Hierarchical three-dimensional (3D) porous nanonetworks of nickel–cobalt layered double hydroxide (Ni–Co LDH) nanosheets (NSs) are grown and decorated on flexible conductive textile substrate (CTs) via a simple two-electrode system based electrochemical deposition (ED) method. By applying a proper external cathodic voltage of −1.2 V for 15 min, the Ni–Co LDH NSs are densely deposited over the entire surface of the CTs with good adhesion. The flexible Ni–Co LDH NSs on CTs (Ni–Co LDH NSs/CTs) architecture with high porosity facilitates enhanced electrochemical performance in 1 M KOH electrolyte solution. The effect of growth concentration and external cathodic voltage on the electrochemical properties of Ni–Co LDH NSs/CTs is also investigated. The Ni10Co5 LDH NSs/CTs electrode exhibits a high specific capacitance of 2105 F g−1 at a current density of 2 A g−1 as well as an excellent cyclic stability as a pseudocapacitive electrode due to the advantageous properties of 3D interconnected porous frameworks of Ni10Co5 LDH NSs/CTs. This facile fabrication of bimetallic hydroxide nanostructures on CTs can provide a promising electrode for low-cost energy storage device applications.
Breast cancer (BC) is the second most fatal disease and is the prime cause of cancer allied female deaths. BC is caused by aberrant tumor suppressor genes and oncogenes regulated by transcription factors (TFs) like NF-κB. NF-κB is a pro-inflammatory TF that crucially alters the expressions of various genes associated with inflammation, cell progression, metastasis, and apoptosis and modulates a network of genes that underlie tumorigenesis. Herein, we focus on NF-κB signaling pathways, its regulators, and the rationale for targeting NF-κB. This review also includes TFs that maintain NF-κB crosstalk and their roles in promoting angiogenesis and metastasis. In addition, we discuss the importance of combination therapies, resistance to treatment, and potential novel therapeutic strategies including nanomedicine that targets NF-κB.
18 June 2012 in Physical Chemistry Chemical Physics
Trivalent rare-earth (RE) ions (Eu3+, Tb3+ and Sm3+) activated multicolor emitting SrY2O4 phosphors were synthesized by a sol–gel process. The structural and morphological studies were performed by the measurements of X-ray diffraction profiles and scanning electron microscope (SEM) images. The pure phase of SrY2O4 appeared after annealing at 1300 °C and the doping of RE ions did not show any effect on the structural properties. From the SEM images, the closely packed particles were observed due to the roughness of each particle tip. The photoluminescence (PL) analysis of individual RE ions activated SrY2O4 phosphors exhibits excellent emission properties in their respective regions. The Eu3+ co-activated SrY2O4:Tb3+ phosphor creates different emissions by controlling the energy transfer from Tb3+ to Eu3+ ions. Based on the excitation wavelengths, multiple (green, orange and white) emissions were obtained by Sm3+ ions co-activated with SrY2O4:Tb3+ phosphors. The decay measurements were carried out for analyzing the energy transfer efficiency and the possible ways of energy transfer from donor to acceptor. The cathodoluminescence properties of these phosphors show similar behavior as PL properties except the energy transfer process. The obtained results indicated that the energy transfer process was quite opposite to the PL properties. The calculated CIE chromaticity coordinates of RE ions activated SrY2O4 phosphors confirmed the red, green, orange and white emissions.
Although much progress has been made in treating cancers, cancer death rates in and around the United States are still high. Current treatments are either ineffective against some cancers or detrimental to patients, which decreases their quality of life. The use of nanotechnology in cancer therapy can potentially increase patient survival, reduce side effects, and reduce mortality rates because nanoparticles (NPs) have the potential to target only tumors and bypass healthy cells. NPs possess many features, including size, shape, charge, and composition, which allow them to carry chemotherapeutics to cancer cells. NPs can also be used in radiotherapy as radiosensitizers and in imaging as contrast agents. Many studies have performed in vitro and/or in vivo experiments on these particles in human and animal cell lines. This review discusses recent studies on different NPs and their potential use in cancer therapy.