The mission of my research activities pertains to the investigation of the mechanical functionality of biological tissues and structures and the optimization of surgical procedures, biomedical devices, and sport equipment. Activities are defined considering the actual clinical and surgical demand and the partnership with industries operating in the biomedical field and the sport system. A unique research approach is followed, where in silico mathematical modelling, in vitro biomechanical experimentations on human and animal tissues and structures, and in vivo animal models are synergistically integrated to rationally design and validate novel procedures and devices. In detail, experimentations are developed to define and identify computational models of the anatomical districts, which subsequently are exploited to evaluate the functional response considering a broad range of situations.