Pure amelanotic primary melanoma of the skin is rare, with the largest series suggesting an incidence of less than 2% of melanomas (although this figure is inflated because amelanotic metastases were included in the study).¹ Because evidence of melanin is usually found in amelanotic melanoma histopathologically,² the difficulty in diagnosing these lesions lies with the clinician and not the pathologist, and a precise clinical definition of melanoma lacking significant pigment would be most useful. Furthermore, since dermoscopic evaluation allows the visualization of pigment not seen with the naked eye, a dermoscopic definition of lesions lacking significant pigment would be most useful and is presented in our study.