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(1) Background: During the global spread of COVID-19, Japan has been among the top countries to maintain a relatively low number of infections, despite implementing limited institutional interventions and its high population density. This study investigated how limited intervention policies have affected public health and economic conditions in the COVID-19 context and aimed to gain insight into the effective and sustainable measures against new infectious diseases in densely inhabited areas. (2) Methods: A system dynamics approach was employed. Qualitative causal loop analysis and stock and quantitative flow model analysis were performed, using a Tokyo Metropolitan area dataset. (3) Results: A causal loop analysis suggested that there were risks in prematurely terminating such interventions. Based on this result and the subsequent quantitative modeling, we found that the short-term effectiveness of a short-term pre-emptive stay-at-home request caused a resurgence in the number of positive cases, whereas an additional request provided a limited negative add-on effect for economic measures (e.g., number of electronic word-of-mouth communications and restaurant visits). (4) Conclusions: These findings suggest the superiority of a mild and continuous intervention as a long-term countermeasure under epidemic pressures when compared with strong intermittent interventions.
Makoto Niwa; Yasushi Hara; Yusuke Matsuo; Hodaka Narita; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. Superiority of Mild Interventions against COVID-19 on Public Health and Economic Measures. Journal of Personalized Medicine 2021, 11, 719 .
AMA StyleMakoto Niwa, Yasushi Hara, Yusuke Matsuo, Hodaka Narita, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama. Superiority of Mild Interventions against COVID-19 on Public Health and Economic Measures. Journal of Personalized Medicine. 2021; 11 (8):719.
Chicago/Turabian StyleMakoto Niwa; Yasushi Hara; Yusuke Matsuo; Hodaka Narita; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. 2021. "Superiority of Mild Interventions against COVID-19 on Public Health and Economic Measures." Journal of Personalized Medicine 11, no. 8: 719.
BACKGROUND A construction method has emerged in which a camera is installed around a construction machine, and the operator remotely controls the machine while synchronizing the vibration of the machine with the images seen from the operator's seat using virtual reality (VR) technology. Indices related to changes in heart rate and physical vibration, such as heart rate variability (HRV) and multiscale entropy (MSE), can then be measured in the operators. As these indices are quantitative measures of autonomic regulation in the cardiovascular system, they can provide a useful means of assessing operational stress. OBJECTIVE This study aimed to improve the efficiency of machine operation by evaluating the changes in the heart rate and body vibration of the machine operators, while considering the psychological load on the operators. METHODS Nine remote operators (18–48 years old) participated in the experiment, which involved 42 measurements. A construction machine was driven on a test course simulating a construction site, and three patterns of operation—riding operation of the machine, remote operation using monitor images, and VR operation combining monitor images and machine vibration—were compared. The heartbeat, body vibration, and driving time of the participants were measured using a sensing wear made of woven film-like conductive material and a 3-axis acceleration measurement device (WHS-2). We used HRV analysis in the time and frequency domains, MSE analysis as a measure of the complexity of heart rate changes, and the ISO 2631 vibration index. Multiple regression analysis was used to model the relationship between HRV low frequency (LF)/high frequency (HF), MSE, vibration index, and driving time of construction equipment. Efficient driving time was investigated with a focus on stress reduction. RESULTS Multiple comparisons using the Bonferroni test and Kruskal-Wallis test showed statistically significant differences (P=.05) in HRV-LF/HF, the vibration indices Aw and motion sickness dose value (MSDV), and driving time among the three operation patterns. The riding operation was found to reduce the driving time of the machine, but the operation stress was the highest in this case; operation by the monitor image was found to have the lowest operation stress but the longest operation time. Multiple regression analysis showed that the explanatory variables (LH/HF), R-R interval (RRI), and vibration index (MSDVz by vertical oscillation of 0.5–5 Hz) had a negative effect on driving time (adjusted R2=0.449). CONCLUSIONS A new method was developed to calculate the appropriate operating time by considering operational stress and suppressing the physical vibration within an acceptable range. By focusing on the relationship between psychological load and physical vibration, which has left unexplored in previous studies, the relationship of these variables with the driving time of construction machines was clarified.
Nobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Shinichi Kuroishi; Yasuhiro Miyazaki; Shigeo Kitahara; Shintaro Sengoku; Kota Kodama. Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint). 2021, 1 .
