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Dr. Giulia Genoni
Neonatal and Pediatric Intensive Care Unit, Azienda Ospedaliero Universitaria Maggiore della Carità, Novara, 28100, Italy

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0 Neonatology
0 Nutrition
0 Simulation
0 Pediatric Cardiology
0 Prematurity

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Journal article
Published: 23 July 2021 in JMIR Pediatrics and Parenting
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Background Since the beginning of the COVID-19 pandemic, a great number of papers have been published in the pediatric field. Objective We aimed to assess research around the globe on COVID-19 in the pediatric field by bibliometric analysis, identifying publication trends and topic dissemination and showing the relevance of publishing authors, institutions, and countries. Methods The Scopus database was comprehensively searched for all indexed documents published between January 1, 2020, and June 11, 2020, dealing with COVID-19 in the pediatric population (0-18 years). A machine learning bibliometric methodology was applied to evaluate the total number of papers and citations, journal and publication types, the top productive institutions and countries and their scientific collaboration, and core keywords. Results A total of 2301 papers were retrieved, with an average of 4.8 citations per article. Of this, 1078 (46.9%) were research articles, 436 (18.9%) were reviews, 363 (15.8%) were letters, 186 (8.1%) were editorials, 7 (0.3%) were conference papers, and 231 (10%) were categorized as others. The studies were published in 969 different journals, headed by The Lancet. The retrieved papers were published by a total of 12,657 authors from 114 countries. The most productive countries were the United States, China, and Italy. The four main clusters of keywords were pathogenesis and clinical characteristics (keyword occurrences: n=2240), public health issues (n=352), mental health (n=82), and therapeutic aspects (n=70). Conclusions In the pediatric field, a large number of articles were published within a limited period on COVID-19, testifying to the rush to spread new findings on the topic in a timely manner. The leading authors, countries, and institutions evidently belonged to the most impacted geographical areas. A focus on the pediatric population was often included in general articles, and pediatric research about COVID-19 mainly focused on the clinical features, public health issues, and psychological impact of the disease.

ACS Style

Alice Monzani; Francesco Tagliaferri; Simonetta Bellone; Giulia Genoni; Ivana Rabbone. A Global Overview of COVID-19 Research in the Pediatric Field: Bibliometric Review. JMIR Pediatrics and Parenting 2021, 4, e24791 .

AMA Style

Alice Monzani, Francesco Tagliaferri, Simonetta Bellone, Giulia Genoni, Ivana Rabbone. A Global Overview of COVID-19 Research in the Pediatric Field: Bibliometric Review. JMIR Pediatrics and Parenting. 2021; 4 (3):e24791.

Chicago/Turabian Style

Alice Monzani; Francesco Tagliaferri; Simonetta Bellone; Giulia Genoni; Ivana Rabbone. 2021. "A Global Overview of COVID-19 Research in the Pediatric Field: Bibliometric Review." JMIR Pediatrics and Parenting 4, no. 3: e24791.

Journal article
Published: 15 April 2021 in Nutrients
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Background: The aim of this study was to determine the effects of a 12-month healthy lifestyle intervention based on diet plus physical activity on cardiovascular structure and function in children and adolescents with obesity; Methods: In this longitudinal study we assessed changes in anthropometric, biochemical and cardiovascular variables in 55 subjects with obesity (6–16 years) before and after a 12-month behavioral program based on Mediterranean diet plus exercise regimen. Subjects were divided in two groups based on negative change in BMI z-score ≥10% from baseline: weight losers (WL) and non-weight losers (NWL); Results: After 12 months, WL showed a significant improvement of metabolic parameters. Treatment was effective in increasing the mitral peak early diastolic velocity E and the E/A ratio. In subjects with a reduction of the number of NCEP-ATPIII metabolic syndrome criteria, lifestyle intervention reduced left ventricular area and volume. Intervention reduced carotid intima-media thickness in subjects showing a decrease of the systemic blood pressure; Conclusions: In children with obesity, cardiovascular impairment could be partially reversed by a healthy lifestyle intervention. To adopt prompt behavioral programs in childhood obesity is crucial both for prevention and treatment of precocious complications and could have an exponential impact on long-term morbidity and mortality.

ACS Style

Giulia Genoni; Veronica Menegon; Alice Monzani; Francesca Archero; Francesco Tagliaferri; Valentina Mancioppi; Caterina Peri; Simonetta Bellone; Flavia Prodam. Healthy Lifestyle Intervention and Weight Loss Improve Cardiovascular Dysfunction in Children with Obesity. Nutrients 2021, 13, 1301 .

AMA Style

Giulia Genoni, Veronica Menegon, Alice Monzani, Francesca Archero, Francesco Tagliaferri, Valentina Mancioppi, Caterina Peri, Simonetta Bellone, Flavia Prodam. Healthy Lifestyle Intervention and Weight Loss Improve Cardiovascular Dysfunction in Children with Obesity. Nutrients. 2021; 13 (4):1301.

