Prof. Franz E. Weber
University of Zurich, Switzerland, Center for Dentistry, Oral Biotechnology & Bioengineering
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Academic Career Length
45Years (1982-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications9 April 2003 in Proceedings of the National Academy of Sciences
Journal Article
MLM. P. Lutolf
M. P. Lutolf
JLJ. L. Lauer-Fields
J. L. Lauer-Fields
HSH. G. Schmoekel
H. G. Schmoekel
AMA. T. Metters
A. T. Metters
Franz E. WeberJHJ. A. Hubbell
J. A. Hubbell +1
Synthetic hydrogels have been molecularly engineered to mimic the invasive characteristics of native provisional extracellular matrices: a combination of integrin-binding sites and substrates for matrix metalloproteinases (MMP) was required to render the networks degradable and invasive by cells via cell-secreted MMPs. Degradation of gels was engineered starting from a characterization of the degradation kinetics (kcatandKm) of synthetic MMP substrates in the soluble form and after crosslinking into a 3D hydrogel network. Primary human fibroblasts were demonstrated to proteolytically invade these networks, a process that depended on MMP substrate activity, adhesion ligand concentration, and network crosslinking density. Gels used to deliver recombinant human bone morphogenetic protein-2 to the site of critical defects in rat cranium were completely infiltrated by cells and remodeled into bony tissue within 4 wk at a dose of 5 μg per defect. Bone regeneration was also shown to depend on the proteolytic sensitivity of the matrices. These hydrogels may be useful in tissue engineering and cell biology as alternatives for naturally occurring extracellular matrix-derived materials such as fibrin or collagen.
21 April 2003 in Nature Biotechnology
Journal Article
MLMatthias P. Lutolf
Matthias P. Lutolf
Franz E. WeberHSHugo G. Schmoekel
Hugo G. Schmoekel
JSJason C. Schense
Jason C. Schense
TKThomas Kohler
Thomas Kohler
JHJeffrey A. Hubbell
Jeffrey A. Hubbell +1
1 January 2011 in Biophysical Journal
Journal Article
MEMartin Ehrbar
Martin EhrbarASA. Sala
A. Sala
PLP. Lienemann
P. LienemannARA. Ranga
A. Ranga
KMK. Mosiewicz
K. Mosiewicz
MLMatthias Lutolf
Matthias Lutolf +3
21 September 2007 in Biomacromolecules
Journal Article
MEMartin Ehrbar
Martin EhrbarSRSimone C. Rizzi
Simone C. Rizzi
RSRonald G. Schoenmakers
Ronald G. Schoenmakers
BMBlanca San Miguel
Blanca San Miguel
JHJeffrey A. Hubbell
Jeffrey A. HubbellMLMatthias P. Lutolf
Matthias P. Lutolf
+1
9 September 2003 in Clinical Oral Implants Research
Journal Article
RJRonald E. Jung
Ronald E. JungRGRoland Glauser
Roland Glauser
PSPeter Schärer
Peter Schärer
CHChristoph H. F. Hämmerle
Christoph H. F. Hämmerle
HSHermann F. Sailer
Hermann F. Sailer
Franz E. Weber1 September 2007 in Biomaterials
Journal Article
MEMartin Ehrbar
Martin EhrbarSRSimone C. Rizzi
Simone C. Rizzi
RHRuslan Hlushchuk
Ruslan Hlushchuk
Valentin DjonovAZAndreas H. Zisch
Andreas H. Zisch
MLMatthias P. Lutolf
Matthias P. Lutolf
+2
About Me
Franz Weber graduated from the University Konstanz (Germany) with a PhD in Biology/Muscle Biochemistry. He completed a 3-year postdoctoral training on muscle cell biology at Cornell University Medical College in New York City and served as a lecturer in the Department of Cell Biology and Anatomy. He spent the following two years at Biochemistry of the ETH Zurich (École polytechnique fédérale) working on the lipid uptake from the small intestine. In 1995, he joined the Department of Cranio-Maxillofacial and Oral Surgery at the University Hospital Zurich and the Dental School of the University Zurich. Beside his obligations at the University of Zurich, he became Director of the European Technical Centre of Inion Ltd in Cambridge (UK) in 2005 and occupied this position until 2009. His main areas of interest are osteoconduction, scaffold design, bone growth, and pulp regeneration. His research encompasses additive manufacturing, bone substitutes, osteoconduction, bone morphogenetic proteins, delivery systems, epigenetics, and in vitro bone tissue engineering. Franz E. Weber has authored 129 peer-reviewed research articles published in international journals amounting to more than 5815 citations, 16 patents, several review articles, and an h-index of 34. He is member of TERMIS (Tissue Engineering international & Regenerative Medicine Society), IADR (International Association for Dental Research), DKG (German Ceramic Society), and ACerS (The American Ceramic Society).