Prof. Graziano Pinna is a professor in the Department of Psychiatry at the University of Illinois at Chicago (UIC). He earned his undergraduate and doctoral degrees at the University of Cagliari (Italy), followed by a PhD in neuroendocrinology at the Free University of Berlin (Germany). He was subsequently appointed assistant professor at UIC, where he established a translational research program focused on stress-induced neuropsychiatric disorders and their comorbidities. Prof. Pinna's work integrates preclinical and clinical research to investigate the neurobiological underpinnings of conditions such as posttraumatic stress disorder (PTSD), alcohol use disorder (AUD), and mood disorders-particularly those that disproportionately affect women, including premenstrual syndrome (PMS), premenstrual dysphoric disorder (PMDD), postpartum depression (PPD), major depression, and anxiety. His research employs metabolomics and molecular biology tools to study the GABAergic neurosteroid and endocannabinoid systems in both animal models and clinical populations. A major focus of his work is the impact of stress on the biosynthesis of neurosteroids like allopregnanolone and their congeners and the interplay between neurosteroid signaling and the endocannabinoid system with the aim to suggest novel therapeutic targets through a biomarker-driven precision medicine approach.