AMA StyleNobuki Hashiguchi, Jianfei Cao, Yeongjoo Lim, Shinichi Kuroishi, Yasuhiro Miyazaki, Shigeo Kitahara, Shintaro Sengoku, Kota Kodama. Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint). . 2021; ():1.
Chicago/Turabian StyleNobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Shinichi Kuroishi; Yasuhiro Miyazaki; Shigeo Kitahara; Shintaro Sengoku; Kota Kodama. 2021. "Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint)." , no. : 1.
Nobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Shinichi Kuroishi; Yasuhiro Miyazaki; Shigeo Kitahara; Shintaro Sengoku; Katsushi Matsubayashi; Kota Kodama. Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint). JMIR mHealth and uHealth 2021, 1 .
AMA StyleNobuki Hashiguchi, Jianfei Cao, Yeongjoo Lim, Shinichi Kuroishi, Yasuhiro Miyazaki, Shigeo Kitahara, Shintaro Sengoku, Katsushi Matsubayashi, Kota Kodama. Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint). JMIR mHealth and uHealth. 2021; ():1.
Chicago/Turabian StyleNobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Shinichi Kuroishi; Yasuhiro Miyazaki; Shigeo Kitahara; Shintaro Sengoku; Katsushi Matsubayashi; Kota Kodama. 2021. "Psychological Effects of Heart Rate and Physical Vibration on the Operation of Construction Machine: An Experimental Study (Preprint)." JMIR mHealth and uHealth , no. : 1.
BACKGROUND Smartphones have become an integral part of our lives with their unprecedented popularity and diversification of applications. The continuous upgrading of information technology has also enabled smartphones to display great potential in the field of healthcare. OBJECTIVE This study aimed to clarify the future research direction of mHealth by analyzing its research trends and latest research hotspots. METHODS This study collected mHealth-related literature published between 2000 and 2020 from the Web of Science database. Descriptive statistics of the literature were computed using Excel software. The publication trends of mHealth research were determined by analyzing the annual number of publications in the literature and annual number of publications categorized based on different countries. Finally, this study used the VOSviewer tool to construct visualization network maps of country/region collaborations and author keyword co-occurrences, and overlay visualization maps of the average publication year of author keywords to analyze the hotspots and research trends in mHealth research. RESULTS In this study, 12,593 mHealth-related research articles published between 2000 and 2020 were collected. The results showed an exponential growth trend in the number of annual publications in mHealth literature. The United States remained the leading contributor to the literature in this area (5,294/12,593, 42%), well ahead of other countries/regions. Other countries/regions also showed a clear trend of annual increases in the number of publications in mHealth literature. Regarding cooperation between countries, the four countries with the largest number of publications, the United States, the United Kingdom, Canada, and Australia, were found to cooperate more closely. The rest of the countries/regions showed a clear geographical pattern of cooperation. The keyword co-occurrence analysis of the top 100 authors formed five clusters, namely: development of mHealth medical technology and its application in various diseases, use of mHealth technology to improve basic public health and health policy, mHealth self-health testing and management in daily life, adolescent use of mHealth, and mHealth in mental health. The research trends revealed a gradual shift in mHealth research from health policy and improving public healthcare to the development and social application of mHealth technologies. CONCLUSIONS To the best of our knowledge, the most current bibliometric analysis dates back to 2016. However, the number of mHealth researches published between 2017 and 2020 exceeds the previous total. Therefore, the results of this study shed light on the latest research hotspots and research trends in mHealth research. These findings provide a useful overview of the development of the field; they may also serve as a valuable reference and provide guidance for other researchers in the field.
Jianfei Cao; Yeongjoo Lim; Shintaro Sengoku; Xitong Guo; Kota Kodama. A Paradigm Shift in Healthcare Innovation as Revealed by Research Trends in Mobile Health: A Bibliometric Analysis. (Preprint). 2021, 1 .
AMA StyleJianfei Cao, Yeongjoo Lim, Shintaro Sengoku, Xitong Guo, Kota Kodama. A Paradigm Shift in Healthcare Innovation as Revealed by Research Trends in Mobile Health: A Bibliometric Analysis. (Preprint). . 2021; ():1.
