Introduction. Primary central nervous system lymphoma is an uncommon form of extranodal non-Hodgkin’s lymphoma, with increasing incidence, a relatively aggressive course and a poor 5-year survival. Because of its localization, the therapeutic compounds used in this disease must be able to pass through the blood-brain barrier. Chemotherapy regimens based on high-dose methotrexate are currently the standard of care for all patients who can tolerate such drugs. Autologous stem cell transplantation is indicated for malignant lymphomas in the relapsed/refractory setting. Methods. Three patients, with a median age of 60 years, range 53–64, were diagnosed with primary CNS lymphoma, and treated with ibrutinib monotherapy in the Department of Hematology, Ion Chiricuta Clinical Cancer Center, Cluj-Napoca, Romania, between September 2018 and November 2020 All the patients were relapsed–refractory following high-dose methotrexate chemotherapy. We present our experience using ibrutinib monotherapy-based treatment as a bridge-to-transplant option on a single-center case series and a review of the literature in this field. Results. Two of the patients were given ibrutinib as a second line therapy, both achieving complete remission and being eligible for an autologous stem cell transplantation. The third patient achieved a short remission using six cycles of systemic chemotherapy, but was started on ibrutinib monotherapy, with limited results. Conclusion. Our data is limited, and these results should be confirmed by multicentric clinical trials and should be regarded as a single-center case series, with all its limitations. Still, it brings forward a new therapeutic option for this rare subtype of malignant lymphomas, which if left untreated has a dismal prognosis.

Burnout syndrome has an increasing incidence among intensive therapists because of high expectations and stress which leads to physical, mental and emotional exhaustion. Our aim was to examine the causes and severity of burnout in intensive care units. Maslach Burnout Inventory questionnaires were distributed among intensive care workers of an university and a town hospital. Socio-demographic data were also collected. The questionnaires were completed by 67 professionals, 28 doctors, 39 nurses. 43.4% suffered serious burnout, 23.52% high level of depersonalization, only 19.11% were satisfied with their accomplishments. Females showed higher incidence of burnout, especially those with chronic diseases (OR=3.33). According to our data, burnout was not related to family status and working hours, however there was significant correlation between satisfaction and weekly relaxation time (p = 0.0115). Burnout syndrome is spreading among intensive care employees, therefore its prevention should be a priority.