Chicago/Turabian Style

Giulia Genoni; Veronica Menegon; Alice Monzani; Francesca Archero; Francesco Tagliaferri; Valentina Mancioppi; Caterina Peri; Simonetta Bellone; Flavia Prodam. 2021. "Healthy Lifestyle Intervention and Weight Loss Improve Cardiovascular Dysfunction in Children with Obesity." Nutrients 13, no. 4: 1301.

Research article
Published: 08 February 2021 in BioMed Research International
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Background and Objectives. An association between developmental dyslexia and autoimmune disorders has been postulated. We aimed to evaluate the prevalence of thyroid autoimmunity in pediatric subjects with developmental dyslexia. Methods. We enrolled pediatric subjects with developmental dyslexia and, as a control group, healthy age- and sex-matched subjects without developmental dyslexia. Thyroid function was evaluated in subjects with developmental dyslexia measuring serum concentrations of thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). Thyroid autoimmunity was evaluated in all subjects measuring antithyroid peroxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibodies. In subjects with developmental dyslexia, thyroid ultrasonography (US) was also performed. Results. We enrolled 51 subjects with developmental dyslexia ( M : F = 39 : 12 , mean age 12.4 ± 9 years) and 34 controls ( M : F = 24 : 10 , mean age 10.8 ± 4 years). TPO-Ab positivity was significantly higher in subjects with developmental dyslexia compared to controls (60.8% vs. 2.9%, p < 0.001 ), while no significant difference was found in TG-Ab positivity (16% vs. 5.8%). Thyroid US performed in 49 subjects with developmental dyslexia revealed a thyroiditis pattern in 60%. Conclusions. We found an extremely high prevalence of thyroid autoimmunity in children with developmental dyslexia. Further studies are needed to confirm our observations, but our findings may change the approach to this disorder and eventually lead to a systematic determination of thyroid autoimmunity in children with developmental dyslexia.

ACS Style

Roberta Degrandi; Flavia Prodam; Giulia Genoni; Giorgio Bellomo; Gianni Bona; Mara Giordano; Simonetta Bellone; Alice Monzani. The Prevalence of Thyroid Autoimmunity in Children with Developmental Dyslexia. BioMed Research International 2021, 2021, 1 -5.

AMA Style

Roberta Degrandi, Flavia Prodam, Giulia Genoni, Giorgio Bellomo, Gianni Bona, Mara Giordano, Simonetta Bellone, Alice Monzani. The Prevalence of Thyroid Autoimmunity in Children with Developmental Dyslexia. BioMed Research International. 2021; 2021 ():1-5.

Chicago/Turabian Style

Roberta Degrandi; Flavia Prodam; Giulia Genoni; Giorgio Bellomo; Gianni Bona; Mara Giordano; Simonetta Bellone; Alice Monzani. 2021. "The Prevalence of Thyroid Autoimmunity in Children with Developmental Dyslexia." BioMed Research International 2021, no. : 1-5.

Review
Published: 08 September 2020 in American Journal of Perinatology
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Objective We aimed at reviewing the currently available guidelines and scientific recommendations regarding the neonatal in-hospital management and feeding in the light of the coronavirus disease 2019 (COVID-19) pandemic. Study Design We systematically searched the guideline databases, Medline, Embase, and nationale/international neonatal societies websites as of June 19, 2020, for guidelines on neonatal management and feeding during the COVID-19 pandemic, at the same time assessing the methodological quality using the Appraisal of Guidelines for Research and Evaluation II tool. Results Eleven guidelines were included. The Chinese and American recommendations suggest separation of the mother and her neonate, whereas in French, Italian, UK, Canadian, and World Health Organization consensus documents the rooming-in is suggested, with Centers for Disease Control and Prevention guidelines suggesting to decide on a case-by-case basis. All the guidelines recommend breastfeeding or feeding with expressed maternal milk; the only exception is the Chinese recommendations, these last suggesting to avoid breastfeeding. Conclusion This review may provide a useful tool for clinicians and organizers, highlighting differences and similarities of the existing guidelines on the management and feeding strategies in the light of the COVID-19 pandemic. Key Points

ACS Style

Giulia Genoni; Alessandra Conio; Marco Binotti; Paolo Manzoni; Matteo Castagno; Ivana Rabbone; Alice Monzani. Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations. American Journal of Perinatology 2020, 37, S46 -S53.

AMA Style

Giulia Genoni, Alessandra Conio, Marco Binotti, Paolo Manzoni, Matteo Castagno, Ivana Rabbone, Alice Monzani. Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations. American Journal of Perinatology. 2020; 37 (S 02):S46-S53.

Chicago/Turabian Style

Giulia Genoni; Alessandra Conio; Marco Binotti; Paolo Manzoni; Matteo Castagno; Ivana Rabbone; Alice Monzani. 2020. "Management and Nutrition of Neonates during the COVID-19 Pandemic: A Review of the Existing Guidelines and Recommendations." American Journal of Perinatology 37, no. S 02: S46-S53.