Chicago/Turabian StyleJianfei Cao; Yeongjoo Lim; Shintaro Sengoku; Xitong Guo; Kota Kodama. 2021. "A Paradigm Shift in Healthcare Innovation as Revealed by Research Trends in Mobile Health: A Bibliometric Analysis. (Preprint)." , no. : 1.
Jianfei Cao; Yeongjoo Lim; Shintaro Sengoku; Xitong Guo; Kota Kodama. Exploring the Shift in International Trends in Mobile Health Research: A Bibliometric Analysis from 2000 to 2020 (Preprint). JMIR mHealth and uHealth 2021, 1 .
AMA StyleJianfei Cao, Yeongjoo Lim, Shintaro Sengoku, Xitong Guo, Kota Kodama. Exploring the Shift in International Trends in Mobile Health Research: A Bibliometric Analysis from 2000 to 2020 (Preprint). JMIR mHealth and uHealth. 2021; ():1.
Chicago/Turabian StyleJianfei Cao; Yeongjoo Lim; Shintaro Sengoku; Xitong Guo; Kota Kodama. 2021. "Exploring the Shift in International Trends in Mobile Health Research: A Bibliometric Analysis from 2000 to 2020 (Preprint)." JMIR mHealth and uHealth , no. : 1.
We studied the overview of drug discovery and development to understand the recent trends and potential success factors of interorganizational collaboration by reviewing 1204 transactions performed until 2019 for 107 anticancer drugs approved by the US Food and Drug Administration (FDA) from 1999 to 2018. Immune checkpoint blockade was found to be a significantly active area in interorganizational transactions, especially the number of alliances, compared with other mechanisms of action of small molecules and biologics for cancer treatment. Furthermore, the analysis of pembrolizumab and nivolumab showed that the number of approved indications for these two drugs has been rapidly expanding since their first approval in 2014. Examination of the acquisitions and alliances regarding pembrolizumab and nivolumab showed that many combination partners were developed by US-based biotechnology or start-up companies, the majority of which were biologics. These findings suggest that immune checkpoint blockade is a paradigm for cancer treatment, resulting in huge product sales and continuous indication expansion. Additionally, interorganizational collaboration, especially trial collaboration, is a strategic approach for the development of immune checkpoint blockade agents. The translation of these empirical practices to new drug candidates is expected for the research and development of innovative drugs in the future.
Arisa Djurian; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. Dynamic Collaborations for the Development of Immune Checkpoint Blockade Agents. Journal of Personalized Medicine 2021, 11, 460 .
AMA StyleArisa Djurian, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama. Dynamic Collaborations for the Development of Immune Checkpoint Blockade Agents. Journal of Personalized Medicine. 2021; 11 (6):460.
Chicago/Turabian StyleArisa Djurian; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. 2021. "Dynamic Collaborations for the Development of Immune Checkpoint Blockade Agents." Journal of Personalized Medicine 11, no. 6: 460.
The purpose of this study is to investigate the effects of education for employees on learning outcomes and educational quality characteristics on organisational performance through analysis of the relationship between education quality characteristics, learning satisfaction, learning outcomes, and organisational performance. In this study, a research model based on IS-Success Model of Delone and McLean (2003) was established. A total of 320 questionnaires were distributed to small and medium-sized enterprises in Korea, among which a total of 258 questionnaires were analysed, and the following results were obtained. First, information quality and system quality had significant effects on learning satisfaction and learning outcomes, but service quality had a significant effect on only learning outcomes. In particular, it was ascertained that the educational design in the system quality aspect that has high job relatedness and applicability to work-site operations had a high level of influence. Second, learning satisfaction was found to have a significant effect on learning outcomes. Lastly, learning outcomes had a significant effect on job satisfaction, organisational commitment, and perceived financial performance. The results have significant implications for companies that hesitate to invest in education and training based on the belief that it equates to cost increase not to the increase in the organisational performance.
Jeongseon Hwang; Yeongjoo Lim. An effect of educational quality on learning outcomes and organizational performance: focused on Korean small and medium-sized enterprises (SMEs). Journal of Education and Work 2021, 34, 158 -169.
AMA StyleJeongseon Hwang, Yeongjoo Lim. An effect of educational quality on learning outcomes and organizational performance: focused on Korean small and medium-sized enterprises (SMEs). Journal of Education and Work. 2021; 34 (2):158-169.
