Department, GENYO, Centre for Genomics and Oncological Research
orcid

Research Focus & Metrics

Academic Career Length

29Years (1998-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 November 2011 in New Phytologist
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Journal Article
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ETE. Tisserant
E. Tisserant
AKA. Kohler
A. Kohler
PDP. Dozolme‐Seddas
P. Dozolme‐Seddas
Raffaella BalestriniRaffaella Balestrini
Raffaella Balestrini
karim benabdellahkarim benabdellah
karim benabdellah
FMFrancis Martin
Francis Martin

30 December 2020 in Cancers
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Journal Article
Open access
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HAHoussam Aheget
Houssam Aheget
LMLoubna Mazini
Loubna Mazini
Francisco MartinFrancisco Martin
Francisco Martin
BBBoutaïna BELQAT
Boutaïna BELQAT
Juan Antonio MarchalJuan Antonio Marchal
Juan Antonio Marchal
karim benabdellahkarim benabdellah
karim benabdellah
Exosomes are lipid bilayer particles released from cells into their surrounding environment. These vesicles are mediators of near and long-distance intercellular communication and affect various aspects of cell biology. In addition to their biological function, they play an increasingly important role both in diagnosis and as therapeutic agents. In this paper, we review recent literature related to the molecular composition of exosomes, paying special attention to their role in pathogenesis, along with their application as biomarkers and as therapeutic tools. In this context, we analyze the potential use of exosomes in biomedicine, as well as the limitations that preclude their wider application.

17 July 2025 in Molecular Therapy Nucleic Acids
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Journal Article
Open access
NKNechama Kalter
Nechama Kalter
CFCarla Fuster-García
Carla Fuster-García
ASAlfredo Silva
Alfredo Silva
VRVíctor Ronco-Díaz
Víctor Ronco-Díaz
SRStefano Roncelli
Stefano Roncelli
Ayal HendelAyal Hendel
Ayal Hendel
Targeted nucleases, primarily CRISPR-Cas-based systems, have revolutionized genome editing by enabling precise modification of target genes or transcripts. Many pre-clinical and clinical studies leverage this technology to develop treatments for human diseases; however, substantial off-target genotoxicity concerns delay its clinical translation. Despite the development of a wide array of tools, assays, and technologies aimed at identifying and quantifying off-target effects, the absence of standardized guidelines leads to inconsistent practices across studies. This review highlights the key challenges and potential solutions in ensuring the safety of gene editing studies for therapeutic applications, focusing on gRNA design, off-target sites prediction, and off-target activity measurement.

27 August 2009 in Mycorrhiza
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Journal Article
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Manuel Gonzalez-GuerreroManuel Gonzalez-Guerrero
Manuel Gonzalez-Guerrero
karim benabdellahkarim benabdellah
karim benabdellah
AVAscensión Valderas
Ascensión Valderas
CAConcepción Azcón Aguilar
Concepción Azcón Aguilar
NFNuria Ferrol
Nuria Ferrol

21 April 2009 in Phytochemistry Reviews
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Nuria Ferrol GonzálezNuria Ferrol González
Nuria Ferrol González
Manuel Gonzalez-GuerreroManuel Gonzalez-Guerrero
Manuel Gonzalez-Guerrero
AVAscensión Valderas
Ascensión Valderas
karim benabdellahkarim benabdellah
karim benabdellah
CAConcepción Azcón Aguilar
Concepción Azcón Aguilar

Verified
Journal Article
Open access
PDF file
HAHoussam Aheget
Houssam Aheget
MTMaría Tristán-Manzano
María Tristán-Manzano
LMLoubna Mazini
Loubna Mazini
MCMarina Cortijo-Gutierrez
Marina Cortijo-Gutierrez
Pablo Galindo-MorenoPablo Galindo-Moreno
Pablo Galindo-Moreno
karim benabdellahkarim benabdellah
karim benabdellah
Summary: Exosomes are extracellular vesicles released by the vast majority of cell types both in vivo and ex vivo, upon the fusion of multivesicular bodies (MVBs) with the cellular plasma membrane. Two main functions have been attributed to exosomes: their capacity to transport proteins, lipids and nucleic acids between cells and organs, as well as their potential to act as natural intercellular communicators in normal biological processes and in pathologies. From a clinical perspective, the majority of applications use exosomes as biomarkers of disease. A new approach uses exosomes as biologically active carriers to provide a platform for the enhanced delivery of cargo in vivo. One of the major limitations in developing exosome-based therapies is the difficulty of producing sufficient amounts of safe and efficient exosomes. The identification of potential proteins involved in exosome biogenesis is expected to directly cause a deliberate increase in exosome production. In this review, we summarize the current state of knowledge regarding exosomes, with particular emphasis on their structural features, biosynthesis pathways, production techniques and potential clinical applications.