Instructive case
Published: 10 August 2020 in Journal of Paediatrics and Child Health
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ACS Style

Alice Monzani; Giulia Genoni; Marco Binotti; Francesco Tagliaferri; Ivana Rabbone; Pier Luigi Ingrassia. Management of a suspected case of 2019 novel coronavirus infection in a 4‐year old child: A simulation scenario. Journal of Paediatrics and Child Health 2020, 57, 743 -746.

AMA Style

Alice Monzani, Giulia Genoni, Marco Binotti, Francesco Tagliaferri, Ivana Rabbone, Pier Luigi Ingrassia. Management of a suspected case of 2019 novel coronavirus infection in a 4‐year old child: A simulation scenario. Journal of Paediatrics and Child Health. 2020; 57 (5):743-746.

Chicago/Turabian Style

Alice Monzani; Giulia Genoni; Marco Binotti; Francesco Tagliaferri; Ivana Rabbone; Pier Luigi Ingrassia. 2020. "Management of a suspected case of 2019 novel coronavirus infection in a 4‐year old child: A simulation scenario." Journal of Paediatrics and Child Health 57, no. 5: 743-746.

Journal article
Published: 28 February 2020 in Nutrients
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Background: Kidney function in preterm newborns may be impaired by many factors. Methods: 71 newborns with gestational age (GA) < 32 weeks were enrolled. Serum creatinine (sCr), cystatin C (CysC), beta-trace protein (BTP) and urea were measured at T0 (3rd day of life) and T36 (GA 36 weeks), and estimated glomerular filtration rate (eGFR) was calculated according to different formulas at T36. Pre-natal and post-natal kidney injury risk scores were calculated. Results: Newborns with GA ≤ 28 weeks had higher sCr at T0, and lower sCr, BTP and higher urea levels at T36 (p = 0.007, p = 0.005 and p = 0.029, respectively). eGFR values were not different according to GA when calculated by the formulas using only CysC, but were higher in subjects with GA ≤ 28 weeks according to the other formulas. The post-natal score was positively correlated with eGFR according to sCr-based formulas, but the correlations did not persist when adjusted for urea levels and GA. Conclusions: CysC-based eGFR values are not influenced by GA. Post-natal score shows a direct correlation with eGFR according to sCr-based formulas, not persisting after adjustment for GA and urea levels, implying the importance of the nutritional status, since more premature subjects receive a more aggressive nutritional regimen, testified by higher urea levels.

ACS Style

Alice Monzani; Ilaria Crespi; Giulia Genoni; Alberto Edefonti; Giovanni Montini; Giorgio Bellomo; Federica Ferrero; Simonetta Bellone; Flavia Prodam. Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition. Nutrients 2020, 12, 651 .

AMA Style

Alice Monzani, Ilaria Crespi, Giulia Genoni, Alberto Edefonti, Giovanni Montini, Giorgio Bellomo, Federica Ferrero, Simonetta Bellone, Flavia Prodam. Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition. Nutrients. 2020; 12 (3):651.

Chicago/Turabian Style

Alice Monzani; Ilaria Crespi; Giulia Genoni; Alberto Edefonti; Giovanni Montini; Giorgio Bellomo; Federica Ferrero; Simonetta Bellone; Flavia Prodam. 2020. "Kidney-Detrimental Factors and Estimated Glomerular Filtration Rate in Preterm Newborns: The Role of Nutrition." Nutrients 12, no. 3: 651.

Journal article
Published: 22 May 2019 in BMC Medical Education
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A prompt start to an appropriate neonatal and paediatric resuscitation is critical to reduce mortality and morbidity. However, residents are rarely exposed to real emergency situations. Simulation-based medical training (SBMT) offers the opportunity to improve medical and non-technical skills in a controlled setting. This survey describes the availability and current use of SBMT by paediatric residents in Italy with the purpose of understanding residents' expectations regarding neonatal and paediatric emergency training, and identifying gaps and potential areas for future implementation. A survey was developed and distributed to Italian residents. SBMT was defined as any kind of training with a mannequin in a contextualised clinically realistic scenario. The response rate was 14.4%, covering the 71% of Italian paediatric residency programmes. Among them, 88% stated that Out of the 274 residents, 88% stated that they received less than 5 h of SBMT during the past training year, with 66% not participating in any kind of simulation activity. In 62% of the programmes no simulation training facility was available to residents. Among those who received SBMT, 46% used it for procedures and skills, 30% for clinical scenarios, but only 24% of them reported a regular use for debriefing. Of the overall respondents, 93% were interested in receiving SBMT to improve decision-making abilities in complex medical situations, to improve technical/procedural skills, and to improve overall competency in neonatal and paediatric emergencies, including non-technical skills. The main barriers to the implementation of SBMT programmes in Italian paediatric residencies were: the lack of experts (57%), the lack of support from the school director (56%), the lack of organisation in planning simulation centre courses (42%) and the lack of teaching materials (42%). This survey shows the scarce use of SBMT during paediatric training programmes in Italy and points out the main limitations to its diffusion. This is a call to action to develop organised SBMT during paediatric residency programs, to train qualified personnel, and to improve the quality of education and care in this field.