Chicago/Turabian StyleJeongseon Hwang; Yeongjoo Lim. 2021. "An effect of educational quality on learning outcomes and organizational performance: focused on Korean small and medium-sized enterprises (SMEs)." Journal of Education and Work 34, no. 2: 158-169.
The increasing sophistication and complexity of construction technology have also increased workers’ physical risk and psychological stress. This study examined the relationships between health risks, work motivation, and productivity as perceived by construction workers. A hypothetical model of worker perceptions, and the psychological factors influencing these perceptions, was developed. A total of 324 construction workers at a Japanese construction company participated in the study and were divided into two groups: younger (45 years of age and below) and older adults (46 years of age and above). Data were collected using a questionnaire. The differences between the age groups were analyzed with regard to their perceptions of health risks, motivation, work skills, and productivity. Both younger and older workers were affected by intrinsic motivations and extrinsic motivations, but the effect of these motivations on work performance differed depending on age. Higher health risks are anticipated to affect the work motivation and productivity perceptions of older workers. The proposed model and findings of this study contribute to understanding worker motivations and have important implications for labor management of construction projects. By addressing construction workers’ intrinsic (e.g., interest) and extrinsic (e.g., reward) motivations, it is possible to sustainably improve project productivity.
Nobuki Hashiguchi; Shintaro Sengoku; Yasushi Kubota; Shigeo Kitahara; Yeongjoo Lim; Kota Kodama. Age-Dependent Influence of Intrinsic and Extrinsic Motivations on Construction Worker Performance. International Journal of Environmental Research and Public Health 2020, 18, 111 .
AMA StyleNobuki Hashiguchi, Shintaro Sengoku, Yasushi Kubota, Shigeo Kitahara, Yeongjoo Lim, Kota Kodama. Age-Dependent Influence of Intrinsic and Extrinsic Motivations on Construction Worker Performance. International Journal of Environmental Research and Public Health. 2020; 18 (1):111.
Chicago/Turabian StyleNobuki Hashiguchi; Shintaro Sengoku; Yasushi Kubota; Shigeo Kitahara; Yeongjoo Lim; Kota Kodama. 2020. "Age-Dependent Influence of Intrinsic and Extrinsic Motivations on Construction Worker Performance." International Journal of Environmental Research and Public Health 18, no. 1: 111.
An important agenda of pharmaceutical companies is the establishment of therapeutic area strategies, drug modality, and geographic strategies for research and development. It is worthwhile to understand the changes in therapeutic area, modality and internationalization of the top-selling pharmaceutical drugs over the past. Hence, the purposes of this study are to investigate changes in therapeutic area, modality and internationalization of the top-selling drugs and to identify their life cycle patterns. We compared the top-selling drugs between 2011 and 2017, and found that the percentages of nichebuster cancer drugs and home region-oriented drugs have increased whereas the proportions of traditional blockbuster cardiovascular drugs and global drugs have decreased. We compared product life cycle patterns via a Kruskal–Wallis test, and identified the features of product life cycle patterns per therapeutic area and modality. We performed a case study on drugs in the same class with the same pharmacological mechanism but found no differences across cases. Our results provide insights into therapeutic area strategies that consider life cycle patterns and geographic strategies that consider the competitive advantages of home region-oriented drugs. Finally, we presented new and simple models of life cycle patterns. This approach may help such enterprises establish and maintain sustainable growth.
Fumio Teramae; Tomohiro Makino; Shintaro Sengoku; Yeongjoo Lim; Takashi Natori; Kota Kodama. Research on Pharmaceutical Product Life Cycle Patterns for Sustainable Growth. Sustainability 2020, 12, 8938 .
AMA StyleFumio Teramae, Tomohiro Makino, Shintaro Sengoku, Yeongjoo Lim, Takashi Natori, Kota Kodama. Research on Pharmaceutical Product Life Cycle Patterns for Sustainable Growth. Sustainability. 2020; 12 (21):8938.
Chicago/Turabian StyleFumio Teramae; Tomohiro Makino; Shintaro Sengoku; Yeongjoo Lim; Takashi Natori; Kota Kodama. 2020. "Research on Pharmaceutical Product Life Cycle Patterns for Sustainable Growth." Sustainability 12, no. 21: 8938.
