Raymond Schinazi

Prof. Raymond Schinazi

orcid

Research Focus & Metrics

Academic Career Length

35Years (1992-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 August 2014 in Chemical Reviews
Verified
Journal Article
Open access
UPUgo Pradere
Ugo Pradere
EGEthel C. Garnier-Amblard
Ethel C. Garnier-Amblard
SCSteven J. Coats
Steven J. Coats
FAFranck Amblard
Franck Amblard
RSRaymond Schinazi
Raymond Schinazi

23 November 2016 in Chemical Reviews
Verified
Journal Article
Closed access
JSJadd Shelton
Jadd Shelton
XLXiao Lu
Xiao Lu
JHJoseph A. Hollenbaugh
Joseph A. Hollenbaugh
JCJong Hyun Cho
Jong Hyun Cho
FAFranck Amblard
Franck Amblard
RSRaymond Schinazi
Raymond Schinazi

1 March 2001 in Hepatology
Verified
Journal Article
Open access
PDF file
LSLieven J. Stuyver
Lieven J. Stuyver
SLStephen A. Locarnini
Stephen A. Locarnini
ALAnna Lok
Anna Lok
DRDouglas D. Richman
Douglas D. Richman
WCWilliam F. Carman
William F. Carman
RSRaymond Schinazi
Raymond Schinazi
There is currently no universally accepted numbering convention for the antiviral drug‐related resistance mutations in the reverse transcriptase (rt) domain of the human hepatitis B virus (HBV) polymerase. The published inconsistencies have resulted from different HBV genotypes. A standardized numbering system for HBV polymerase is proposed. The new system is based on functional observations of HBV surface gene proteins (preS1, preS2, and HBsAg) and on the current convention used for human immunodeficiency virus type 1 (HIV‐1) polymerase proteins (protease, rt, and integrase), in which the amino acid numbering restarts at the first codon position of each domain. The HBV polymerase protein can be divided into 4 domains (terminal protein, spacer, rt, ribonuclease H) and each of these can be numbered separately. In this proposal, the HBV rt domain starts with the highly conserved EDWGPCDEHG motif, contains 344 amino acids, and the lamivudine‐related resistance mutations are found at amino acid rtL180M (previously amino acid 528, 526, 515, or 525) and rtM204V/I (previously 552, 550, 539, or 549). The new consensus rt domain numbering system is genotype independent and allows investigators to number any previously and newly discovered antiviral‐related amino acid change in a standardized manner.

23 December 2013 in Liver International
Verified
Journal Article
Open access
PDF file
RSRaymond Schinazi
Raymond Schinazi
PHPhilippe Halfon
Philippe Halfon
PMPatrick Marcellin
Patrick Marcellin
TATarik Asselah
Tarik Asselah
For HCV infection, there have been major advancements during last several years with large numbers of ongoing trials with various direct‐acting antivirals (DAA) showing high potency, favourable tolerability profile, higher barrier to resistance, shortened treatment duration, all oral regimen, pan‐genotypic, fewer drug interactions and reduced pill burden. By 2014, several DAAs are anticipated to complete successful phase III trials and will be commercially available. Initially, a wave of IFN‐based regimen (sofosbuvir, faldaprevir and simeprevir) will be available for treatment of HCV genotype 1. In the near future, combination of antiviral agents with additive potency that lack cross‐resistance with good safety profile will likely be the new recommended regimens, making HCV, the first chronic viral infection to be eradicated worldwide with a finite duration of combination DAA therapy without IFN or ribavirin. The aim of this review was to summarize the results obtained from recent DAA combination studies without IFN.

1 February 2015 in Virology
Verified
Journal Article
Closed access
EKEdward M. Kennedy
Edward M. Kennedy
LBLeda C. Bassit
Leda C. Bassit
HMHenrik Mueller
Henrik Mueller
AKAnand V.R. Kornepati
Anand V.R. Kornepati
HBHal P. Bogerd
Hal P. Bogerd
BCBryan Cullen
Bryan Cullen

1 January 2021 in Cell
Verified
Journal Article
Closed access
THTimothy N. Hoang
Timothy N. Hoang
MPMaria Pino
Maria Pino
ABArun K. Boddapati
Arun K. Boddapati
EVElise G. Viox
Elise G. Viox
CSCarly E. Starke
Carly E. Starke
MPMirko Paiardini
Mirko Paiardini