ACS Style

Marco Binotti; Giulia Genoni; Stefano Rizzollo; Marco De Luca; Luca Carenzo; Alice Monzani; Pier Luigi Ingrassia. Simulation-based medical training for paediatric residents in Italy: a nationwide survey. BMC Medical Education 2019, 19, 161 .

AMA Style

Marco Binotti, Giulia Genoni, Stefano Rizzollo, Marco De Luca, Luca Carenzo, Alice Monzani, Pier Luigi Ingrassia. Simulation-based medical training for paediatric residents in Italy: a nationwide survey. BMC Medical Education. 2019; 19 (1):161.

Chicago/Turabian Style

Marco Binotti; Giulia Genoni; Stefano Rizzollo; Marco De Luca; Luca Carenzo; Alice Monzani; Pier Luigi Ingrassia. 2019. "Simulation-based medical training for paediatric residents in Italy: a nationwide survey." BMC Medical Education 19, no. 1: 161.

Journal article
Published: 05 April 2019 in Minerva Pediatrica
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Gianluca Cosi; Alice Monzani; Giulia Genoni; Simona De Franco; Silvia Parlamento; Gianni Bona; Federica Ferrero. Weaning in Neurally Adjusted Ventilatory Assist (NAVA): a prospective interventional study in neonates. Minerva Pediatrica 2019, 1 .

AMA Style

Gianluca Cosi, Alice Monzani, Giulia Genoni, Simona De Franco, Silvia Parlamento, Gianni Bona, Federica Ferrero. Weaning in Neurally Adjusted Ventilatory Assist (NAVA): a prospective interventional study in neonates. Minerva Pediatrica. 2019; ():1.

Chicago/Turabian Style

Gianluca Cosi; Alice Monzani; Giulia Genoni; Simona De Franco; Silvia Parlamento; Gianni Bona; Federica Ferrero. 2019. "Weaning in Neurally Adjusted Ventilatory Assist (NAVA): a prospective interventional study in neonates." Minerva Pediatrica , no. : 1.

Case report
Published: 09 January 2019 in BMC Medical Genomics
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Mutations of SHOX represent the most frequent monogenic cause of short stature and related syndromes. The genetic alterations include point mutations and deletions/duplications spanning both SHOX and its regulatory regions, although microrearrangements are confined to either the downstream or upstream enhancers in many patients. Mutations in the heterozygous state have been identified in up to 60–80% of Leri-Weill Dyschondrosteosis (LWD; MIM #127300) and approximately 4–5% of Idiopathic Short Stature (ISS; MIM#300582) patients. Homozygous or compound heterozygous mutations as well as biallelic deletions of SHOX and/or the enhancer regions result in a more severe phenotype, which is known as Langer Mesomelic Dysplasia (LMD; MIM #249700). A 17 year old girl, presented with severe short stature, growth hormone deficiency (GHD), precocious puberty, dorsal scoliosis, dysmorphisms and urogenital malformations. She was born with agenesis of the right tibia and fibula, as well as with a supernumerary digit on the left foot. Array comparative genomic hybridization (aCGH) analysis detected the presence of two distinct duplications on Xp22.1 flanking the SHOX coding sequence and involving its regulatory regions. An additional duplication of 1.6–2.5 Mb on 15q25.2 that included 13 genes was also identified. The girl was adopted and the parent’s DNA was not available to establish the origin of the chromosome imbalances. The complex phenotype observed in our patient is probably the result of the co-occurrence of rearrangements on chromosomes Xp22.1 and 15q25.2. The duplicated region on 15q25.2 region is likely to contain dosage-sensitive genes responsible for some of the clinical features observed in this patient, whereas the extreme short stature and the skeletal anomalies are likely attributable to the comorbidity of GHD and copy number variants in the SHOX region. The online version of this article (10.1186/s12920-018-0445-8) contains supplementary material, which is available to authorized users.

ACS Style

Alice Monzani; Deepak Babu; Simona Mellone; Giulia Genoni; Antonella Fanelli; Flavia Prodam; Simonetta Bellone; Mara Giordano. Co-occurrence of genomic imbalances on Xp22.1 in the SHOX region and 15q25.2 in a girl with short stature, precocious puberty, urogenital malformations and bone anomalies. BMC Medical Genomics 2019, 12, 5 .

AMA Style

Alice Monzani, Deepak Babu, Simona Mellone, Giulia Genoni, Antonella Fanelli, Flavia Prodam, Simonetta Bellone, Mara Giordano. Co-occurrence of genomic imbalances on Xp22.1 in the SHOX region and 15q25.2 in a girl with short stature, precocious puberty, urogenital malformations and bone anomalies. BMC Medical Genomics. 2019; 12 (1):5.