A key concept in the pharmaceutical industry is open innovation, in which pharmaceutical companies contribute to human health and adapt to a changing business environment by acquiring external knowledge. As successful drug discoveries and developments have become challenging, pharmaceutical companies must proactively pursue the open innovation of new drugs through various inter-firm partnerships to be more sustainable. This study aims to interpret the trend of inter-firm partnerships in the development of cancer drugs and to evaluate their effectiveness by examining inter-firm transactions related to cancer drugs approved by the US Food and Drug Administration (FDA). It is a novel approach to exercise this on each product instead of at the company level. The findings revealed that the number of inter-firm transactions in the oncology field has increased over the past 20 years. Furthermore, the annual number of transactions related to biologics has surpassed that of small molecules since 2015 and has been primarily driven by three PD-(L)1 inhibitors: Keytruda, Opdivo, and Tecentriq. Moreover, the average number of inter-firm transactions related to biologics is significantly higher than that of small molecules in total, in alliances, and in financing, suggesting that inter-firm transactions for biologic cancer drugs actively occur through various means. Additionally, a positive and significant correlation exists between the number of transactions and the average number of approved indications for biologics, but not for small molecules. These results suggest that the observed trend of active inter-firm transactions is key in increasing the probability of success in cancer drug research and development. This could provide a potential breakthrough in this industry for the successful development of innovative drug candidates to address unmet medical needs. Further study is necessary to confirm the applicability of this paradigm in broader drug discoveries and development.
Arisa Djurian; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. Trends of Business-to-Business Transactions to Develop Innovative Cancer Drugs. Sustainability 2020, 12, 5535 .
AMA StyleArisa Djurian, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama. Trends of Business-to-Business Transactions to Develop Innovative Cancer Drugs. Sustainability. 2020; 12 (14):5535.
Chicago/Turabian StyleArisa Djurian; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. 2020. "Trends of Business-to-Business Transactions to Develop Innovative Cancer Drugs." Sustainability 12, no. 14: 5535.
It is important for construction companies to sustain a productive workforce without sacrificing its health and safety. This study aims to develop a practical judgement method to estimate the workload risk of individual construction workers. Based on studies, we developed a workload model comprising a hygrothermal environment, behavioral information, and the physical characteristics of workers). The construction workers’ heart rate and physical activity were measured using the data collected from a wearable device equipped with a biosensor and an acceleration sensor. This study is the first report to use worker physical activity, age, and the wet bulb globe temperature (WBGT) to determine a worker’s physical workload. The accuracy of this health risk judgment result was 89.2%, indicating that it is possible to easily judge the health risk of workers even in an environment where it is difficult to measure the subject in advance. The proposed model and its findings can aid in monitoring the health impacts of working conditions during construction activities, and thereby contribute toward determining workers’ health damage. However, the sampled construction workers are 12 workers, further studies in other working conditions are required to accumulate more evidence and assure the accuracy of the models.
Nobuki Hashiguchi; Kota Kodama; Yeongjoo Lim; Chang Che; Shinichi Kuroishi; Yasuhiro Miyazaki; Taizo Kobayashi; Shigeo Kitahara; Kazuyoshi Tateyama. Practical Judgment of Workload Based on Physical Activity, Work Conditions, and Worker’s Age in Construction Site. Sensors 2020, 20, 3786 .
AMA StyleNobuki Hashiguchi, Kota Kodama, Yeongjoo Lim, Chang Che, Shinichi Kuroishi, Yasuhiro Miyazaki, Taizo Kobayashi, Shigeo Kitahara, Kazuyoshi Tateyama. Practical Judgment of Workload Based on Physical Activity, Work Conditions, and Worker’s Age in Construction Site. Sensors. 2020; 20 (13):3786.
Chicago/Turabian StyleNobuki Hashiguchi; Kota Kodama; Yeongjoo Lim; Chang Che; Shinichi Kuroishi; Yasuhiro Miyazaki; Taizo Kobayashi; Shigeo Kitahara; Kazuyoshi Tateyama. 2020. "Practical Judgment of Workload Based on Physical Activity, Work Conditions, and Worker’s Age in Construction Site." Sensors 20, no. 13: 3786.
