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Integrated earthquake simulation (IES) is a seamless simulation of analyzing all processes of earthquake hazard and disaster. There are two difficulties in carrying out IES, namely, the requirement of large-scale computation and the requirement of numerous analysis models for structures in an urban area, and they are solved by taking advantage of high performance computing (HPC) and by developing a system of automated model construction. HPC is a key element in developing IES, as it needs to analyze wave propagation and amplification processes in an underground structure; a model of high fidelity for the underground structure exceeds a degree-of-freedom larger than 100 billion. Examples of IES for Tokyo Metropolis are presented; the numerical computation is made by using K computer, the supercomputer of Japan. The estimation of earthquake hazard and disaster for a given earthquake scenario is made by the ground motion simulation and the urban area seismic response simulation, respectively, for the target area of 10,000 m × 10,000 m.