Chicago/Turabian Style

Alice Monzani; Deepak Babu; Simona Mellone; Giulia Genoni; Antonella Fanelli; Flavia Prodam; Simonetta Bellone; Mara Giordano. 2019. "Co-occurrence of genomic imbalances on Xp22.1 in the SHOX region and 15q25.2 in a girl with short stature, precocious puberty, urogenital malformations and bone anomalies." BMC Medical Genomics 12, no. 1: 5.

Book chapter
Published: 10 October 2018 in Neonatology
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Development is a continuous process that does not stop after birth but progresses along a continuum. The intestinal absorptive process is only partially mature before 26 weeks of gestation, and gastroenteropancreatic peptides and hormones are secreted in a basal rate and can be completely stimulated or inhibited after delivery, in particular with the nutrient contact. A growing knowledge about this complex interplay among nutrients, gut peptides, and the gut under development is an important tool in the clinical care of preterm newborns. The investigation of this system in fetal and neonatal life is still ongoing. This chapter will review the data about secretion of gut peptides (GLP-1, GLP-2, oxyntomodulin, GIP, PYY, ghrelin, obestatin, motilin, and cholecystokinin) in the neonatal period with respect to full-term or preterm birth, weight status, and feeding conditions. More detailed studies on this topic could offer the physiological basis for correct nutritional supports to preterm infants as well as therapies for the necrotizing enterocolitis.

ACS Style

Flavia Prodam; Simonetta Bellone; Roberta Ricotti; Alice Monzani; Giulia Genoni; Enza Giglione; Gianni Bona. Hormones and Gastrointestinal Function of Newborns. Neonatology 2018, 535 -555.

AMA Style

Flavia Prodam, Simonetta Bellone, Roberta Ricotti, Alice Monzani, Giulia Genoni, Enza Giglione, Gianni Bona. Hormones and Gastrointestinal Function of Newborns. Neonatology. 2018; ():535-555.

Chicago/Turabian Style

Flavia Prodam; Simonetta Bellone; Roberta Ricotti; Alice Monzani; Giulia Genoni; Enza Giglione; Gianni Bona. 2018. "Hormones and Gastrointestinal Function of Newborns." Neonatology , no. : 535-555.

Short report
Published: 27 September 2018 in Archives of Disease in Childhood - Fetal and Neonatal Edition
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BackgroundNeoTapAdvancedSupport (NeoTapAS) is a mobile application, based on a screen tapping method that calculates the heart rate (HR). We aimed to evaluate the accuracy of NeoTapAS in reliably determining HR from auscultation in a high-fidelity simulated newborn resuscitation scenario.MethodsPaediatric residents assessed HR by auscultation plus NeoTapAS in an asphyxiated term infant scenario and orally communicated the estimated HR. An external observer simultaneously documented the actual HR set in the manikin and the communicated HR.ResultsOne hundred and sixty HR measurements were recorded. The agreement between communicated and set HR was good (Cohen’s kappa 0.80, 95% CI 0.72 to 0.87; Bangdiwala’s weighted agreement strength statistic 0.93). Bland-Altman plot showed a mean difference between communicated and set HR values of 1 beats per minute (bpm) (95% agreement limits −9 to 11 bpm).ConclusionNeoTapAS showed a good accuracy in estimating HR and it could be an important resource in settings with limited availability of ECG monitor.

ACS Style

Marco Binotti; Francesco Cavallin; Pier Luigi Ingrassia; Nicolas J Pejovic; Alice Monzani; Giulia Genoni; Daniele Trevisanuto. Heart rate assessment using NeoTapAdvancedSupport: a simulation study. Archives of Disease in Childhood - Fetal and Neonatal Edition 2018, 104, F440 -2018.

AMA Style

Marco Binotti, Francesco Cavallin, Pier Luigi Ingrassia, Nicolas J Pejovic, Alice Monzani, Giulia Genoni, Daniele Trevisanuto. Heart rate assessment using NeoTapAdvancedSupport: a simulation study. Archives of Disease in Childhood - Fetal and Neonatal Edition. 2018; 104 (4):F440-2018.

Chicago/Turabian Style

Marco Binotti; Francesco Cavallin; Pier Luigi Ingrassia; Nicolas J Pejovic; Alice Monzani; Giulia Genoni; Daniele Trevisanuto. 2018. "Heart rate assessment using NeoTapAdvancedSupport: a simulation study." Archives of Disease in Childhood - Fetal and Neonatal Edition 104, no. 4: F440-2018.