Research and development (R&D) productivity is continuously declining, and it is said that the conventional model of pharmaceutical business is becoming obsolete. Many research studies on R&D productivity focus on inputs (e.g., strategic transactions to absorb external innovation, R&D expenditures), outputs (e.g., approvals of a new drug), and outcomes (e.g., total sales, incomes). However, few prior studies address the relationship among these three components simultaneously. Therefore, we comprehensively analyzed factors affecting R&D productivity by statistically examining a sample of 30 large multinational companies. Our results show that strategic transactions do not increase the number of approved drugs and negatively affect growth in terms of total sales. Additionally, our results show that a home-region-oriented international strategy positively affects total sales, thus indicating that responsiveness to local medical needs is important for sustainable growth. This paper contributes to the body of research on R&D productivity in the pharmaceutical industry.
Fumio Teramae; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. Impact of Research and Development Strategy on Sustainable Growth in Multinational Pharmaceutical Companies. Sustainability 2020, 12, 5358 .
AMA StyleFumio Teramae, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama. Impact of Research and Development Strategy on Sustainable Growth in Multinational Pharmaceutical Companies. Sustainability. 2020; 12 (13):5358.
Chicago/Turabian StyleFumio Teramae; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. 2020. "Impact of Research and Development Strategy on Sustainable Growth in Multinational Pharmaceutical Companies." Sustainability 12, no. 13: 5358.
The construction industry is a work environment that poses many dangers to workers, with many hidden factors that affect work awareness. It is important for construction companies to ensure a balance between productivity and safety in the work environment. The purpose of this study was to identify relationships between the feeling of safety in the work environment, proactive work behavior, job satisfaction, work skills, team performance, and health risk indicators, such as heart rate, among construction workers of different ages. Based on previous research, we examined the hypothetical perception model. We then administered a questionnaire survey to construction workers (N = 357) employed at a Japanese construction company. Using structural equation modeling (SEM), we investigated the impact of health risk indicators on worker perceptions among young and older workers. The results showed that workers’ heart rate and body mass index (BMI) had a negative effect on the feeling of safety and proactive work behavior among older workers, but showed no significant relationship among young workers. However, regardless of workers’ age, it was clear that the feeling of safety affects job satisfaction, and that work skills and proactive work behaviors affect perceptions regarding team performance.
Nobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Yasushi Kubota; Shigeo Kitahara; Shuichi Ishida; Kota Kodama. The Effects of Psychological Factors on Perceptions of Productivity in Construction Sites in Japan by Worker Age. International Journal of Environmental Research and Public Health 2020, 17, 3517 .
AMA StyleNobuki Hashiguchi, Jianfei Cao, Yeongjoo Lim, Yasushi Kubota, Shigeo Kitahara, Shuichi Ishida, Kota Kodama. The Effects of Psychological Factors on Perceptions of Productivity in Construction Sites in Japan by Worker Age. International Journal of Environmental Research and Public Health. 2020; 17 (10):3517.
Chicago/Turabian StyleNobuki Hashiguchi; Jianfei Cao; Yeongjoo Lim; Yasushi Kubota; Shigeo Kitahara; Shuichi Ishida; Kota Kodama. 2020. "The Effects of Psychological Factors on Perceptions of Productivity in Construction Sites in Japan by Worker Age." International Journal of Environmental Research and Public Health 17, no. 10: 3517.
Genetically edited food utilizes new techniques that may decrease all of the risks associated with genetically modified food, or “GMO” food. Safety and labeling regulations for genetically edited food are still new, and it is challenging for the consumer to differentiate it from conventional food. Although genetically edited food has the potential for reducing the risks associated with the gene introduction process, consumer perceptions toward it are still unclear. The research has compared the regulations governing GMO food and genetically edited food in Japan, Europe, and the United States. We found that the genetically edited food regulations in Japan are the most science-based, in the meaning that genetically edited food products are allowed to be sold without any safety evaluation. Based on the difference among regions, we further studied the potential acceptance level for such products among Japanese consumers, where regulation seemed science-based as policy. To understand the factors that may affect the adoption of genetically edited food among youth in Japan, we utilized the structural equation modeling (SEM) method with 180 surveys of Japanese university students to measure six factors: Knowledge, Attitude Towards Technology, Perceived Benefits, Perceived Risks, Trust, and Willingness to Purchase. The survey was conducted twice with an intervention in the middle to measure the effect of science communication, and we found significant differences when comparing the two datasets. The results of this survey indicate the importance of increasing knowledge and the positive role of science communication in increasing the adoption and trust of biotechnology products, such as genetically edited food.
