Cancer is a non-contagious disease that is the leading cause of death globally. The most common types of cancer with high mortality are lung and colon cancer. One of the efforts to reduce cases of death is early diagnosis followed by medical therapy. Tissue sampling and clinical pathological examination are the gold standard in cancer diagnosis. However, in some cases, pathological examination of tissue to the cell level requires high accuracy, depending on the contrast of the pathological image, and the experience of the clinician. Therefore, we need an image processing approach combined with artificial intelligence for automatic classification. In this study, a method is proposed for automatic classification of lung and colon cancer based on a deep learning approach. The object of the image that is classified is the histopathological image of normal tissue, benign cancer, and malignant cancer. Convolutional neural network (CNN) with VGG16 architecture and Contrast Limited Adaptive Histogram Equalization (CLAHE) were employed for demonstration of classification on 25000 histopathological images. The simulation results show that the proposed method is able to classify with a maximum accuracy of 98.96%. The system performance using CLAHE shows a higher detection accuracy than without using CLAHE and is consistent for all epoch scenarios. The comparative study shows that the proposed method outperforms some previous studies. With this proposed method, it is hoped that it can help clinicians in diagnosing cancer automatically, with low cost, high accuracy, and fast processing on large datasets.
27 March 2023 in Biomedical Signal Processing and Control
The EEG is one of the main medical instruments used by clinicians in the analysis and diagnosis of epilepsy through visual observations or computers. Visual inspection is difficult, time-consuming, and cannot be conducted in real time. Therefore, we propose a digital system for the classification of epileptic EEG in real time on a Field Programmable Gate Array (FPGA). The implemented digital system comprised a communication interface, feature extraction, and classifier model functions. The Hjorth descriptor method was used for feature extraction of activity, mobility, and complexity, with KNN was utilized as a predictor in the classification stage. The proposed system, run on a The Zynq-7000 FPGA device, can generate up to 90.74% accuracy in normal, inter-ictal, and ictal EEG classifications. FPGA devices provided classification results within 0.015 s. The total memory LUT resource used was less than 10%. This system is expected to tackle problems in visual inspection and computer processing to help detect epileptic EEG using low-cost resources while retaining high performance and real-time implementation.
22 March 2022 in International Journal of Online and Biomedical Engineering (iJOE)
Electrocardiogram (ECG) analysis is one of the gold standards in diagnosing heart abnormalities. Commonly, clinicians analyze the ECG signal visually by observing the shape, rhythm, and voltage of the signal. Some of them are supported by the application of automatic diagnosis of the ECG device itself. Currently, digital signal processing combined with traditional or advanced machine learning plays an important role in supporting medical diagnosis including ECG diagnosis. However, it is often constrained by the lack of raw data support from most commercial ECG devices. Classification method by processing ECG image can be one way to tackle this problem. Therefore, in this preliminary study, an image-based ECG classification method using a deep learning approach is proposed. The ECG signals analyzed in this study include normal sinus rhythm (NSR), premature ventricular contraction (PVC), and Bigeminy. Convolutional neural network (CNN) with VGG16 architecture has been employed for feature extraction and classification. The simulation results show up to 95% accuracy in detecting ECG abnormalities. The results of this study can be an alternative in detecting ECG abnormalities and can be considered as a supporting diagnosis by the clinician.
Epilepsy is the most common form of neurological disease. Patients with epilepsy may experience seizures of a certain duration with or without provocation. Epilepsy analysis can be done with an electroencephalogram (EEG) examination. Observation of qualitative EEG signals generates high cost and often confuses due to the nature of the non-linear EEG signal and noise. In this study, we proposed an EEG signal processing system for EEG seizure detection. The signal dynamics approach to normal and seizure signals' characterization became the main focus of this study. Spectral Entropy (SpecEn) and fractal analysis are used to estimate the EEG signal dynamics and used as feature sets. The proposed method is validated using a public EEG dataset, which included preictal, ictal, and interictal stages using the Naïve Bayes classifier. The test results showed that the proposed method is able to generate an ictal detection accuracy of up to 100%. It is hoped that the proposed method can be considered in the detection of seizure signals on the long-term EEG recording. Thus it can simplify the diagnosis of epilepsy.
Sensor-based human activity recognition (HAR) is a method for observing a person’s activity in an environment. With this method, it is possible to monitor remotely. HAR can analyze a person’s gait, whether normal or abnormal. Some of its applications may use several sensors mounted on the body, but this method tends to be complex and inconvenient. One alternative to wearable sensors is using video. One of the most commonly used HAR platforms is PoseNET. PoseNET is a sophisticated platform that can detect the skeleton and joints of the body, which are then known as joints. However, a method is still needed to process the raw data from PoseNET to detect subject activity. Therefore, this research proposes a way to detect abnormalities in gait using empirical mode decomposition and the Hilbert spectrum and transforming keys-joints, and skeletons from vision-based pose detection into the angular displacement of walking gait patterns (signals). Joint change information is extracted using the Hilbert Huang Transform to study how the subject behaves in the turning position. Furthermore, it is determined whether the transition goes from normal to abnormal subjects by calculating the energy in the time-frequency domain signal. The test results show that during the transition period, the energy of the gait signal tends to be higher than during the walking period.