Journal article
Published: 01 December 2017 in International Journal of Cardiology
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Childhood obesity is associated with cardiovascular abnormalities but little is known on the potential correlation between early cardiovascular and metabolic alterations.Aims of this study were 1) to evaluate early cardiovascular abnormalities in a large population of obese children and adolescents compared with a normal weight counterpart, 2) to investigate their potential association with insulin resistance (IR), serum uric acid (sUA) and metabolic syndrome (MetS).This was a single-center case-control study. Eighty obese (OB) subjects (6-16years) and 20 normal weight (NW) matched controls were consecutively recruited. In the whole population we performed an anthropometric and a cardiovascular assessment. OB patients also underwent an OGTT and biochemical evaluations.OB children showed greater left atrial (LA) and ventricular (LV) dimensions and mass and higher carotid artery intima-media thickness (CIMT), compared with NW controls. The BMI z-score, waist circumference, IR and sUA were positively related with LA and LV dimensions and mass. OB subjects with MetS (46.3%) showed greater LA diameter (p=0.001) and LV area (p=0.01) and volume (p=0.04) compared with OB children without MetS. LA diameter and LV dimensions and mass were significantly dependent on the number of criteria for MetS. Mets, sUA and IR were significant predictors of left heart dimensions and mass in obese children.Obesity and MetS are associated with abnormal cardiovascular response during childhood. Hyperuricemia can be an early marker of cardiovascular dysfunction and the routine determination of circulating levels of sUA should be implemented during risk stratification among pediatric age.

ACS Style

Giulia Genoni; Veronica Menegon; Gioel Gabrio Secco; Michela Sonzini; Massimiliano Martelli; Matteo Castagno; Roberta Ricotti; Alice Monzani; Michele Aronici; Elena Grossini; Carlo Di Mario; Gianni Bona; Simonetta Bellone; Flavia Prodam. Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. International Journal of Cardiology 2017, 249, 366 -371.

AMA Style

Giulia Genoni, Veronica Menegon, Gioel Gabrio Secco, Michela Sonzini, Massimiliano Martelli, Matteo Castagno, Roberta Ricotti, Alice Monzani, Michele Aronici, Elena Grossini, Carlo Di Mario, Gianni Bona, Simonetta Bellone, Flavia Prodam. Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity. International Journal of Cardiology. 2017; 249 ():366-371.

Chicago/Turabian Style

Giulia Genoni; Veronica Menegon; Gioel Gabrio Secco; Michela Sonzini; Massimiliano Martelli; Matteo Castagno; Roberta Ricotti; Alice Monzani; Michele Aronici; Elena Grossini; Carlo Di Mario; Gianni Bona; Simonetta Bellone; Flavia Prodam. 2017. "Insulin resistance, serum uric acid and metabolic syndrome are linked to cardiovascular dysfunction in pediatric obesity." International Journal of Cardiology 249, no. : 366-371.

Clinical trial
Published: 18 November 2017 in Pediatric Nephrology
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Impairment in orexigenic/anorexigenic hormone balance may be key in the pathogenesis of protein energy wasting in children with chronic kidney disease (CKD). Measurement of ghrelin and obestatin concentrations in children with CKD would help assess the potential contribution of these hormones to uremic protein energy wasting.

ACS Style

Alice Monzani; Michela Perrone; Flavia Prodam; Stefania Moia; Giulia Genoni; Sara Testa; Fabio Paglialonga; Anna Rapa; Gianni Bona; Giovanni Montini; Alberto Edefonti. Unacylated ghrelin and obestatin: promising biomarkers of protein energy wasting in children with chronic kidney disease. Pediatric Nephrology 2017, 33, 661 -672.

AMA Style

Alice Monzani, Michela Perrone, Flavia Prodam, Stefania Moia, Giulia Genoni, Sara Testa, Fabio Paglialonga, Anna Rapa, Gianni Bona, Giovanni Montini, Alberto Edefonti. Unacylated ghrelin and obestatin: promising biomarkers of protein energy wasting in children with chronic kidney disease. Pediatric Nephrology. 2017; 33 (4):661-672.

Chicago/Turabian Style

Alice Monzani; Michela Perrone; Flavia Prodam; Stefania Moia; Giulia Genoni; Sara Testa; Fabio Paglialonga; Anna Rapa; Gianni Bona; Giovanni Montini; Alberto Edefonti. 2017. "Unacylated ghrelin and obestatin: promising biomarkers of protein energy wasting in children with chronic kidney disease." Pediatric Nephrology 33, no. 4: 661-672.

Journal article
Published: 01 September 2017 in Minerva Endocrinologica
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The majority of patients idiopathic GHD proved to be transient. IGF-I levels alone do not discriminate subjects with persistent from those with transient GHD. Therefore, after the end of GH substitutive treatment, a re-evaluation of GH secretion is mandatory to verify the persistence of GHD in adulthood.

ACS Style

Cristina Meazza; Chiara Gertosio; Sara Pagani; Alba Pilotta; Carmine Tinelli; Fabio Buzi; Giovanni Farello; Giulia Genoni; Gianni Bona; Mauro Bozzola. Is retesting in growth hormone deficient children really useful? Minerva Endocrinologica 2017, 42, 325 -330.

AMA Style

Cristina Meazza, Chiara Gertosio, Sara Pagani, Alba Pilotta, Carmine Tinelli, Fabio Buzi, Giovanni Farello, Giulia Genoni, Gianni Bona, Mauro Bozzola. Is retesting in growth hormone deficient children really useful? Minerva Endocrinologica. 2017; 42 (4):325-330.

