This study examined the relationship between the adoption of bio-fortified provitamin- A cassava varieties and farming households’ health outcomes using cross sectional data obtained from 318 cassava farmers in southeast Nigeria. The data was analysed using binary logistic regression, propensity score matching of treatment effects and percentages. The study found that number of children under five, household size, education of head of household, extension service, ownership of television, radio, mobile phone and tricycle, membership of cooperative societies, and access to credit were the significant predictors of adoption of pro-vitamin-A bio-fortified cassava varieties in the States. The study also found that the main constraints militating against adoption of pro-vitamin-A bio-fortified cassava include decaying of roots immediately after maturation,high cost of cassava stem, and high moisture content. The estimate of the effect of the adoption of bio-fortified pro-vitamin-A cassava varieties onincidence of vitamin-A deficiency related diseases was significant with an average treatment effect on the adopters of -0.463. The adoption of bio- fortified pro-vitamin-A cassava varieties has substantial effect on the reduction of vitamin-A deficiency related health outcomes. There is need for wider awareness and dissemination of the varieties among cassava farmers, while interventions should target the promotion of both production and consumption of such cassava varieties. Key words: adoption of bio-fortified cassava varieties; vitamin A deficiency related diseases