Mohamed Farid; Jianfei Cao; Yeongjoo Lim; Teruyo Arato; Kota Kodama. Exploring Factors Affecting the Acceptance of Genetically Edited Food Among Youth in Japan. International Journal of Environmental Research and Public Health 2020, 17, 2935 .
AMA StyleMohamed Farid, Jianfei Cao, Yeongjoo Lim, Teruyo Arato, Kota Kodama. Exploring Factors Affecting the Acceptance of Genetically Edited Food Among Youth in Japan. International Journal of Environmental Research and Public Health. 2020; 17 (8):2935.
Chicago/Turabian StyleMohamed Farid; Jianfei Cao; Yeongjoo Lim; Teruyo Arato; Kota Kodama. 2020. "Exploring Factors Affecting the Acceptance of Genetically Edited Food Among Youth in Japan." International Journal of Environmental Research and Public Health 17, no. 8: 2935.
Although it is generally agreed that the pharmaceutical industry is in a state of rapid internationalization, there is no clear comprehensive explanation of the current state and effectiveness of an international strategy. There are many studies about internationalization but they neither focus on the pharmaceutical industry nor evaluate the effectiveness of an international strategy with a control. Therefore, we investigate the current state of internationalization with a sample of the 30 multinational pharmaceutical companies, as well as the effectiveness of an international strategy by comparing two international strategies. In this study, we define an international strategy as a strategy that controls the geographic distribution of sales across regions to maximize total sales. The results show that 33% of the companies are still home-region-oriented, and we did not find any evidence of the effectiveness of an international strategy that pursues a balanced geographic distribution across regions in terms of total sales and adjusted total sales. The results provide the practical implication that pharmaceutical companies should weigh up the specific markets to secure higher sales through the advantage of adapting to customers’ needs. This paper contributes to the research on sustainable growth by empirically providing results of comparisons of different international strategies in the pharmaceutical industry.
Fumio Teramae; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. International Strategy for Sustainable Growth in Multinational Pharmaceutical Companies. Sustainability 2020, 12, 867 .
AMA StyleFumio Teramae, Tomohiro Makino, Yeongjoo Lim, Shintaro Sengoku, Kota Kodama. International Strategy for Sustainable Growth in Multinational Pharmaceutical Companies. Sustainability. 2020; 12 (3):867.
Chicago/Turabian StyleFumio Teramae; Tomohiro Makino; Yeongjoo Lim; Shintaro Sengoku; Kota Kodama. 2020. "International Strategy for Sustainable Growth in Multinational Pharmaceutical Companies." Sustainability 12, no. 3: 867.
Although external collaboration capability influences the development of personalized medicine, key transactions in the pharmaceutical industry have not been addressed. To explore specific trends in interorganizational transactions and key players, we longitudinally surveyed strategic transactions, comparing them with other advanced medical developments, such as antibody therapy, as controls. We found that the financing deals of start-ups have surged over the past decade, accelerating intellectual property (IP) creation. Our correlation and regression analyses identified determinants of financing deals among alliance deals, acquisition deals, patents, research and development (R&D) licenses, market licenses, and scientific papers. They showed that patents positively correlated with transactions, and that the number of R&D licenses significantly predicted financing deals. This indicates, for the first time, that start-ups and investors lead progress in personalized medicine.
Tomohiro Makino; Yeongjoo Lim; Kota Kodama. Strategic R&D transactions in personalized drug development. Drug Discovery Today 2018, 23, 1334 -1339.
AMA StyleTomohiro Makino, Yeongjoo Lim, Kota Kodama. Strategic R&D transactions in personalized drug development. Drug Discovery Today. 2018; 23 (7):1334-1339.
Chicago/Turabian StyleTomohiro Makino; Yeongjoo Lim; Kota Kodama. 2018. "Strategic R&D transactions in personalized drug development." Drug Discovery Today 23, no. 7: 1334-1339.