Chicago/Turabian Style

Cristina Meazza; Chiara Gertosio; Sara Pagani; Alba Pilotta; Carmine Tinelli; Fabio Buzi; Giovanni Farello; Giulia Genoni; Gianni Bona; Mauro Bozzola. 2017. "Is retesting in growth hormone deficient children really useful?" Minerva Endocrinologica 42, no. 4: 325-330.

Clinical trial
Published: 14 July 2017 in Acta Paediatrica
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This study evaluated whether an early aggressive nutrition (EAN) strategy could limit extrauterine growth restriction (EUGR) in a cohort of preterm infants. This prospective nonrandomised interventional study was carried out in the neonatal intensive care unit of an Italian hospital from January 2013 to December 2015. The prevalence of EUGR was assessed in 100 infants with a gestational age of ≤34 weeks, 50 after the introduction of an EAN regimen in October 2014 and 50 before. The prevalence of EUGR at discharge was significantly lower after the introduction of EAN than before for weight (34% vs. 66%), head circumference (22% vs. 42%) and length at discharge (20% vs. 48%). The Z-scores for all measurements were significantly higher after the introduction of EAN. In the EAN group, weight velocity was significantly higher and maximum weight loss and negative changes in the Z-scores from birth to discharge for weight were lower than in the pre-intervention controls. In extremely low birthweight subjects, the weight Z-score and weight velocity were significantly higher in the EAN group than the control group. The use of EAN at a very early age reduced EUGR and improved auxological outcomes in preterm infants.

ACS Style

Giulia Genoni; Marco Binotti; Alice Monzani; Elena Bernascone; Ilaria Stasi; Gianni Bona; Federica Ferrero. Nonrandomised interventional study showed that early aggressive nutrition was effective in reducing postnatal growth restriction in preterm infants. Acta Paediatrica 2017, 106, 1589 -1595.

AMA Style

Giulia Genoni, Marco Binotti, Alice Monzani, Elena Bernascone, Ilaria Stasi, Gianni Bona, Federica Ferrero. Nonrandomised interventional study showed that early aggressive nutrition was effective in reducing postnatal growth restriction in preterm infants. Acta Paediatrica. 2017; 106 (10):1589-1595.

Chicago/Turabian Style

Giulia Genoni; Marco Binotti; Alice Monzani; Elena Bernascone; Ilaria Stasi; Gianni Bona; Federica Ferrero. 2017. "Nonrandomised interventional study showed that early aggressive nutrition was effective in reducing postnatal growth restriction in preterm infants." Acta Paediatrica 106, no. 10: 1589-1595.

Case reports
Published: 25 October 2016 in PEDIATRICS
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Gianluca Cosi; Giulia Genoni; Alice Monzani; Barbara Pilan; Maria Lavrano; Federica Ferrero. Effective Neurally Adjusted Ventilatory Assist (NAVA) Ventilation in a Child With Jeune Syndrome. PEDIATRICS 2016, 138, e20160709 .

AMA Style

Gianluca Cosi, Giulia Genoni, Alice Monzani, Barbara Pilan, Maria Lavrano, Federica Ferrero. Effective Neurally Adjusted Ventilatory Assist (NAVA) Ventilation in a Child With Jeune Syndrome. PEDIATRICS. 2016; 138 (5):e20160709.

Chicago/Turabian Style

Gianluca Cosi; Giulia Genoni; Alice Monzani; Barbara Pilan; Maria Lavrano; Federica Ferrero. 2016. "Effective Neurally Adjusted Ventilatory Assist (NAVA) Ventilation in a Child With Jeune Syndrome." PEDIATRICS 138, no. 5: e20160709.

Journal article
Published: 29 June 2016 in Minerva pediatrica
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Sara Pagani; Gianpaolo De Filippo; Giulia Genoni; Domenico Rendina; Cristina Meazza; Elena Bozzola; Gianni Bona; Mauro Bozzola. Growth hormone receptor polymorphisms and growth hormone response to stimulation test: a pilot study. Minerva pediatrica 2016, 1 .

AMA Style

Sara Pagani, Gianpaolo De Filippo, Giulia Genoni, Domenico Rendina, Cristina Meazza, Elena Bozzola, Gianni Bona, Mauro Bozzola. Growth hormone receptor polymorphisms and growth hormone response to stimulation test: a pilot study. Minerva pediatrica. 2016; ():1.

Chicago/Turabian Style

Sara Pagani; Gianpaolo De Filippo; Giulia Genoni; Domenico Rendina; Cristina Meazza; Elena Bozzola; Gianni Bona; Mauro Bozzola. 2016. "Growth hormone receptor polymorphisms and growth hormone response to stimulation test: a pilot study." Minerva pediatrica , no. : 1.

Journal article
Published: 21 January 2015 in Minerva Pediatrica
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A Monzani; G Genoni; R Cassone; M Binotti; F Ferrero; G Bona. Hyperexcitability as the main sign of neonatal hypoxia. Minerva Pediatrica 2015, 67, 1 .

AMA Style

A Monzani, G Genoni, R Cassone, M Binotti, F Ferrero, G Bona. Hyperexcitability as the main sign of neonatal hypoxia. Minerva Pediatrica. 2015; 67 (3):1.

Chicago/Turabian Style

A Monzani; G Genoni; R Cassone; M Binotti; F Ferrero; G Bona. 2015. "Hyperexcitability as the main sign of neonatal hypoxia." Minerva Pediatrica 67, no. 3: 1.

Journal article
Published: 13 June 2014 in Journal of Endocrinological Investigation
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Vitamin D exerts pleiotropic effects and few studies are available in the Italian population. Aim of our study was to evaluate vitamin D status in children living in Northern Italy. We studied vitamin D levels in a population of 113 normal weight (NW) and 444 obese (OB) children, prepubertal and pubertal. We considered vitamin D levels >20 ng/ml as normal, but also measured percentage of children with vitamin D levels higher than a cutoff of 30 ng/ml. 68.2 % of NW children showed normal levels of vitamin D, while 31.8 % showed a clear vitamin D deficiency. Only 28.3 % showed vitamin D levels higher than 30 ng/ml. Obese children showed 55.6 % of subjects with normal levels of vitamin D and 44.4 % of subjects a status of vitamin D deficiency. Only the 18.9 % showed vitamin D levels higher than 30 ng/ml. Mean vitamin D levels in NW children (27.3 ± 1.2 ng/ml) were higher than in OB children (21.8 ± 0.6 ng/ml). No differences have been found between prepubertal and pubertal children in terms of vitamin D levels. Our paediatric population demonstrates a low percentage of vitamin D sufficiency. In particular, obese children show only 19 % of subjects with normal levels while almost half of this population shows a clear deficiency. Further studies are needed to support these results and to evaluate the possible metabolic consequences.

ACS Style

S. Bellone; S. Esposito; E. Giglione; G. Genoni; C. Fiorito; A. Petri; G. Bona; F. Prodam. Vitamin D levels in a paediatric population of normal weight and obese subjects. Journal of Endocrinological Investigation 2014, 37, 805 -809.

AMA Style

S. Bellone, S. Esposito, E. Giglione, G. Genoni, C. Fiorito, A. Petri, G. Bona, F. Prodam. Vitamin D levels in a paediatric population of normal weight and obese subjects. Journal of Endocrinological Investigation. 2014; 37 (9):805-809.

Chicago/Turabian Style

S. Bellone; S. Esposito; E. Giglione; G. Genoni; C. Fiorito; A. Petri; G. Bona; F. Prodam. 2014. "Vitamin D levels in a paediatric population of normal weight and obese subjects." Journal of Endocrinological Investigation 37, no. 9: 805-809.

Review
Published: 22 October 2013 in European Journal of Nuclear Medicine and Molecular Imaging
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The prevalence of obesity has exponentially risen worldwide. The etiology of obesity is multifactorial, and genetic inheritance and behavioral/environmental causes are considered the main etiological factors. Moreover, evidence that specific infections might promote the development of obesity has steadily accumulated. Only a few works investigate the impact of obesity on the immune response to infections and the risk of infections in the obese population. The aim of this paper was to review the available data regarding the various aspects of the association between obesity and infections and to highlight the possibility that infectious agents may have an etiological role in obesity, an idea known as “infectobesity”. Several microbes have been considered as possible promoter of obesity, but most of the data concern adenovirus-36 that exerts an adipogenic action mainly via a direct effect on adipose tissue leading to weight gain, at least in animal models. Obesity affects the immune response leading to an increased susceptibility to infections. Obese adults and children show an increased incidence of both nosocomial and community-acquired infections. Furthermore, obesity may alter the pharmacokinetics of antimicrobial drugs and impact on vaccine response. However, the various aspects of the association of obesity infections remain poorly studied, and a call to research is necessary to better investigate the problem. In conclusion, obesity impacts millions globally, and greater understanding of its etiology and its effects on immunity, infections, and prevention and management strategies is a key public health concern.

ACS Style

Giulia Genoni; Flavia Prodam; Agostina Marolda; Enza Giglione; Irene Demarchi; Simonetta Bellone; Gianni Bona. Obesity and infection: two sides of one coin. European Journal of Nuclear Medicine and Molecular Imaging 2013, 173, 25 -32.

AMA Style

Giulia Genoni, Flavia Prodam, Agostina Marolda, Enza Giglione, Irene Demarchi, Simonetta Bellone, Gianni Bona. Obesity and infection: two sides of one coin. European Journal of Nuclear Medicine and Molecular Imaging. 2013; 173 (1):25-32.

Chicago/Turabian Style

Giulia Genoni; Flavia Prodam; Agostina Marolda; Enza Giglione; Irene Demarchi; Simonetta Bellone; Gianni Bona. 2013. "Obesity and infection: two sides of one coin." European Journal of Nuclear Medicine and Molecular Imaging 173, no. 1: 25-32.